Dopamine Receptor D2
Mostrando 1-12 de 194 artigos, teses e dissertações.
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1. Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development
Abstract The reward sensation after food intake may be different between individuals and variants in genes related to the dopaminergic system may indicate a different response in people exposed to the same environmental factors. This study investigated the association of TaqIA (rs1800497) and -141C InsDel (rs1799732) variants in DRD2/ANKK1 gene with food int
Genet. Mol. Biol.. Publicado em: 23/07/2018
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2. Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence
Meningiomas are common, usually benign tumors, with a high postoperative recurrence rate. However, the genesis and development of these tumors remain controversial. We aimed to investigate the presence and implications of a mutated p53 protein and dopamine D2 receptor in a representative series of meningiomas and to correlate these findings with age, gender,
Braz J Med Biol Res. Publicado em: 03/03/2015
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3. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system
Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H
Braz J Med Biol Res. Publicado em: 07/11/2014
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4. 6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure
Impaired temporal control is symptomatic of several neurological disorders; recently, it has been implicated in schizophrenia. An animal model of schizophrenia using 6-hydroxydopamine (6-OHDA) infused to the medial pre-frontal cortex (mPFC) was employed to examine its effects on temporal control. Twelve rats were trained on a peak-interval procedure (PIP) un
Psychol. Neurosci.. Publicado em: 06/06/2014
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5. Análise dos polimorfismos 3420 e 3438 no gene do receptor da dopamina D2 em mulheres com diferentes desfechos reprodutivos : endometriose e aborto de repetição
Introdução: O aumento do nível sérico de prolactina tem sido associado com desfechos ginecológicos e obstétricos desfavoráveis, entre eles a endometriose e aborto recorrente. Sabendo que o polimorfismo do receptor da dopamina D2 (DRD2) está associado com hiperprolactinemia, realizamos este estudo para verificar sua associação com endometriose e com
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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6. Efeitos a longo prazo de diferentes separações dos filhotes no período neonatal sobre as genitoras
Esse estudo foi realizado para verificar se a exposição a separações repetidas (por diferentes intervalos de tempo) de mães dos seus filhotes no período neonatal poderiam ser classificadas como indutoras de um estado do tipo deprimido em genitoras. Sessenta ratas Wistar prenhes foram divididas em 3 grupos: controle, separação por 10 minutos e separa�
Publicado em: 2011
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7. InvestigaÃÃo da aÃÃo central do carvacrol em modelos de ansiedade, depressÃo e convulsÃo em camundongos e possÃveis mecanismos farmacolÃgicos envolvidos. / Investigation of central actions of carvacrol in animal models of anxiety, depression and convulsion in mice and possible pharmacological mechanisms involved.
Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of anxiety, depression, sedation and convulsion, such as, elevated plus maze (EPM), open field, rota
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/01/2010
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8. Effect of the administration of octreotide, cabergoline and the association of both on ACTH and cortisol levels in patients with Cushings disease: correlation of clinical response with tumoral expression of the dopamine (DRD2) and somatostatin (SSTR2 and SSTR5) receptors / Efeito da administração de octreotide, cabergolina e a associação de ambos nos níveis de ACTH e cortisol em pacientes com doença de Cushing: correlação da resposta clínica com a expressão tumoral dos receptores de dopamina (DRD2) e de somatostatina (SSTR2 e SSTR5)
Introdução: A doença de Cushing apresenta elevada morbimortalidade. Seu tratamento de escolha é a cirurgia transesfenoidal que possui resultados satisfatórios em cerca de 70% dos casos. Na doença persistente ou recorrente, reabordagem cirúrgica, radioterapia e adrenalectomia bilateral podem ser realizadas, porém, essas opções apresentam como desvan
Publicado em: 2010
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9. Estudo de derivados n-fenilpiperazínicos candidatos a protótipos de fármacos antipsicóticos de segunda geração / Study of n-phenylpiperazine derivatives candidates to second generation antipsychotic lead compounds
Este trabalho apresenta a continuidade da avaliação farmacológica das substâncias LASSBio-579, LASSBio-580 e LASSBio-581, através de ensaios in vitro e in vivo, em busca de um novo protótipo para o desenvolvimento de novos fármacos antipsicóticos de segunda geração. LASSBio-581 se liga a receptores D2-like (Ki=0,95 μM), 5-HT1A (Ki=1,2 μM) e 5-HT2
Publicado em: 2010
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10. Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice
Sleep disturbances have far-reaching effects on the neuroendocrine and immune systems and may be linked to disease manifestation. Sleep deprivation can accelerate the onset of lupus in NZB/NZWF1 mice, an animal model of severe systemic lupus erythematosus. High prolactin (PRL) concentrations are involved in the pathogenesis of systemic lupus erythematosus in
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-03
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11. Investigation of adenosine endogenous increase decurrent of D-Frutose-1,6-difosfato administration, a glycolytic intermediate. / Investigação do aumento endógeno de adenosina decorrente da administração do intermediário glicolítico D-Frutose-1,6-difosfato
D-Fructose-1,6-bisphosphate (F1,6BP), a high-energy glycolytic pathway intermediate, is reported to have a many pharmacologically effect, but its underlying mechanism of action in inflammation is incompletely understood. In this study, the aim was to examine the function of F1,6BP on cytokines and adenosine. Then, the possible F1,6BP anti-inflammatory activi
Publicado em: 2009
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12. Toxicidade causada pela cocaína in vitro: participação da via dopaminérgica e do fator de transcrição NF-kB. / In vitro cocaine toxicity: participation of the dopaminergic pathway and the transcription factor NF-kB.
Cocaine is a drug deeply used and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newly born have been demonstrated due to the toxics effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damages is very complex and involves interactions of the drug with several neurotransmitt
Publicado em: 2008