Endothelium Drug Effects
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta
ABSTRACT The objective of this study was to compare two alkaloids (antioquine and tetrandrine) with verapamil; knowing that the smooth muscle respond to KCl and relationships with calcium. The effects of antioquine and tetrandrine, was studied in adults Wistar rat with modified methods used in the determination of aorta contractility and compared with verapa
An. Acad. Bras. Ciênc.. Publicado em: 2018-04
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2. Methylene Blue to Treat Protamine-induced Anaphylaxis Reactions. An Experimental Study in Pigs
ABSTRACT Objective: To examine if methylene blue (MB) can counteract or prevent protamine (P) cardiovascular effects. Methods: The protocol included five heparinized pig groups: Group Sham -without any drug; Group MB - MB 3 mg/kg infusion; Group P - protamine; Group P/MB - MB after protamine; Group MB/P - MB before protamine. Nitric oxide levels were obtai
Braz. J. Cardiovasc. Surg.. Publicado em: 2016-06
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3. Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone
in vitro to rat aortic ringsAmfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vas
Braz J Med Biol Res. Publicado em: 27/03/2015
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4. Papel dos leucócitos na fisiopatologia da anemia falciforme / Role of leukocytes in sickle cell anemia pathophysiology
Sickle Cell Disease (SCD) is a disorder of hemoglobin synthesis, caused by a point mutation, and resulting in the production of abnormal sickle hemoglobin, HbS. The consequence of low oxygen levels is HbS polymerization, which is responsible for the vaso-occlusive phenomenon that is the hallmark of the disease. SCD is a chronic inflammatory disease character
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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5. Efeitos do polimorfismo T-786C do gene da óxido nítrico sintase endotelial (eNOS) e/ou da atorvastatina sobre parâmetros do metabolismo lipídico em adultos assintmáticos / Effects of the polymorphism T-786C of endothelial nitric oxide synthase (eNOS) gene and/or atorvastatin on parameters of lipid metabolism in asymptomatic adults
Nitric oxide (NO) is produced in the vascular endothelium by endothelial nitric oxide synthase (eNOS), an enzyme negatively regulated by the presence of the T-786C polymorphism, leading to endothelial dysfunction. High-density lipoproteins (HDL) have well-established anti-atherogenic functions, for example mechanisms that enhance eNOS activity. Statins are d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2010
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6. Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependent
Chronic lead exposure induces hypertension in humans and animals, affecting endothelial function. However, studies concerning acute cardiovascular effects are lacking. We investigated the effects of acute administration of a high concentration of lead acetate (100 µΜ) on the pressor response to phenylephrine (PHE) in the tail vascular bed of male Wistar ra
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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7. Efeitos pleiotrópicos com reduções equivalentes do LDL-colesterol: estudo comparativo entre sinvastatina e associação sinvastatina/azetimiba / Pleiotropic effects with equivalent LDL-cholesterol reduction: comparative study between simvastatin and simvastatin/ezetimibe coadministration
Introdução: A associação de uma estatina com ezetimiba é tão eficaz quanto altas doses da mesma estatina na redução do LDL-colesterol. Os efeitos que não dependem dessa redução são chamados de pleiotrópicos, entre os quais podemos citar: melhora da função endotelial, efeitos anti-oxidantes, efeitos anti- inflamatórios, entre outros. Objetivo:
Publicado em: 2007
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8. Avaliação in vitro e in vivo dos efeitos do ativador da guanilil ciclase soluvel BAY 41-2272 na ereção peniana / In vitro and in vivo effects of the soluble guanilyl cyclase BAY 41-2272 on penile erection
Penile erection is a physiologic event that includes psychic, neural and vascular mechanisms and involves the interaction of smooth muscle neural stimulation and releasing of relaxant and contractile agents from endothelium. The nitric oxide (NO) - soluble guanilyl cyclase (sGC) - cGMP system is the most significant and efficient mechanism of penile erection
Publicado em: 2006
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9. New insights into the anti-inflammatory actions of aspirin- induction of nitric oxide through the generation of epi-lipoxins
Aspirin has always remained an enigmatic drug. Not only does it present with new benefits for treating an ever-expanding list of apparently unrelated diseases at an astounding rate but also because aspirin enhances our understanding of the nature of these diseases processe. Originally, the beneficial effects of aspirin were shown to stem from its inhibition
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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10. Estudo dos efeitos do diabetes, da hipotermia e do bloqueio de óxido nítrico sintetase no escape vascular e na taquifilaxia do rim isolado de coelho / The effects of diabetes, hypothemia and nitric oxide sinthase blockade on vascular escape and tachyphylaxis in the rabbit isolated kidney
The endothelium plays a crucial role in the vascular tone, releasing relaxing and contracting factors among the first ones the gas nitric oxide, produced from the amino acid L-arginine and a group of enzimes called nitric oxide synthases (NOS). This study evaluated the effects of L-arginine as well as NOS inibitors on vascular escape and tachyphylaxis of rab
Publicado em: 2003
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11. Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.
Pharmacologic effects in brain caused by systemic administration of neuropeptides are prevented by poor transport of the peptide through the brain vascular endothelium, which comprises the blood-brain barrier in vivo. In the present study, successful application of a chimeric peptide approach to enhance drug delivery through the blood-brain barrier for the p
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12. Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production.
In intact blood vessels, many vasodilators act by stimulating the release from endothelium of factor(s) that relax vascular smooth muscle and stimulate increases in cGMP. To investigate how endothelium regulates cGMP production in vascular smooth muscle, bovine aortic endothelial cells and rat aortic smooth muscle cells were cultured both separately and toge