Efflux Pumps
Mostrando 1-12 de 143 artigos, teses e dissertações.
-
1. [PROVISIONAL] Genome sequence of Shewanella corallii strain A687 isolated from pufferfish (Sphoeroides spengleri)
Abstract We present here the genome sequence of Shewanella corallii strain A687 isolated from pufferfish Sphoeroides spengleri (Family Tetraodontidae). The assembly consists of 5,215,037 bp and contains 284 contigs, with a G+C content of 50.3%. The genus Shewanella comprises 67 recognized species. These bacteria are Gram-negative, rod-shaped, facultatively a
Genet. Mol. Biol.. Publicado em: 02/09/2019
-
2. Characterisation of an ABC transporter of a resistant Candida glabrata clinical isolate
BACKGROUND Candida glabrata ranks second in epidemiological surveillance studies, and is considered one of the main human yeast pathogens. Treatment of Candida infections represents a contemporary public health problem due to the limited availability of an antifungal arsenal, toxicity effects and increasing cases of resistance. C. glabrata presents intrinsi
Mem. Inst. Oswaldo Cruz. Publicado em: 05/02/2018
-
3. Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae
Abstract: INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years. Here, we investigated the relationship between tigecycline resistance and the expression of efflux pumps. METHODS: Clinical isolates of Acinetobact
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
-
4. Azole resistance in Candida spp. isolated from Catú Lake, Ceará, Brazil: an efflux-pump-mediated mechanism
Abstract Since, there is no study reporting the mechanism of azole resistance among yeasts isolated from aquatic environments; the present study aims to investigate the occurrence of antifungal resistance among yeasts isolated from an aquatic environment, and assess the efflux-pump activity of the azole-resistant strains to better understand the mechanism of
Braz. J. Microbiol.. Publicado em: 2016-03
-
5. Mutational and acquired carbapenem resistance mechanisms in multidrug resistant Pseudomonas aeruginosa clinical isolates from Recife, Brazil
An investigation was carried out into the genetic mechanisms responsible for multidrug resistance in nine carbapenem-resistant Pseudomonas aeruginosaisolates from different hospitals in Recife, Brazil. Susceptibility to antimicrobial agents was determined by broth microdilution. Polymerase chain reaction (PCR) was employed to detect the presence of genes enc
Mem. Inst. Oswaldo Cruz. Publicado em: 15/12/2015
-
6. Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica
OBJECTIVES: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree of synergistic activity of efflux pump inhibitors when combined with ciprofloxacin against resistant isola
Braz J Infect Dis. Publicado em: 2013-08
-
7. Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves t
Revista Brasileira de Farmacognosia. Publicado em: 12/08/2011
-
8. Alterações da permeabilidade e expressão de bombas de efluxo em isolados clínicos de Pseudomonas aeruginosa resistente ao imipenem / Permeability alterations and expression of efflux pumps in clinical isolates of imipenem-resistant Pseudomonas aeruginosa
Introdução: Isolados clínicos de Pseudomonas aeruginosa multirresistentes estão associados a elevadas taxas de mortalidade. A resistência ao imipenem é uma urgência global, uma vez que é considerado o tratamento de escolha para infecções associadas a bactérias Gram negativas multirresistentes. Assim, elucidar os mecanismos de resistência é de vi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/10/2010
-
9. Formation of soluble microbial products (SMP) in anaerobic reactors during stress conditions
Anaerobic wastewater treatment has many advantages over aerobic treatment, however, one factor that limits its application is the relatively high concentration of organic material in the effluent. Characterization of both aerobic and anaerobic effluents has shown that the majority of the residual chemical oxygen demand (COD) is due to soluble microbial produ
Publicado em: 2004
-
10. Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance
The effects of simultaneous expression of several efflux pumps on antibiotic resistance were investigated in Escherichia coli and Pseudomonas aeruginosa. Several combinations of efflux pumps have been studied: (i) simultaneous expression of a single-component efflux pump, which exports antibiotics into the periplasm, in combination with a multicomponent effl
American Society for Microbiology.
-
11. Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy
Whole-cell assays were implemented to search for efflux pump inhibitors (EPIs) of the three multidrug resistance efflux pumps (MexAB-OprM, MexCD-OprJ, MexEF-OprN) that contribute to fluoroquinolone resistance in clinical isolates of Pseudomonas aeruginosa. Secondary assays were developed to identify lead compounds with exquisite activities as inhibitors. A b
American Society for Microbiology.
-
12. Comparative aspects of Na+/K+ pump-mediated uncoupled Na+ efflux in red blood cells and kidney proteoliposomes.
Ouabain-sensitive uncoupled Na+ efflux has been studied in human, pig, and rat red cells and in vesicles containing reconstituted kidney Na+/K+ pumps obtained from these same species. The red cells from the different species gave qualitatively similar results; the uncoupled Na+ efflux was 15-30% of the Na+/K+ exchange rate, and this flux was inhibited at 5 m