Dorsal Periaqueductal Gray
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Envolvimento de mecanismos glutamatérgicos da substância cinzenta periaquedutal dorsal e do hipotálamo medial no medo condicionado à luz / Involvement of glutamatergic mechanisms of the dorsal periaqueductal gray matter and medial hypothalamus in conditioned fear to the light
A substância cinzenta periaquedutal dorsal (dPAG) e o hipotálamo medial (MH) são duas estruturas encefálicas que estão envolvidas na elaboração de estados aversivos e expressão de respostas defensivas. A estimulação elétrica da dPAG ou do MH produz uma série de respostas comportamentais que se assemelham às respostas defensivas induzidas pela pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/09/2012
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2. Involvement of NK-1 receptors of the basolateral and central nuclei of the amygdala in the defensive behavior of rats / Participação dos receptores NK-1 dos núcleos basolateral e central da amígdala no comportamento defensivo de ratos
A substantial body of evidence obtained in the last decade demonstrated that the Substance P (SP) is an important mediator of the affective and emotional behaviors. SP is a pro-aversive compound when microinjected within the dorsal periaqueductal gray (dPAG). These effects are mediated by the type 1 neurokininergic receptors (NK-1), since the defensive behav
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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3. Dorsal periaqueductal gray stimulation facilitates anxiety-, but not panic-related, defensive responses in rats tested in the elevated T-maze
The escape response to electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) has been associated with panic attacks. In order to explore the validity of the DPAG stimulation model for the study of panic disorder, we determined if the aversive consequences of the electrical or chemical stimulation of this midbrain area can be dete
Braz J Med Biol Res. Publicado em: 2012-11
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4. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression
The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The present study investigated the effects of the peripheral injection of the kappa-opioid
Braz J Med Biol Res. Publicado em: 2012-10
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5. New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray
Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the dorsal periaqueductal gray matter of the midbrain that organize defensive reactions to cope with proximal th
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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6. Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety
Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses, such as freezing and escape behavior. Freezing also ensues after termination of dPAG stimulation (post-stimulation freezing). These defensive reaction responses are critically mediated by γ-amin
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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7. Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters
This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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8. Contrasting effects of nitric oxide and corticotropin- releasing factor within the dorsal periaqueductal gray on defensive behavior and nociception in mice
The anxiogenic and antinociceptive effects produced by glutamate N-methyl-D-aspartate receptor activation within the dorsal periaqueductal gray (dPAG) matter have been related to nitric oxide (NO) production, since injection of NO synthase (NOS) inhibitors reverses these effects. dPAG corticotropin-releasing factor receptor (CRFr) activation also induces anx
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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9. Envolvimento de receptores NK-1 e NK-3 no comportamento defensivo induzido pela estimulação elétrica da substância cinzenta periaquedutal dorsal / Involvement of NK-1 and NK-3 receptors on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray.
A substância cinzenta periaquedutal dorsal (SCPd) é considerada uma das principais estruturas do teto mesencefálico envolvida no substrato neural da aversão a estímulos proximais. GABA e 5-HT são apontados como neurotransmissores envolvidos na modulação das respostas defensivas elaboradas na SCPd. Recentemente, mecanismos neurocininérgicos também t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2011
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10. Panic-like behaviors in Carioca High-and Low-conditioned Freezing rats
Panic disorder involves both recurrent unexpected panic attacks and persistent concern about having additional attacks. Electrical stimulation of the dorsal periaqueductal gray (dPAG) is an animal model of both panic attack and panic disorder, whereas contextual fear conditioning represents a model of anticipatory anxiety. Previous research indicated that an
Psychology & Neuroscience. Publicado em: 2011
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11. Gabaergic mechanisms of anterior and ventromedial hypothalamic nuclei in the expression of freezing in response to a light-conditioned stimulus
The amygdala, dorsal periaqueductal gray (dPAG), and medial hypothalamus have long been recognized to comprise a neural system responsible for the generation and elaboration of unconditioned fear in the brain. This neural substrate is well known to be under tonic inhibitory control exerted by γ-aminobutyric acid (GABA) mechanisms. Some evidence also suggest
Psychology & Neuroscience. Publicado em: 2011
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12. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate
Electrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) a
Psychology & Neuroscience. Publicado em: 2010-06