Drug Metabolism
Mostrando 1-12 de 510 artigos, teses e dissertações.
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1. CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, this molecule is a relevant candidate for drug development, but there is still no information on its human metabolism and systemic eliminat
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes
Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in vitro assays showed deviations from the Michaelian kine
Quím. Nova. Publicado em: 2021-06
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3. Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism
ABSTRACT Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment
Arch. Endocrinol. Metab.. Publicado em: 2021-04
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4. Choosing statins: a review to guide clinical practice
ABSTRACT Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the sett
Arch. Endocrinol. Metab.. Publicado em: 2020-12
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5. BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION
Micelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of cytotoxicity (MTT assay) revealed that the copolymers F127
Quím. Nova. Publicado em: 2020-09
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6. Serotonin syndrome associated with methadone and milk thistle seeds: a case report
Abstract Background Serotonin syndrome is rarely, potentially life threatening condition, associated with use of serotonin acting medications and psychoactive drugs. In the majority of cases the symptoms occur soon after the initiation of a new drug or a change in the dose. Objective To present a case report and to describe the possible mechanism of deve
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2020-06
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7. METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS
Metabolomics has played a central role in various areas of plant sciences, offering new perspectives for the advancement of agriculture, drug discovery, chemical ecology and taxonomy. Plant metabolomics (identification and quantification) aims to understand the relationship between biological systems and genetic, pathological and or environmental stimuli in
Quím. Nova. Publicado em: 2020-03
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8. Pharmacological treatment of pain in pregnancy
RESUMO JUSTIFICATIVA E OBJETIVOS: As causas não obstétricas de dor durante a gravidez são muito comuns e podem ser incapacitantes se não forem tratadas adequadamente. O objetivo deste estudo foi discutir o tratamento farmacológico da dor durante o período gestacional com foco na classificação de fármacos e o uso na gravidez, opções de terapia, te
BrJP. Publicado em: 02/12/2019
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9. Suspected adverse drug reactions reported for Brazilian children: cross-sectional study,
RESUMO Objetivo: Analisar relatos espontâneos de suspeitas de Reação Adversa a Medicamento (RAM) em crianças de 0 a 12 anos notificadas pela Agência Nacional de Vigilância Sanitária entre 2008 e 2013. Métodos: Um estudo transversal a partir de notificações de suspeitas de RAM relacionadas a medicamentos e produtos para a saúde em crianças foi r
J. Pediatr. (Rio J.). Publicado em: 25/11/2019
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10. Direct Assay to Evaluate Phosphoenolpyruvate Carboxykinase Activity
Phosphoenolpyruvate carboxykinase (PEPCK) is a ubiquitous enzyme found in all known groups of organisms, acting in the reversible conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) in the presence of divalent metal ion, and dependent of adenosine 5’-triphosphate (ATP) or guanosine-5’-triphosphate (GTP). PEPCK is an important enzyme in the meta
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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11. Influence of antiretroviral therapy on bone metabolism of patients with chronic hepatitis B: a review
Abstract Hepatitis B is a major public health problem worldwide and associated with significant mortality. To prevent or delay the deleterious effects of chronic infection by the hepatitis B virus, patients should be carefully followed, and antiviral therapy indicated according to specific recommendations. Currently, available drugs inhibit viral replication
Rev. Soc. Bras. Med. Trop.. Publicado em: 03/10/2019
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12. Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes
The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl hemisuccinate (CHEMS), and cholesterol (CHOL) via thin
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019