Endocrine Disruption
Mostrando 13-24 de 31 artigos, teses e dissertações.
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13. Efeitos da exposição pré-púbere ao herbicida glifosato no desenvolvimento reprodutivo de ratos Wistar machos / Effects of the prepubertal exposure to glyphosate herbicide on reproductive development of male Wistar rats
The glyphosate-Roundup is a widely pesticide used in several culturas agrícolas. Its reproductive toxicity is associated to inhibition of StAR protein and aromatase enzime that cause in vitro significantly reduction in testosterone and estradiol production. The objective of this study was to evaluate the in vivo effects of inhibition of StAR protein and aro
Publicado em: 2007
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14. Endocrine disruption
Understanding the risks that endocrine disrupters pose to human health is limited by inadequate knowledge of the effects of chronic, low‐level and early‐life exposures in adult life
BMJ Group.
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15. Environment and health: 6. Endocrine disruption and potential human health implications
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16. Perils of paradigm: Complexity, policy design, and the Endocrine Disruptor Screening Program
The Endocrine Disruptor Screening Program (EDSP), mandated by the United States Congress in the Food Quality Protection Act of 1996, attempts to protect public health from adverse endocrine effects of synthetic chemical compounds by establishing a new testing regime. But the complexities and uncertainties of endocrine disruption and its broader regulatory an
BioMed Central.
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17. Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein common to all synaptic and endocrine vesicles. Unlike many proteins involved in synaptic exocytosis, SV2 has no homolog in yeast, indicating that it performs a function unique to secretion in higher eukaryotes. Although the structure and protein interactions of SV2 suggest multiple possible function
The National Academy of Sciences.
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18. The ultrastructure of the sheep placenta around the time of parturition.
Placental tissue, taken from seven sheep before, during and after delivery, was fixed and sectioned for study by transmission electron microscopy. Daily blood samples from the same sheep were taken from about 135 days p.c. and were analysed by radioimmunoassay for total unconjugated oestrogens. Sections of placentomal and interplacentomal areas were examined
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19. Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system
Thyroid hormone receptors (TRs) modulate various physiological functions in many organ systems. The TRα and TRβ isoforms are products of 2 distinct genes, and the β1 and β2 isoforms are splice variants of the same gene. Whereas TRα1 and TRβ1 are widely expressed, expression of the TRβ2 isoform is mainly limited to the pituitary, triiodothyronine-respo
American Society for Clinical Investigation.
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20. The Bisphenol A Experience: A Primer for the Analysis of Environmental Effects on Mammalian Reproduction1
It is increasingly evident that environmental factors are a veritable Pandora's box from which new concerns and complications continue to emerge. Although previously considered the domain of toxicologists, it is now clear that an understanding of the effects of the environment on reproduction requires a far broader range of expertise and that, at least for e
Society for the Study of Reproduction.
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21. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
Candidate transcription factors involved in pancreatic endocrine development have been isolated using insulin gene regulation as a paradigm. The cell-type restricted basic helix–loop–helix (bHLH) gene, BETA2/NeuroD, expressed in pancreatic endocrine cells, the intestine, and the brain, activates insulin gene transcription and can induce neurons to differ
Cold Spring Harbor Laboratory Press.
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22. Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption
The oocyte is the starting point for a new generation. Most of the machinery for DNA and protein synthesis needed for the developing embryo is made autonomously by the fertilized oocyte. However, in fish and in many other oviparous vertebrates, the major constituents of the egg, i.e. yolk and eggshell proteins, are synthesized in the liver and transported to
BioMed Central.
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23. The Xenoestrogen Bisphenol A Inhibits Postembryonic Vertebrate Development by Antagonizing Gene Regulation by Thyroid Hormone
Bisphenol A (BPA), a chemical widely used to manufacture plastics, is estrogenic and capable of disrupting sex differentiation. However, recent in vitro studies have shown that BPA can also antagonize T3 activation of the T3 receptor. The difficulty in studying uterus-enclosed mammalian embryos has hampered the analysis on the direct effects of BPA during ve
The Endocrine Society.
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24. Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in Gonadotropes
Inhibins are endocrine hormones that regulate gametogenesis and reproduction through a negative feedback loop with FSH. Inhibin action involves antagonism of signaling by activin or other TGFβ family ligands. In transfection assays, antagonism by inhibin can be potentiated by betaglycan, a coreceptor for selected TGFβ family ligands. We tested whether beta
The Endocrine Society.