Drug Receptors
Mostrando 13-24 de 404 artigos, teses e dissertações.
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13. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter
Braz J Med Biol Res. Publicado em: 15/10/2013
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14. BAFF promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis
Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology. A number of questions regarding its etiology are unclear. CD4+CD25+ regulatory T cells (Tregs) play a critical role in self-tolerance and, for unknown reasons, their relative number is reduced in PBC patients. B-cell-activating factor (BAFF)
Braz J Med Biol Res. Publicado em: 10/05/2013
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15. Ação do inibidor da enzima dipeptidil peptidase 4 sobre o pré-condicionamento isquêmico em pacientes portadores de diabetes mellitus tipo 2 e doença arterial coronariana estável / Effect of dipeptidyl peptidase-4 enzyme inhibitor on ischemic preconditioning in patients with type 2 diabetes and symptomatic coronary artery disease
Ischemic preconditioning (IPC) refers to the phenomenon in which short periods of myocardial ischemia and reperfusion promote resistance to a subsequent prolonged ischemic insult. Some hypoglycemic drugs, such as glibenclamide and repaglinide, are able to inhibit this protective phenomenon probably by its effects as blockers of adenosine triphosphate-depende
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/10/2012
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16. Estrogen and progesterone receptors in endometrial polyps of women exposed and not exposed to tamoxifen and in atrophic endometrium / Receptores de estrógeno e progesterona em pólipos endometriais de usuárias e não usuárias de tamoxifeno e no endométrio atrófico
Introduction: Tamoxifen has been used for the treatment of strogen receptor-positive breast cancer. The effect of tamoxifen in breast cancer is the it inhibition cancer cell growth by competitive antagonism with strogen for strogen receptor (ER). The mechanism of action of tamoxifen in this receptor varies among different tissues, with antagonist effect (e.g
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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17. Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide
Os glicocorticoides (GC) são prescritos por praticamente todas as especialidades médicas, e cerca de 0,5% da população geral do Reino Unido utiliza esses medicamentos. Com o aumento da sobrevida dos pacientes com doenças reumatológicas, a morbidade secundária ao uso dessa medicação representa um aspecto importante que deve ser considerado no manejo
Revista Brasileira de Reumatologia. Publicado em: 2012-08
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18. Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer
Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LD
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06
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19. Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems
Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V1 receptors or the central cholinerg
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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20. HIV-1 tropism and CD4 T lymphocyte recovery in a prospective cohort of patients initiating HAART in Ribeirão Preto, Brazil
While human immunodeficiency virus (HIV)-1 chemokine co-receptors 5 tropism and the GWGR motif in the envelope third variable region (V3 loop) have been associated with a slower disease progression, their influence on antiretroviral response remains unclear. The impact of baseline V3 characteristics on treatment response was evaluated in a randomised, double
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-02
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21. Avaliação da possível diferença na sensibilidade dolorosa de ratos machos e fêmeas e da resposta de cada sexo a crotalfina, um analgésico tipo opióide. / Sex differences in nociception and in the antinociceptive activity of crotalphine, an opioid-like analgesic drug.
Evidências clínicas e experimentais têm sugerido a existência de diferenças na sensação de dor e na resposta a fármacos analgésicos entre machos e fêmeas. A crotalfina (CRF), um peptídeo inicialmente isolado e caracterizado no veneno de serpentes Crotalus durissus terrificus, apresenta efeito antinociceptivo, quando avaliado em diferentes modelos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2011
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22. Expressão do receptor de macrófago com estrutura de colágeno (MARCO) em macrófagos, células dendríticas e células tumorais após internalização de nanotubos de carbono / Expression of macrophage receptor with collagen structure (MARCO) in macrophages, dendritic cells and tumor cells after internalization of carbon nanotubes
The aplication of nanotechnology emerges with potential for application in the biomedical area, pathological diagnosis and treatment, drug transport and intracellular transport of molecules. Among the nanoparticles, carbon nanotubes (NT) belong to a new class of material for application in the biomedical area. Due to its small size, the NT can be internalize
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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23. Efeito ansiolítico do ondansetron, antagonista dos receptores 5-HT3, injetado na amídala de camundongos submetidos à exposição e reexposição no labirinto em cruz elevado
Against of stimuli that are dangerous, animals manifest defense reactions that cause fear and anxiety. These stimuli activate the serotonergic system, which sends projections to structures involved in defense mechanisms such as the septum, hypothalamus, hippocampus, amygdala and periaqueductal gray modulates the behavioral changes that can be characterized a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2011
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24. Search for a platelet-activating factor receptor in the Trypanosoma cruzi proteome: a potential target for Chagas disease chemotherapy
Chagas disease (CD) causes the highest burden of parasitic diseases in the Western Hemisphere and is therefore a priority for drug research and development. Platelet-activating factor (PAF) causes the CD parasite Trypanosoma cruzi to differentiate, which suggests that the parasite may express PAF receptors. Here, we explored the T. cruzi proteome for PAF rec
Mem. Inst. Oswaldo Cruz. Publicado em: 2011-12