Epigenetic Targets
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients
Objective: Bipolar I disorder (BD-I) is a type of bipolar spectrum disorder characterized by manic or mixed episodes. Detecting microRNA regulations as epigenetic actors in BD-I is important to elucidate the pathogenesis of the disease and reveal the potential of microRNAs (miRNAs) as biomarkers. Methods: We evaluated the expression profile of six candidate
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or between depression and mixed states, often associated with functional impairment. Although effective pharmacological and non-pharmacological treatments are available, several patients with BD remain symptomatic. The advance in the
Braz. J. Psychiatry. Publicado em: 2020-10
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3. Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and deve
Braz J Med Biol Res. Publicado em: 18/10/2018
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4. Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease?
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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5. Efeitos da associação entre vitamina A e ácido butírico em células de adenocarcinoma mamário humano da linhagem MCF-7 / Effects of the association between vitamin A and butyric acid on MCF-7 human breast adenocarcinoma cell line
O câncer de mama é a principal causa de morte por neoplasias em mulheres no mundo. Nutrientes, como vitamina A (VA) e ácido butírico (AB) podem modular a carcinogênese por meio de mecanismos epigenéticos, como acetilação de histonas e metilação do DNA. A associação de agentes desmetilantes do DNA e inibidores de desacetilases de histonas represen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/06/2010
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6. Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes / Class 1 Histone Deacetylases Gene Expression in Childhood Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia (ALL) is a heterogeneous disease with distinct biologic and prognostic groups. In addition to genetic alterations, epigenetic processes play an important role in carcinogenesis, among which histone acetylation/deacetylation is crucial for chromatin modulation structure and transcriptional activity. Histone acetylation is regulate
Publicado em: 2008
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7. Epigenetic targets in the diagnosis and treatment of prostate cancer
Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is being studied widely. The epigenetic changes are early event in the cancer development and are reversible.
International braz j urol. Publicado em: 2007-02
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8. ÉTUDE DES ALTÉRATIONS ÉPIGÉNÉTIQUES DES TUMEURS DES ENFANTS : LE CAS DES ÉPENDYMOMES ET DES NEUROBLASTOMES
During the last 10 years, a new mechanism of tumor development has been described: the hypermethylation of tumor suppressor genes. These epigenetic modifications were rarely studied in childhood cancer and large series of patients didnt exist before 2003. We studied two groups of childhood tumors; ependymoma and neuroblastome. Ependymomas (EP) represent the
Publicado em: 2006
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9. Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders
The major psychotic disorders schizophrenia and bipolar disorder are etiologically complex involving both heritable and nonheritable factors. The absence of consistently replicated major genetic effects, together with evidence for lasting changes in gene expression after environmental exposures, is consistent with the concept that the biologic underpinnings
Oxford University Press.
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10. The Binding Sites for the Chromatin Insulator Protein CTCF Map to DNA Methylation-Free Domains Genome-Wide
All known vertebrate chromatin insulators interact with the highly conserved, multivalent 11-zinc finger nuclear factor CTCF to demarcate expression domains by blocking enhancer or silencer signals in a position-dependent manner. Recent observations document that the properties of CTCF include reading and propagating the epigenetic state of the differentiall
Cold Spring Harbor Laboratory Press.
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11. Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
Early nutrition affects adult metabolism in humans and other mammals, potentially via persistent alterations in DNA methylation. With viable yellow agouti (Avy) mice, which harbor a transposable element in the agouti gene, we tested the hypothesis that the metastable methylation status of specific transposable element insertion sites renders them epigenetica
American Society for Microbiology.
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12. Epigenetic Modulation of Cancer-Germline Antigen Gene Expression in Tumorigenic Human Mesenchymal Stem Cells : Implications for Cancer Therapy
Cancer-germline antigens are promising targets for cancer immunotherapy, but whether such therapies will also eliminate the primary tumor stem cell population remains undetermined. We previously showed that long-term cultures of telomerized adult human bone marrow mesenchymal stem cells can spontaneously evolve into tumor-initiating, mesenchymal stem cells (
American Society for Investigative Pathology.