Experimental Pig Model
Mostrando 25-36 de 95 artigos, teses e dissertações.
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25. Standardization of an isolated pig heart preparation with parabiotic circulation: methodological considerations
In the present study we standardized an experimental model of parabiotic circulation of isolated pig heart. The isolated heart was perfused with arterial blood from a second animal as support and submitted to regional ischemia for 30 min, followed by total ischemia for 90 min and reperfusion for 90 min. Parameters for measurement of ventricular performance u
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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26. Estudo farmacolÃgico da ternatina, um flavonÃide isolado de Egletes viscosa, LESS / FarmacolÃgico study of the ternatina, an isolated flavonÃide of Egletes viscose, LESS
Ternatin (5, 4â-dihydroxy-3, 7, 8, 3â-tetrametoxy-flavone), a flavonoid which was extracted and purified from Egletes viscosa, Less. (Compositae), was screened for various pharmacological effects in experimental animals. The compound (15 and 30 mg/kg, i.p.) demonstrated a dose-related significant anti- inflammatory effect in the carrageenan-induced rat hin
Publicado em: 1991
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27. Estudo conformacional de proteínas por espectroscopia Raman laser e de absorção no infravermelho: toxina γ de tityus serrulatus e fosfolipases A2 de crotalus durissus terrificus e de pâncreas de porco e seu zimogênio / Conformational study of proteins by Raman laser and infrared absorption spectroscopies: gamma-toxin from Tityus serrulatus and phospholipases A2 from Crotalus durissus terrificus and from pig pancreas and its zymogen
Raman and infrared spectroscopies were used to investigate conformational features of some proteins of biological interest, in what concerns structural aspects of their polypeptide backbones and microenvironments of certains amino acid residue side-chains. The work has been divided in two groups as related to the systems studied: a) Toxin γ from the ven
Publicado em: 1990
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28. Experimental syphilis: guinea pig model.
Outbred Hartley male guinea pigs (300-400 g) were infected intradermally with various concentrations of Treponema pallidum Nichols strain in the pubic region. The median lethal dose (ID50) was approximately 10(5). The animals produced lesions visible by darkfield microscopy, treponemal antibodies (IgG only), and histopathological changes in the lymphoid orga
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29. Ganciclovir prophylaxis for cochlear pathophysiology during experimental guinea pig cytomegalovirus labyrinthitis.
The effectiveness of the antiviral agent ganciclovir (9-[1,3-dihydroxy-2-propoxymethyl]guanine) against guinea pig cytomegalovirus was tested in vitro in guinea pig embryonic fibroblasts and in vivo in an experimental guinea pig cytomegalovirus labyrinthitis model. In vitro, ganciclovir completely prevented guinea pig cytomegalovirus infection of guinea pig
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30. Protective Immunity against Congenital Toxoplasmosis with Recombinant SAG1 Protein in a Guinea Pig Model
Primary infection with Toxoplasma gondii during pregnancy can induce fetal pathology and abortion in both humans and animals. The present study describes the development of an experimental model of congenital toxoplasmosis in the guinea pig. In this animal model, we evaluated the protective effect of vaccination with a recombinant form of SAG1 against matern
American Society for Microbiology.
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31. Guinea pig model for Staphylococcus aureus native valve endocarditis.
We present a new experimental model of Staphylococcus aureus infective endocarditis in guinea pigs. Permanent aortic valve damage was produced by electrocoagulation after catheterization of the right carotid artery, which allowed avoidance of the intracardiac catheter to produce cardiac vegetations. Our model closely mimics pathological mechanisms of native
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32. Studies on the Mode of Action of Diphtheria Toxin V. Protein Metabolism in a Guinea Pig Model Simulating Chronic Diphtheritic Toxemia
An experimental model of “chronic” diphtheria intoxication in the guinea pig was developed. Adult guinea pigs, subjected to a regimen of multiple sublethal doses of purified diphtheria toxin (total of 1.4 minimum lethal doses divided equally in four daily doses), developed a toxemia which terminated in death between 6 and 8 days. During an advanced stage
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33. Comparison of foscarnet cream, acyclovir cream, and acyclovir ointment in the topical treatment of experimental cutaneous herpes simplex virus type 1 infection.
Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetrated through guinea pig skin 7- to 10-fold
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34. Mechanisms of β-Adrenergic Modulation of IKs in the Guinea-Pig Ventricle: Insights from Experimental and Model-Based Analysis
Detailed understanding of IKs gating complexity may provide clues regarding the mechanisms of repolarization instability and the resulting arrhythmias. We developed and tested a kinetic model to interpret physiologically relevant IKs properties, including pause-dependence and modulation by β-adrenergic receptors (β-AR). IKs gating was evaluated in guinea-p
The Biophysical Society.
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35. Modifying Effect of Colicin on Experimental Shigella Keratoconjunctivitis
The ability of colicinogenic bacteria and colicin to inhibit Shigella sonnei during the course of infection was studied. Infection of the guinea pig conjunctivae was used as the experimental model. In S. sonnei-infected guinea pig conjunctivae which were treated with a colicinogenic strain of Escherichia coli or with colicin, the number of S. sonnei cells wa
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36. Action potential conduction between a ventricular cell model and an isolated ventricular cell.
We used the Luo and Rudy (LR) mathematical model of the guinea pig ventricular cell coupled to experimentally recorded guinea pig ventricular cells to investigate the effects of geometrical asymmetry on action potential propagation. The overall correspondence of the LR cell model with the recorded real cell action potentials was quite good, and the strength-