Drugs Kinetics
Mostrando 1-12 de 160 artigos, teses e dissertações.
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1. Development of a Method Based on DLLME and UFLC-DAD for the Determination of Antibiotics in Honey Samples and the Study of Their Degradation Kinetics
In this work, a method was developed, based on dispersive liquid-liquid microextraction (DLLME) and analysis by ultra-fast liquid chromatography coupled to diode array detector (UFLC-DAD), to simultaneously determine ten antibiotics of two different classes in honey, as well as to evaluate their degradation kinetics in this matrix. The extraction was optimiz
J. Braz. Chem. Soc.. Publicado em: 2018-07
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2. Chemical degradation kinetics of fibrates: bezafibrate, ciprofibrate and fenofibrate
ABSTRACT Fibrates are drugs used for the treatment of hypertriglyceridemia and for the prevention of atherosclerosis. Three drugs in the fibrate class, ciprofibrate, fenofibrate and bezafibrate, were chosen for this study because their raw materials are readily available and because scientific publications on these compounds is limited. To evaluate their int
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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3. Screening of wild type Streptomyces isolates able to overproduce clavulanic acid
The selection of new microorganisms able to produce antimicrobial compounds is hoped for to reduce their production costs and the side effects caused by synthetic drugs. Clavulanic acid is a β-lactam antibiotic produced by submerged culture, which is widely used in medicine as a powerful inhibitor of β-lactamases, enzymes produced by bacteria resistant to
Braz. J. Microbiol.. Publicado em: 2014-09
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4. Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate
Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tis
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-07
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5. Photodynamic therapy of Pythium insidiosum inactivation in vitro and in vivo study / Terapia fotodinâmica para inativação do Pythium insidiosum - estudo in vitro e in vivo
Photodynamic Therapy (PDT) is a therapy based on the interaction of photosensitizer and light, in the presence of oxygen, to induce cellular death. Under the incidence of light, at an appropriated wavelength, these chemical compounds produce reactive oxygen species which affects the biomolecules of the target-cells. Pythiosis is a lifethreatening emerging di
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
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6. Avaliação de anti-inflamatórios não esteroidais comerciais (AINES) sobre a atividade e função de PLA2 secretórias isolada dos venenos de Bothrops leucurus / Evaluation of comercial non-steroidal anti-inflammatory drugs (NSAIDs) on the activity and function of secretory PLA2 isolated from the venoms of Bothrops leucurus
Os Anti-inflamatórios não esteroidais (AINES) constituem uma classe de medicamentos com prescrição mundial, pois são fármacos que auxiliam na terapia de vários processos patológicos visto que oferecem ações farmacológicas: anti-inflamatória, analgésica e antipirética, como efeitos primários. A venda dos AINES no Brasil é de forma livre", por�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/08/2011
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7. Simulação Computacional e Análise de um Modelo Fenotípico de Evolução Viral. / Computer Simulation and Analysis of a Phenotypic Model of Viral Evolution
A large amount of viruses of medical importance such as HIV, respiratory syncytial virus, the hepatitis C virus, influenza A (H1N1) and polio virus, has RNA genome. These viruses exhibit extremely high mutational rate, fast replicative kinetics, large population of particles and high genetic diversity. Manifested during the infectious process, these features
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011
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8. Análise térmica aplicada a fármacos e formulações farmacêuticas na indústria farmacêutica
Several matters of the pharmaceutical demonstrate the great importance of thermal analysis application, especially TG and DSC for the pharmaceutical industry future, namely: characterization of the drugs with the thermal events definition, in studies of drug purity, in the polymorphs identification, in compatibility studies of solid dosage pharmaceutical for
Química Nova. Publicado em: 2011
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9. Mechanism of controlled release kinetics from medical devices
Utilization of biodegradable polymers for controlled drug delivery has gained immense attention in the pharmaceutical and medical device industry to administer various drugs, proteins and other bio-molecules both systematically and locally to cure several diseases. The efficacy and toxicity of this local therapeutics depends upon drug release kinetics, which
Brazilian Journal of Chemical Engineering. Publicado em: 2010-06
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10. Kinetics of cardiac and vascular remodeling by spontaneously hypertensive rats after discontinuation of long-term captopril treatment
Angiotensin-converting enzyme inhibitors reduce blood pressure and attenuate cardiac and vascular remodeling in hypertension. However, the kinetics of remodeling after discontinuation of the long-term use of these drugs are unknown. Our objective was to investigate the temporal changes occurring in blood pressure and vascular structure of spontaneously hyper
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
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11. Inibição da isocitrato liase de Paracoccidioides brasiliensis pelo produto natural argentilactona / Inhibition of isocitrate lyase by Paracoccidioides brasiliensis natural product argentilactone
The fungus Paracoccidioides brasiliensis is the causative agent of paracoccidioidomicosys (PCM), the most prevalent human systemic mycosis in Latin America. The toxicity of drugs and the appearance of resistant strains have imposition the search for new therapeutic approaches. Plants with reputed antimicrobial uses represent a rich source for the screening o
Publicado em: 2010
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12. Peptídeos antimicrobianos: síntese, ensaios biológicos, estudos termodinâmicos e análise estrutural por RMN em meios biomiméticos
Many organisms employ noxious chemicals (e.g., amines, steroid derivatives, alkaloids and peptides) to defend themselves against predators and pathogenic microrganisms. Among these chemical agents stand out peptides that can be found in a wide variety of organisms including bacteria, fungi, plants, insects, fish, amphibians,arachnids and mammals. The vast ma
Publicado em: 2010