Erythropoiesis
Mostrando 1-12 de 306 artigos, teses e dissertações.
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1. Macrophages: key players in erythrocyte turnover
ABSTRACT The development of red blood cells (RBCs), or erythropoiesis, occurs in specialized niches in the bone marrow, called erythroblastic islands, composed of a central macrophage surrounded by erythroblasts at different stages of differentiation. Upon anemia or hypoxemia, erythropoiesis extends to extramedullary sites, mainly spleen and liver, a process
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Epoetin alfa resistance in hemodialysis patients with chronic kidney disease: a longitudinal study
Anemia is an inevitable complication of hemodialysis, and the primary cause is erythropoietin deficiency. After diagnosis, treatment begins with an erythropoiesis-stimulating agent (ESA). However, some patients remain anemic even after receiving this medication. This study aimed to investigate the factors associated with resistance to recombinant human eryth
Braz J Med Biol Res. Publicado em: 07/05/2018
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3. Iron deficiency in cancer patients
ABSTRACT Anemia is a frequent complication in cancer patients, both at diagnosis and during treatment, with a multifactorial etiology in most cases. Iron deficiency is among the most common causes of anemia in this setting and can develop in nearly half of patients with solid tumors and hematologic malignancies. Surprisingly, this fact is usually neglected b
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-12
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4. The role of magnetic resonance imaging in the evaluation of transfusional iron overload in myelodysplastic syndromes
Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective erythropoiesis. Anemia is a common finding in myelodysplastic syndrome patients, and blood transfusions are
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-08
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5. Aspectos da regulação do metabolismo do ferro nas hemoglobinopatias / Aspects of iron metabolism regulation in hemoglobinopathies
As hemoglobinopatias são distúrbios hereditários em que uma mutação genética leva a alteração da produção normal de hemoglobina, tal como na anemia falciforme e nas talassemias ß. Na maioria dessas doenças, ocorre anemia com necessidade transfusional variável, o que pode acarretar sobrecarga corporal de ferro. Na talassemia ß intermediária, oc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/09/2011
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6. Montano Pedroso, Juan Carlos. Variáveis hematológicas e perfil do ferro na abdominoplastia após a cirurgia bariátrica. / Hematological variables and iron status in abdominoplasty after bariatric surgery
Background: The treatment of the abdominal wall deformity resulted from weight loss after bariatric surgery is a mixed type of abdominoplasty, which can induce post-operative anemia. In addition, bariatric surgery itself promotes a tendency to iron deficiency which could compromise erythropoiesis. To our knowledge, there is no study evaluating the degree of
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/05/2011
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7. Perfil de expressão das PIP quinases durante a diferenciação eritroide humana in vitro / PIPK expression profile during in vitro differentiation of human erythroid cell
As fosfatidilinositol-fosfato quinases (PIPKs) são uma família de enzimas lipídio quinases responsáveis pela produção do segundo mensageiro PI4,5P2 (fosfatidilinositol 4,5 bifosfato), que tem um importante papel regulatório em uma variedade de processos celulares, inclusive na expressão gênica. As PIPKs são classificadas em 3 subfamílias -PIPK I (
Publicado em: 2009
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8. Impacto da doação de sangue nos depósitos de ferro do organismo de doadores
Iron is a vital element in the human metabolism. It plays a central role in erythropoiesis and is also involved in many other intracellular processes in all the tissues of the body. Blood donation results in a substantial (200 to 250 ng) loss of iron at each donation (425 to 475 ml) with subsequent mobilization of iron from body deposits. Repetitive donation
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2008-02
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9. Alterações Eritropoéticas e Leucopoéticas na Leishmaniose Visceral Canina
The bone marrow is considered an important reservoir of parasites in sick Leishmania-infected dogs. Little is know about the process cellular genesis in bone marrow in Canine Visceral Leishmaniasis (CVL) presenting different clinical status. In this context, the aim of the present study was to evaluate leucopoiesis and erythropoiesis alterations as well as t
Publicado em: 2008
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10. Assistência clínica materna e neonatal às diferentes condições obstétricas em bovinos da raça Holandesa / Maternal and neonatal clinical assistance under distinct obstetrical conditions in Holstein cattle
The novel reproductive biotechnologies (ET, IVF and Cloning) require more accurate control of pregnancy and parturition, due to obstetrical problems as a result of the large offspring syndrome or reduced calf vitality associated with placental anomalies. Hence, the reduction in neonatal mortality is justifiable as research in this area progresses, aiming mat
Publicado em: 2008
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11. DESENVOLVIMENTO E VALIDAÇÃO DE MÉTODO CROMATOGRÁFICO PARA AVALIAÇÃO DE POTÊNCIA DE ERITROPOIETINA HUMANA RECOMBINANTE. CORRELAÇÃO COM O ENSAIO BIOLÓGICO / DEVELOPMENT AND VALIDATION OF CHROMATOGRAPHIC METHOD FOR THE POTENCY ASSESSMENT OF RECOMBINANT HUMAN ERYTHROPOIETIN. CORRELATION WITH THE BIOLOGICAL ASSAY
Erythropoietin is a glycoprotein which stimulates the erythropoiesis, clinically used for the treatment of renal anaemia. The biological and chromatographic methods for the potency evaluation of recombinant human erythropoietin (rhEPO) in pharmaceutical products were validated in the present work. The normocythaemic mice bioassay was carried out in female BA
Publicado em: 2007
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12. Expressão genica global e estudo do gene JUNB em policitemia vera / Global gene expression and study of the JUNB gene in polycythemia
Polycythemia vera (PV) is a chronic myeloproliferative disorder that arises through clonal proliferation of multipotent hematopoietic progenitors. PV patients present bone marrow trilineage expansion, leading to increased production of mature red cells, granulocytes and platelets. Important PV features are elevated red cell mass, despite normal or subnormal
Publicado em: 2007