Ergosterol Biosynthesis
Mostrando 1-12 de 97 artigos, teses e dissertações.
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1. ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients
Abstract INTRODUCTION: Candidiasis is the most frequent opportunistic mycosis in humans and can cause mortality, particularly in immunodeficient patients. One major concern is the increasing number of infections caused by drug-resistant Candidas trains, as these cannot be efficiently treated with standard therapeutics. The most common mechanism of fluconazo
Rev. Soc. Bras. Med. Trop.. Publicado em: 07/03/2019
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2. Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa
The phytopathogenic fungus Moniliophthora perniciosa (Stahel) Aime & Philips-Mora, causal agent of witches' broom disease of cocoa, causes countless damage to cocoa production in Brazil. Molecular studies have attempted to identify genes that play important roles in fungal survival and virulence. In this study, sequences deposited in the M. perniciosa Genome
Genet. Mol. Biol.. Publicado em: 03/11/2014
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3. Ergosterol biosynthesis and drug development for Chagas disease
This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI). These compounds are currently the most advanced can
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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4. Analysis of secondary metabolites produced by endophytic fungi associated to Cupressus lusitanica / Análise de metabólitos secundários produzidos por fungos endofíticos associados à Cupressus lusitanica
Some phytopatogenic fungi found in Cupressus species produces phytotoxins very aggressive to the host plant. Surprisingly, these toxins are diterpenoids structures, as well as some endogenus metabolites in Cupressus species. This fungi ability appears to be a specialized strategy in the association fungi-plant. These observations motivated the development of
Publicado em: 2009
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5. Asian Rust control and performance of two soybean cultivars submitted to different fungicides and application time / Controle de ferrugem asiática e desempenho de duas cultivares de soja submetidas a diferentes fungicidas e épocas de aplicações
Phakopsora pachyrhizi Syd. &Syd. is the worst threat for soybean crop in the main producers regions around the world, where significant loses has been observed. Many variables in the quantification of damage of this disease have to be studied, such as area under the disease progress curve (AUDPC), healthy leaf area absorption (HAA), healthy leaf area duratio
Publicado em: 2009
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6. Identification and chromosomal localization of 9 Leishmania (L.) major loci related to resistance against two inhibitors of ergosterol biosynthesis pathway / Identificação e caracterização cromossomal de 9 loci de Leishmania (L.) major relacionados com resistência a inibidores da via de biossíntese do ergosterol
Ergosterol is an important compound responsible to maintain integrity and fluidity of Leishmania spp. membranes. Starting from an overexpression/selection method, our group has isolated nine different loci of L. (L.) major related to resistance against two inhibitors of the ergosterol biosynthesis pathway, Terbinafine (TBF) and Itraconazole (ITZ). Individual
Publicado em: 2008
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7. Characterization of resistance mechanisms to terbinafine in different species of Leishmania / Caracterização de mecanismos de resistência à terbinafina em diferentes espécies de Leishmania
O fenômeno de amplificação gênica é um mecanismo de auto-preservação celular observado com freqüência no protozoário parasita Leishmania quando submetido a estímulos negativos como, por exemplo, a presença de drogas. A região H do genoma de Leishmania (Leishmania) major é um dos loci mais estudados que leva à amplificação em resposta a droga
Publicado em: 2008
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8. Compostos organoestânicos com ação farmacológica
This work regards the mechanistic investigation of the biological activity of diorganotin complexes of aminobenzoic acid towards C. albicans cells (i); as well as the synthesis, characterization and biological activity of organotin derived of cholic acid (ii), 2,2-2,5-hiophenodiyl-bis(metilenenitrile)]-dibenzoic acid (iii) and 2-(3-oxociclohexen-1-enyl)amino
Publicado em: 2008
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9. Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans.
Eight antifungal agents were examined for effects on lipid biosynthesis and membrane integrity in Candida albicans. Lipids were labeled in vivo or in vitro with [14C]acetate and analyzed by thin-layer and gas chromatography. Membrane integrity was measured by a recently developed [14C]aminoisobutyric acid radiolabel release assay. The imidazole antifungal ag
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10. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate.
The thiocarbamate antimycotics tolnaftate and tolciclate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. There was no inhibition of other steps in ergosterol biosynthesis. In whole Candida cells, er
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11. Yeast Genome-Wide Expression Analysis Identifies a Strong Ergosterol and Oxidative Stress Response during the Initial Stages of an Industrial Lager Fermentation
Genome-wide expression analysis of an industrial strain of Saccharomyces cerevisiae during the initial stages of an industrial lager fermentation identified a strong response from genes involved in the biosynthesis of ergosterol and oxidative stress protection. The induction of the ERG genes was confirmed by Northern analysis and was found to be complemented
American Society for Microbiology.
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12. Genome-Wide Expression Patterns in Saccharomyces cerevisiae: Comparison of Drug Treatments and Genetic Alterations Affecting Biosynthesis of Ergosterol
Enzymes in the ergosterol-biosynthetic pathway are the targets of a number of antifungal agents including azoles, allylamines, and morpholines. In order to understand the response of Saccharomyces cerevisiae to perturbations in the ergosterol pathway, genome-wide transcript profiles following exposure to a number of antifungal agents targeting ergosterol bio
American Society for Microbiology.