Effector T Cell
Mostrando 1-12 de 871 artigos, teses e dissertações.
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1. Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed.
Braz J Med Biol Res. Publicado em: 16/02/2017
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2. The role of intradermal proliferation of T-cells in the pathogenesis of psoriasis
Abstract: BACKGROUND: Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evid
An. Bras. Dermatol.. Publicado em: 2017-02
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3. Follicular helper T cell in immunity and autoimmunity
The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh). These new subsets have many features in common, such as the ability to produce IL-21 and to express the
Braz J Med Biol Res. Publicado em: 19/04/2016
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4. B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization
In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells. Previous research has shown that the intramuscular immunization of BALB/c mice with a naked plasmid DNA fragment encoding the Mycobacterium leprae 65-kDa heat-shock protein (pcDNA3-Hsp65) induces prote
Braz J Med Biol Res. Publicado em: 18/09/2015
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5. T-cell receptor Vβ repertoire of CD8+ T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil
In human cutaneous leishmaniasis (CL), the immune response is mainly mediated by T-cells. The role of CD8+ T-lymphocytes, which are related to healing or deleterious functions, in affecting clinical outcome is controversial. The aim of this study was to evaluate T-cell receptor diversity in late-differentiated effector (LDE) and memory CD8+ T-cell subsets in
Mem. Inst. Oswaldo Cruz. Publicado em: 24/06/2015
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6. Plasticity of neutrophils reveals modulatory capacity
Neutrophils are widely known as proinflammatory cells associated with tissue damage and for their early arrival at sites of infection, where they exert their phagocytic activity, release their granule contents, and subsequently die. However, this view has been challenged by emerging evidence that neutrophils have other activities and are not so short-lived.
Braz J Med Biol Res. Publicado em: 23/06/2015
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7. Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus
Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE). TREG and effector T cells were analyzed for the expression of CTLA-4, PD1, CD28, CD95, GITR, HLA-DR, OX40, CD40L, and CD45RO in 26 pati
Braz J Med Biol Res. Publicado em: 2014-08
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8. Use of the heteroduplex mobility assay and cell sorting to select genome sequences of the CCR5 gene in HEK 293T cells edited by transcription activator-like effector nucleases
Engineered nucleases such as zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN) are one of the most promising tools for modifying genomes. These site-specific enzymes cause double- strand breaks that allow gene disruption or gene insertion, thereby facilitating genetic manipulation. The major problem associated with this
Genet. Mol. Biol.. Publicado em: 2014
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9. Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
The effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated. This study quantified and evaluated the function of memory T-cell subsets in response to soluble Leishmania antigens (SLA) from patients coinfected with HIV and Leishmania with tegumentary leishmaniasis (TL). E
Mem. Inst. Oswaldo Cruz. Publicado em: 02/10/2013
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10. Geração in vitro de células T efetoras e células T reguladoras mediada por células dendríticas pulsadas com vírus autólogo de pacientes infectados pelo HIV-1 / In vitro generation of effector T cells and regulatory T cells by monocyte-derived dendritic cells from HIV-1-infected patients pulsed with autologous virus
Imunização terapêutica utilizando células dendríticas derivadas de monócitos (MoDCs) pulsadas com antígenos de HIV constitui um meio promissor de potencializar a resposta imune específica anti-HIV em pacientes infectados. Neste contexto, é importante ressaltar que células dendríticas além de estimular a resposta imune específica, podem ser capaz
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/05/2012
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11. Prolonged acceptance of skin grafts induced by B cells places regulatory T cells on the histopathology scene
The participation of regulatory T (Treg) cells in B cell-induced T cell tolerance has been claimed in different models. In skin grafts, naive B cells were shown to induce graft tolerance. However, neither the contribution of Treg cells to B cell-induced skin tolerance nor their contribution to the histopathological diagnosis of graft acceptance has been addr
Braz J Med Biol Res. Publicado em: 2012-10
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12. Depletion of CD25+ cells during acute toxoplasmosis does not significantly increase mortality in Swiss OF1 mice
The interleukin (IL)-2R alpha chain (CD25) is expressed on regulatory T cells (Treg), which constitute more than 85% of the CD25+ T cell population in a naïve mouse. CD25 is also expressed on effector T cells in mice suffering from an acute infection by the obligate intracellular protozoan parasite, Toxoplasma gondii. Lethal toxoplasmosis is accompanied by
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-03