Endothelium Abnormalities
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Avaliação não-invasiva das propriedades da parede arterial em pacientes com doença de Behçet / Non-invasive evaluation of arterial wall properties in patients with Behçets disease
INTRODUÇÃO: O envolvimento vascular tem sido reconhecido como uma importante causa de morbidade e mortalidade na Doença de Behçet (DB), mas a importância de métodos não-invasivos em identificar lesões vasculares precoces ainda não foi bem estabelecida. OBJETIVO: Avaliar as propriedades estruturais e funcionais dos vasos na DB utilizando a medida da
Publicado em: 2010
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2. Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis
E-selectin is expressed by the activated endothelium and its plasma levels are increased in patients with systemic sclerosis. Eighteen patients fulfilling the American Rheumatism Association criteria for systemic sclerosis, 15 females and 3 males, 42-70 years old, 9 with diffuse and 9 with limited forms, were sequentially recruited for this study. Serum E-se
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-09
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3. Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension.
BACKGROUND: Pulmonary vascular tone may be modulated by endothelium-derived vasoactive mediators. Endothelial dysfunction is thought to occur in primary pulmonary hypertension. The aim of this study was to evaluate the vascular responses of patients with severe primary pulmonary hypertension to endothelium-dependent vasodilators (for example, substance P) an
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4. Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation
Oxford University Press.
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5. Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.
Abnormalities in endothelium-dependent arterial relaxation develop early in atherosclerosis and may, in part, result from the effects of modified low-density lipoprotein (LDL) on agonist-mediated endothelium-derived relaxing factor (EDRF) release and EDRF degradation. alpha-Tocopherol (AT) is the main lipid-soluble antioxidant in human plasma and lipoprotein
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6. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.
Recent evidence suggests that dietary therapy with lipid-soluble antioxidants may be beneficial for patients with atherosclerotic vascular disease but the potential mechanism(s) for these observations remain obscure. Abnormalities in endothelium-dependent control of vascular tone develop early in the course of atherosclerosis and may result from oxidative mo
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7. Histopathological findings in necropsy eyes with intraocular lenses.
The histopathological findings in five post-mortem eyes with anterior chamber and iris fixation intraocular lenses (IOLS) are discussed. The interval between lens insertion and death ranged from 3 1/2 to 52 months. Clinically the lenses were well tolerated and the surgery was considered to be successful. In one case a vitrectomy was required. Prominent histo
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8. Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis
Proximal renal tubular acidosis associated with ocular abnormalities such as band keratopathy, glaucoma, and cataracts is caused by mutations in the Na+-HCO3– cotransporter (NBC-1). However, the mechanism by which NBC-1 inactivation leads to such ocular abnormalities remains to be elucidated. By immunological analysis of human and rat eyes, we demonstrate
American Society for Clinical Investigation.
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9. Altered Gene Expression in Staphylococcus aureus upon Interaction with Human Endothelial Cells
Staphylococcus aureus is isolated from a substantial number of patients with infective endocarditis who are not known to have predisposing heart abnormalities. It has been suggested that the infection is initiated by the direct binding of S. aureus to human vascular endothelium. To determine the mutual response of the endothelial cells and the bacteria, we s
American Society for Microbiology.
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10. Endothelial control of lower limb blood flow in chronic heart failure.
BACKGROUND: Limitation of the blood supply to skeletal muscle in chronic heart failure may contribute to the symptoms of fatigue and diminished exercise capacity. The pathophysiology underlying this abnormality is not known. The purpose of this study was to assess the effect of endothelium dependent and independent vasodilator agents on blood flow in the leg
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11. A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development
Vascularization defects in genetic recombinant mice have defined critical roles for a number of specific receptor tyrosine kinases. Here we evaluated whether an endothelium-expressed receptor tyrosine phosphatase, CD148 (DEP-1/PTPη), participates in developmental vascularization. A mutant allele, CD148ΔCyGFP, was constructed to eliminate CD148 phosphatase
American Society for Microbiology.
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12. Granulocyte Colony-Stimulating Factor Improves Deficient In Vitro Neutrophil Transendothelial Migration in Patients with Advanced Liver Disease
Bacterial infections are frequent complications in patients with liver cirrhosis. Cirrhotic patients present abnormalities in both innate and adaptive immune responses, including a deficient neutrophil recruitment to infected sites. The purpose of this study was to assess neutrophil-endothelium interactions in cirrhotic patients and evaluate the effects of G
American Society for Microbiology.