Epigenetic
Mostrando 25-36 de 617 artigos, teses e dissertações.
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25. Morphological analysis and DNA methylation in Conyza bonariensis L. cronquist (Asteraceae) phenotypes
ABSTRACT The species Conyza bonariensis (L.) cause losses in agriculture due to their invasive capacity and resistance to herbicides like glyphosate. The species of this genus exhibit phenotypic plasticity, which complicates their identification and characterization. Thus, experiments were performed with 2 extreme C. bonariensis phenotypes (called broad leaf
Bragantia. Publicado em: 14/08/2017
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26. Detection of differentially methylated regions of irradiated fig tree selections
ABSTRACT Fig tree (Ficus carica L.) breeding programs using conventional methods, such as directed crosses, to obtain new cultivars, are unworkable in many countries, including Brazil. Consequently, genetic breeding through mutagenesis has emerged as an important line of research that can improve this crop, and be a significant source of information about th
Sci. agric. (Piracicaba, Braz.). Publicado em: 2017-08
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27. Epigenetic modifications and their relation to caste and sex determination and adult division of labor in the stingless bee Melipona scutellaris
Abstract Stingless bees of the genus Melipona, have long been considered an enigmatic case among social insects for their mode of caste determination, where in addition to larval food type and quantity, the genotype also has a saying, as proposed over 50 years ago by Warwick E. Kerr. Several attempts have since tried to test his Mendelian two-loci/two-allele
Genet. Mol. Biol.. Publicado em: 02/03/2017
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28. Effect of Embryo Thermal Stimulation on the Serum Levels of Immunoglobulins and Corticosterone, and Organ Histopathology of 1 day-old Broilers
ABSTRACT Embryo thermal stimulation has been studied as a means to promote epigenetic changes and to improve broiler health and performance. This study aimed at evaluating immunoglobulin (IgM, IgG, and IgA) titers, serum corticosterone levels, and organ integrity of day-old male Cobb(r) and Ross(r) broilers. Embryos were submitted to hot and cold stimuli (th
Rev. Bras. Cienc. Avic.. Publicado em: 2016-12
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29. Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease?
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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30. Epigénesis y preformacionismo: radiografía de una antinomía inconclusa
ABSTRACTThe process of development of the embryo has inspired philosophical speculation since the advent of Western thought. Since the time of Aristotle two antithetical conceptual models have traditionally been used to understand embryogenesis: either form or structure is preformed in the embryo or it is newly formed with each generation. Our aim in this ar
Sci. stud.. Publicado em: 2015-09
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31. Epigenetic Modifications: Therapeutic Potential in Cancer
Epigenetic modifications and alterations in chromatin structure and function contribute to the cumulative changes observed as normal cells undergo malignant transformation. These modifications and enzymes (DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases) related to them have been deeply studied to develop new drugs,
Braz. arch. biol. technol.. Publicado em: 2015-08
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32. DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence of cancer and age of disease onset are known to vary, even in patients carrying the same mutation, and several mechanisms such as genetic an
Braz J Med Biol Res. Publicado em: 28/04/2015
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33. Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line
DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes. Disruption of the DNA methyltransferase genes DNMT1 and DNMT3B in the HCT116 cell line (DKO cells) leads to global DNA hypomethylation and biallelic expression of the imprin
Braz J Med Biol Res. Publicado em: 17/10/2014
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34. Estudo de associação entre a susceptibilidade à esclerose múltipla e fatores relacionados ao HLA
Introduction: The multiple sclerosis (MS) is a chronic disease of the central nervous system that affects mainly young adults. This disease is characterized by the spread of demyelinating lesions in time and space. This condition may be influenced by genetic factors as heterogeneity, incomplete penetrance, polygenic inheritance and epigenetic factors, which
Arq. Neuro-Psiquiatr.. Publicado em: 2014-06
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35. A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability
Objective: To understand the risks of posttraumatic stress disorder (PTSD) development in the next generation of PTSD patients, we conducted a review on the biological, but not genetic, evidence of transgenerational transmission of PTSD vulnerability. Methods: Pertinent articles published from 1985 to September 2011 were searched using online academic searc
Rev. Bras. Psiquiatr.. Publicado em: 23/12/2013
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36. ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients
Membranous nephropathy (MN), characterized by the presence of diffuse thickening of the glomerular basement membrane and subepithelial in situimmune complex disposition, is the most common cause of idiopathic nephrotic syndrome in adults, with an incidence of 5-10 per million per year. A number of studies have confirmed the relevance of several experimental
Braz J Med Biol Res. Publicado em: 12/12/2013