Endochondral Ossification
Mostrando 1-12 de 47 artigos, teses e dissertações.
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1. Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats
OBJECTIVE: The growth plate consists of organized hyaline cartilage and serves as a scaffold for endochondral ossification, a process that mediates longitudinal bone growth. Based on evidence showing that the oral administration of glucosamine sul
Clinics. Publicado em: 2014
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2. Estudo da incidência de osteocondrose dissecante na articulação tíbio-társica de eqüinos (Equus caballus), de três anos de idade, da raça Brasileiro de Hipismo, no Estado de São Paulo, por meio de estudo radiográfico digital a campo / Study of the incidence of osteochondrosis dissecans in the tibiotarsal joints of three-year-old Brazilian Warmblood stallions (Equus caballus), in the state of Sao Paulo, using digital radiographic approach
This project provides information about osteochondrosis dissecans (OCD) affection in Brazilian Warmblood stallions, particularly in the state of Sao Paulo. Osteochondrosis dissecans is a developmental orthopaedic disease, which can involve both humans and animals. It is the most important skeletal disorder in growing foals. It is a failure of the endochondra
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2010
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3. Study of the osteoadherin presence during the intramembranous and endochondral ossification by immunocytochemistry and western blotting analysis / Estudo da presença de osteoaderina durante a ossificação intramembranosa e endocondral através de imunocitoquímica e Western Blotting
A osteoaderina (OSAD) tem sido identificada nos tecidos mineralizados, porém, seu papel na mineralização óssea não está claro. Foi feita uma comparação do momento em que a OSAD aparece na ossificação intramembranosa e endocondral, em relação aos estágios iniciais de mineralização. O osso parietal de fetos de ratos Wistar com 17, 18 e 21 dias e
Publicado em: 2010
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4. Avaliação temporal e espacial da expressão das metaloproteinases de matriz tipo de membrana (MT2, MT3, MT4, MT5 e MT6-MMP) durante a ossificação endocondral em camundongos / Temporal and spatial expression of membrane type-MMPs (MT2, MT3, MT4, MT5, and MT6-MMPs) during endochondral ossification in mice
As MMPs são endopeptidases zinco dependentes que, em conjunto, podem degradar todos os componentes da MEC e gerar moléculas bioativas. São as principais responsáveis pelo remodelamento tecidual durante eventos fisiológicos normais como a embriogênese e organogênese e também em eventos patológicos como a invasão tumoral nos tecidos. As pesquisas na
Publicado em: 2010
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5. Desenvolvimento osseo e dentario : aspectos biologicos, bioquimicos e moleculares da remodelação da matriz extracelular regulada pelas metaloproteinases de matriz e seus inibidores / Dental and bone development : biology, biochemistry, and molecular aspects of the matrix metalloproteinases and their inhibitors during extracellular matrix remodeling
Our objective was to analyse the spatial-temporal distribution of MMP-2, MMP-9, TIMP-1, TIMP-2 and RECK during development of mineralized tissue (bone, enamel, and dentine) in embryos, newborn, and adult mice by immunohistochemistry and in situ hybridization. During rat amelogenesis, at the secretion phase, MMPs and RECK were immunostained in the ameloblast
Publicado em: 2007
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6. Bone morphogenetic proteins: from structure to clinical use
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor ß superfamily. Family members are expressed during limb development, endochondral ossification, early fracture, and cartilage repair. The activity of BMPs was first identified in the 1960s but the proteins responsible for bone induction were un
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-10
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7. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.
Parathyroid hormone-related peptide (PTHrP) was initially identified as a product of malignant tumors that mediates paraneoplastic hypercalcemia. It is now known that the parathyroid hormone (PTH) and PTHrP genes are evolutionarily related and that the products of these two genes share a common receptor, the PTH/PTHrP receptor. PTHrP and the PTH/PTHrP recept
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8. Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs
Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking guanylyl cyclase B through gene targeting. Expression of the receptor mRNA in tissues such as bone and female reproductive organs was evident, and significant pheno
National Academy of Sciences.
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9. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. To determine the functional roles of Mmp13, we generated Mmp13-null
National Academy of Sciences.
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10. Constitutive E2F1 Overexpression Delays Endochondral Bone Formation by Inhibiting Chondrocyte Differentiation
Longitudinal bone growth results from endochondral ossification, a process that requires proliferation and differentiation of chondrocytes. It has been shown that proper endochondral bone formation is critically dependent on the retinoblastoma family members p107 and p130. However, the precise functional roles played by individual E2F proteins remain poorly
American Society for Microbiology.
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11. Dwarfism and early death in mice lacking C-type natriuretic peptide
Longitudinal bone growth is determined by endochondral ossification that occurs as chondrocytes in the cartilaginous growth plate undergo proliferation, hypertrophy, cell death, and osteoblastic replacement. The natriuretic peptide family consists of three structurally related endogenous ligands, atrial, brain, and C-type natriuretic peptides (ANP, BNP,
The National Academy of Sciences.
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12. Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide
Longitudinal bone growth is determined by the process of endochondral ossification in the cartilaginous growth plate, which is located at both ends of vertebrae and long bones and involves many systemic hormones and local regulators. Natriuretic peptides organize a family of three structurally related peptides: atrial natriuretic peptide, brain natriuretic p
The National Academy of Sciences.