Drug Induced Abnormalities
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
Abstract Background: The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. Objective: The aim of this study was to analyze epidemiology and characteristics of severe cutaneous advers
An. Bras. Dermatol.. Publicado em: 2017-06
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2. A phase III, randomized, non-inferiority study comparing the efficacy and safety of biosimilar filgrastim versus originator filgrastim for chemotherapy-induced neutropenia in breast cancer patients
OBJECTIVES: To compare the efficacy and safety of two filgrastim formulations for controlling chemotherapy-induced neutropenia and to evaluate the non-inferiority of the test drug relative to the originator. METHODS: This phase III non-inferiority study had a randomized, multicenter, and open-label design. The patients were randomized at a ratio of 1:1 wit
Clinics. Publicado em: 2016-10
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3. Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab
AbstractTNF alpha antagonist-induced lupus-like syndrome is a rare condition which predominantly affects women (4:1). The average age of onset is 46-51 years. It occurs after exposure to TNF alpha antagonist and disappears after discontinuation of such agents. The pathogenic mechanism for development of the TNF alpha antagonist-induced lupus-like syndrome is
An. Bras. Dermatol.. Publicado em: 2015-06
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4. Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats
Background:Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitromodels of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. However, previous clinical studies with MVIIC demonstrated
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 09/05/2014
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5. Assessment and management of oral health in liver transplant candidates
Liver transplantation has become a standard treatment for end-stage liver disease and the number of recipients has grown rapidly in the last few years. Dental care during pre-transplant workup is important to reduce potential sources of infection in the drug-induced immunosuppression phase of liver transplantation. Objectives: The objectives of this study we
Journal of Applied Oral Science. Publicado em: 2012-04
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6. Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Sch
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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7. Rosiglitazona, agonista do PPAR-y "Peroxisome Proliferator-Activated Receptor-y" reverte a nefrotoxicidade induzida pelo tenofovir-DF / The peroxisome proliferator-activated receptor-y agonist rosiglitazone reverses tenofovir-induced nephrotoxicity
Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 1
Publicado em: 2008
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8. Toxicidade causada pela cocaína in vitro: participação da via dopaminérgica e do fator de transcrição NF-kB. / In vitro cocaine toxicity: participation of the dopaminergic pathway and the transcription factor NF-kB.
Cocaine is a drug deeply used and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newly born have been demonstrated due to the toxics effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damages is very complex and involves interactions of the drug with several neurotransmitt
Publicado em: 2008
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9. The study of biological meaning of multinucleation induced by vincristine in cultured cells / Estudo do significado biológico da multinucleação induzida por vincristina em células em cultura
The study of agents that interfere in the functionality of proteins related to cell cycle is important for the understanding of the transformation and cell death processes. Although ploidy alterations are presented in the majority of human tumors, their role in oncogenic process is not understood yet. The alteration on chromosomal number is the primary conse
Publicado em: 2006
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10. Estudo dos efeitos da inibiÃÃo crÃnica do Ãxido nÃtrico na reproduÃÃo de ratos machos / Study of the effect of the chronic inhibition of nitric oxide in the reproduction of male rats
Nitric Oxide (NO) derived from L-arginine by the nitric oxide synthase (NOS) which is expressed by various isoforms, is considered to be na important messenger molecule in several organ systems including the male genital tract. This study analysed the possible effects of L-NAME (NG-nitro-L-arginine methyl ester), a nonselective NOS inhibitor on testicilar de
Publicado em: 2002
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11. Capreomycin-induced serum electrolyte abnormalities
Gross electrolyte disturbances including hypokalaemia, hypomagnesaemia, hypocalcaemia, and alkalosis have developed in tuberculous patients who were being treated with capreomycin. Similar abnormalities have also occurred when the drug gentamicin was used and were found to be due to secondary hyperaldosteronism. In this paper a detailed description of the ch
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12. Pulmonary thromboembolism associated with procainamide induced lupus syndrome and anticardiolipin antibodies.
Procainamide is the commonest cause of a drug induced lupus syndrome. Long term administration of this compound may induce a variety of immunological abnormalities, including antinuclear antibodies. Uncommonly, 'lupus anticoagulants' have been demonstrated in the absence of other evidence of drug induced lupus. Details of a 67 year old man who developed not