Enantiomeros Do Cloridrato De Cis Tramadol
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1. Estereoselective analysis of cis-tramadol hydrocloride and its impurities in raw material and pharmaceutical formulation / Análise estereosseletiva do cloridrato de cis-tramadol e de suas impurezas em matéria-prima e formulação farmacêutica
Tramadol hydrochloride is a centrally acting analgesic with two chiral centers; the cis isomer is the active drug and the trans isomer is a process impurity. Both enantiomers of cis-tramadol hydrochloride contribute to the analgesic effect through different, but complementary and interactive pharmacological mechanisms. Although both isomers of cis-tramadol h
Publicado em: 2008