Epoxidase
Mostrando 1-12 de 52 artigos, teses e dissertações.
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1. Avaliação da suplementação de um aditivo alimentar como um protetor potencial contra os efeitos adversos de 2,5ppm de toxina T-2 em frangos em crescimento
RESUMO Foi realizado um experimento com o objetivo de avaliar um aditivo alimentar contendo atividade de epoxidase de uma bactéria (Mycofix-S) como proteção potencial contra os efeitos adversos de uma dieta com 2,5ppm de toxina T-2 em frangos de corte machos. Um total de 144 pintos machos Ross 308 de um dia de idade foram marcados na asa individualmente e
Arq. Bras. Med. Vet. Zootec.. Publicado em: 2016-06
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2. Expressão de genes da via de biossíntese do Hormônio Juvenil em Melipona scutellaris (Hymenoptera, Apidae, Meliponini)
Em abelhas sem ferrão do gênero Melipona, nas quais a diferenciação de castas não depende somente da quantidade e/ou qualidade do alimento larval, o Hormônio Juvenil (HJ) tem sido apresentado como agente responsável, juntamente com fatores ambientais, por mecanismos genéticos que promovem as diferenças casta específicas. Na via de biossíntese do H
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/07/2011
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3. Ergosterol biosynthesis and drug development for Chagas disease
This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI). These compounds are currently the most advanced can
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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4. Characterization of resistance mechanisms to terbinafine in different species of Leishmania / Caracterização de mecanismos de resistência à terbinafina em diferentes espécies de Leishmania
O fenômeno de amplificação gênica é um mecanismo de auto-preservação celular observado com freqüência no protozoário parasita Leishmania quando submetido a estímulos negativos como, por exemplo, a presença de drogas. A região H do genoma de Leishmania (Leishmania) major é um dos loci mais estudados que leva à amplificação em resposta a droga
Publicado em: 2008
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5. Identification and characterization of a terbinafine resistance gene in L. major. / Isolamento e caracterização de gene que confere resistência à terbinafina em leishmania major
A amplificação gênica pode ser compreendida como um mecanismo de regulação de expressão protéica em Leishmania. A exposição a concentrações não letais de diferentes drogas isoladamente, como o metotrexato, a primaquina, cloroquina e antimônio levam à amplificação de regiões específicas como as localizadas no cromossomo 6 e no cromossomo 23.
Publicado em: 2008
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6. Study and Development of Theorical Modelo f Inhibition of the Enzyme Trypanothione Reductase of Leishmania spp. by a Class of N,N-diphenilbenzamidines. / Estudo e Desenvolvimento do Modelo Teórico de Inibição da Enzima Tripanotiona Redutase de Leishmania spp. por uma Classe de N,N-difenilbenzamidinas.
The present work aims to study and develop a theoretical model for the inhibition of trypanothione reductase from Leishmania spp by seven NN-diphenilbenzamidines, monosubstituted with the following groups: H, NO2, CH3, OCH3, CN, Br e Cl. Compounds were synthesized through a specific route and lately evaluated for a biological activity for some species of mic
Publicado em: 2007
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7. Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae.
The effect of oxygen on squalene epoxidase activity in Saccharomyces cerevisiae was investigated. In cells grown in standing cultures, the epoxidase was localized mainly in the "mitochondrial" fraction. Upon aeration, enzyme activity increased and the newly formed enzyme was associated with the "microsomal" fraction. At 0.03% (vol/vol) oxygen, epoxidase leve
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8. Dual Localization of Squalene Epoxidase, Erg1p, in Yeast Reflects a Relationship between the Endoplasmic Reticulum and Lipid Particles
Squalene epoxidase, encoded by the ERG1 gene in yeast, is a key enzyme of sterol biosynthesis. Analysis of subcellular fractions revealed that squalene epoxidase was present in the microsomal fraction (30,000 × g) and also cofractionated with lipid particles. A dual localization of Erg1p was confirmed by immunofluorescence microscopy. On the basis of the di
The American Society for Cell Biology.
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9. Violaxanthin de-epoxidase.
Violaxanthin de-epoxidase catalyzes the de-epoxidation of violaxanthin to antheraxanthin and zeaxanthin in the xanthophyll cycle. Its activity is optimal at approximately pH 5.2 and requires ascorbate. In conjunction with the transthylakoid pH gradient, the formation of antheraxanthin and zeaxanthin reduces the photochemical efficiency of photosystem II by i
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10. Aliphatic and chlorinated alkenes and epoxides as inducers of alkene monooxygenase and epoxidase activities in Xanthobacter strain Py2.
The inducible nature of the alkene oxidation system of Xanthobacter strain Py2 has been investigated. Cultures grown with glucose as the carbon source did not contain detectable levels of alkene monooxygenase or epoxidase, two key enzymes of alkene and epoxide metabolism. Upon addition of propylene to glucose-grown cultures, alkene monooxygenase and epoxidas
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11. Effects of squalene epoxidase inhibitors on Candida albicans.
The relationship between sterol biosynthesis inhibition, membrane integrity, and cell growth inhibition in Candida albicans was examined for five squalene epoxidase inhibitors. The compounds were the thiocarbamates tolnaftate and tolciclate and the allylamines naftifine, terbinafine, and SDZ 87-469. All compounds inhibited sterol biosynthesis, with the conce
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12. Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state
The vitamin K-dependent γ-glutamyl carboxylase catalyzes the posttranslational conversion of glutamic acid to γ-carboxyglutamic acid in precursor proteins containing the γ-carboxylation recognition site (γ-CRS). During this reaction, glutamic acid is converted to γ-carboxyglutamic acid while vitamin KH2 is converted to vitamin K 2,3-epoxide. Recombinant
The National Academy of Sciences of the USA.