Eethylbenzene
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1. Influence of ethylbenzene on the pharmacokinetic enantiosselective of lercanidipine in rats. / Influência do etilbenzeno na farmacocinética enantiosseletiva do lercanidipino em ratos
Cytochrome P450 (CYP) is responsible for biotransformation of drugs, pollutants and other xenobiotics. Lercanidipine (LER), clinically employed as quiral compound in the treatment of arterial hypertension, is biotransformed by CYP3A4. Etylbenzene (EBZ), a solvent of large industrial use, is substrate and inducer of CYP3A in rats. The present study investigat
Publicado em: 2008