Estrogens Physiology
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Aspectos morfofuncionais da prostata feminina do gerbilo durante o cilco estral : estudos estruturais e caracterização do perfil secretor / Morphofunctional aspects of the gerbil female prostate during the estrous cycle : structural analysis and characterization on the secretory profile
The prostate is not an exclusive organ of the male reproduction system, found in females of several rodents species and also in humans. The female prostate has been considered homologue to the male ventral prostate and it is formed by a small cluster of glands and ducts inserted into a fiber muscular stroma. In adult female Mongolian gerbils (Meriones unguic
Publicado em: 2009
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2. Regulação hormonal da prostata de femeas do gerbilo : avaliação estrutural, citoquimica e imunocitoquimica / Hormonal regulation of the gerbil female propstate: morphology, cytochemistry and immunocytochemistry
The female prostate is a functionally active gland found in several species of mammals, including humans and rodents. In adult female gerbils, the prostate presents a paraurethral location, showing close contact with the wall of urethra in its median and distal portions. This gland is homologue to the ventral prostate of male rodents and it is formed by a cl
Publicado em: 2006
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3. Ação do estrógeno e progesterona na mucosa nasal humana: avaliação do transporte mucociliar nasal de sacarina e pesquisa de receptores hormonais através de método imuno-histoquímico / Estrogen and progesterone influence in human nasal mucosa: evaluation of nasal saccharin mucociliary transport and test for hormone receptors with immunohistochemical staining
Although nasal mucociliary clearance has been thoroughly studied, there is controversial evidence that it is directly influenced by female sex hormones. This study focused on: 1. evaluating saccharin nasal mucociliary transport in both sexes and during the follicular, periovulatory and luteal phases of consecutive ovarian cycles, and 2. identifying the expre
Publicado em: 2002
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4. Regulation of Postnatal Lung Development and Homeostasis by Estrogen Receptor β
Estrogens have well-documented effects on lung development and physiology. However, the classical estrogen receptor α (ERα) is undetectable in the lung, and this has left many unanswered questions about the mechanism of estrogen action in this organ. Here we show, both in vivo and in vitro, that ERβ is abundantly expressed and biologically active in the l
American Society for Microbiology.
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5. Progesterone receptors - animal models and cell signalling in breast cancer: Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer
Progesterone and estradiol, and their nuclear receptors, play essential roles in the physiology of the reproductive tract, the mammary gland and the nervous system. Estrogens have traditionally been considered associated with an increased risk of breast cancer. There is, however, compelling evidence that progesterone plays an important role in breast cell pr
BioMed Central.
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6. Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway
Estrogens are thought to regulate female reproductive functions by altering gene transcription in target organs primarily via the nuclear estrogen receptor-α (ER-α). By using ER-α “knock-out” (ERKO) mice, we demonstrate herein that a catecholestrogen, 4-hydroxyestradiol-17β (4-OH-E2), and an environmental estrogen, chlordecone (kepone), up-regulate t
The National Academy of Sciences of the USA.
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7. Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice
Estrogens are powerful modulators of neuronal physiology and in humans may affect a broad range of functions, including reproductive, emotional, and cognitive behaviors. We studied the contribution of estrogen receptors (ERs) in modulation of emotional processes and analyzed the effects of deleting ERα or ERβ in mice. Behavior consistent with increased anx
The National Academy of Sciences.
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8. Estrogens and Progesterone Promote Persistent CCND1 Gene Activation during G1 by Inducing Transcriptional Derepression via c-Jun/c-Fos/Estrogen Receptor (Progesterone Receptor) Complex Assembly to a Distal Regulatory Element and Recruitment of Cyclin D1 to Its Own Gene Promoter
Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G1-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs). Appropriate CCND1 gene activity is essential for normal development and physiology of the mammary gland, where it is regulated by ovarian steroids through a mecha
American Society for Microbiology.
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9. Estrogen receptor transcription and transactivation: Estrogen receptor knockout mice - what their phenotypes reveal about mechanisms of estrogen action
Natural, synthetic and environmental estrogens have numerous effects on the development and physiology of mammals. Estrogen is primarily known for its role in the development and functioning of the female reproductive system. However, roles for estrogen in male fertility, bone, the circulatory system and immune system have been established by clinical observ
BioMed Central.
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10. Impact of isotype-selective estrogen receptor agonists on ovarian function
Other isotype-selective estrogen receptor (ER) agonists, the selective ERα agonist 3,17-dihydroxy-19-nor-17α-pregna-1,3,5 (10)triene-21,16α-lactone and the selective ERβ agonist 8-vinylestra-1,3,5 (10)-triene-3,17β-diol, were used in hypophysectomized rats, gonadotropin-releasing hormone antagonist-treated mice, as well as intact rats to elucidate the e
National Academy of Sciences.
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11. Single-Chain Estrogen Receptors (ERs) Reveal that the ERα/β Heterodimer Emulates Functions of the ERα Dimer in Genomic Estrogen Signaling Pathways
The effects of estrogens, particularly 17β-estradiol (E2), are mediated by estrogen receptor α (ERα) and ERβ. Upon binding to E2, ERs homo- and heterodimerize when coexpressed. The ER dimer then regulates the transcription of target genes through estrogen responsive element (ERE)-dependent and -independent pathways that constitute genomic estrogen signal
American Society for Microbiology.