Disseminated Candidiasis
Mostrando 1-12 de 137 artigos, teses e dissertações.
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1. Oral Candida spp carriage and periodontal diseases in HIV-infected patients in Ribeirão Preto, Brazil
ABSTRACT The majority of HIV-infected patients develop Candida spp-associated clinical oral lesions. Studies have shown that asymptomatic oral colonization of Candida spp may lead to oral lesions or become a source of disseminated infections. The aim of this study was to verify the effects of periodontal conditions on Candida spp prevalence and Candida spp c
Rev. Inst. Med. trop. S. Paulo. Publicado em: 01/06/2017
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2. Therapeutic study of gomesina in mice with disseminated and vaginal candidiasis. / Estudo terapêutico da gomesina em camundongos com candidíase disseminada e vaginal.
A gomesina é um peptídeo antimicrobiano catiônico, purificado dos hemócitos da aranha caranguejeira Acanthoscurria gomesiana. Possui amplo espectro de atividade contra bactérias, fungos, protozoários e células tumorais. Candida albicans é uma levedura comensal que faz parte da microbiota humana. O tratamento desta micose geralmente é feito com fluco
Publicado em: 2009
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3. Modelagem farmacocinética-farmacodinâmica do antifúngico voriconazol
Objetivos: O objetivo deste trabalho foi o desenvolvimento de um modelo farmacocinético/farmacodinâmico (PK/PD) para descrever o efeito antifúngico voriconazol (VRC) contra espécies de Candida. Método: Para alcançar este objetivo as seguintes etapas foram realizadas: i) foi adaptado e padronizado modelo de candidíase disseminada em ratos Wistar imunoc
Publicado em: 2008
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4. SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits.
To investigate the potential use of SCH-39304 for the prevention and treatment of disseminated candidiasis in granulocytopenic patients, we studied its in vivo antifungal activity as preventive, early, and late treatments in three models (acute, subacute, and chronic) of disseminated candidiasis in persistently granulocytopenic rabbits. SCH-39304 was an effe
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5. Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line.
The role of T lymphocytes in disseminated candidiasis in a mouse model of irradiation-induced immunosuppression was investigated. A continuously cultured Candida albicans-specific T-cell line mediated protection of sublethally irradiated mice from disseminated candidiasis as measured by both the fungal load in the kidneys and mortality. These results are the
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6. Treatment of murine disseminated candidiasis with L-743,872.
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very pot
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7. Diagnosis of systemic candidiasis by latex agglutination for serum antigen.
Three latex agglutination test procedures for detecting Candida antigen in human serum were compared in a retrospective study of 69 patients and 20 normal volunteers. Untreated human serum was reacted with two different latex reagents; one reagent also was reacted with serum treated with protease and heat. The test procedure with treated serum was best, dete
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8. Comparison of antibody, antigen, and metabolite assays for hospitalized patients with disseminated or peripheral candidiasis.
Repeat serum samples from 22 patients with proven disseminated candidiasis and 42 with simple peripheral colonization were assayed for Candida antibodies by coelectrosyneresis, immunoprecipitation, and A and B immunofluorescence, for metabolites by D-arabinitol measurement, and for antigens by the mannan immunoassay and Cand-tec latex agglutination (mean num
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9. Detection of Candida antigenuria in disseminated candidiasis by immunoblotting.
Immunoblotting (Western blotting) was used to detect Candida albicans antigens in urine of 10 patients with disseminated candidiasis who had two or more positive blood cultures. Twelve urine samples were examined; and antigenuria was found in five of six patients with C. albicans infections, in one patient with a mixed Candida infection (including C. albican
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10. Vaccination with Recombinant N-Terminal Domain of Als1p Improves Survival during Murine Disseminated Candidiasis by Enhancing Cell-Mediated, Not Humoral, Immunity
Candida spp. are opportunistic fungal pathogens that are among the most common causes of nosocomial bloodstream infections. The mortality attributable to disseminated candidiasis is 40 to 50% despite antifungal therapy. Clearly, new strategies are needed to prevent this life-threatening infection. Because risk factors for disseminated candidiasis are well de
American Society for Microbiology.
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11. Treatment of experimental disseminated candidiasis with cilofungin.
The efficacy of cilofungin treatment of experimental disseminated candidiasis in rabbits was examined. Cilofungin treatment reduced yeast counts, especially in the kidney, with activity comparable to that of amphotericin B. The peak level of cilofungin in serum was measured at 5 min after administration of a single dose, with no drug detectable after 90 min.
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12. Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera.
Antigenic components in the cytoplasmic extract of Candida albicans were examined after fractionation by concanavalin A-Sepharose and DEAE-Sephacel ion-exchange chromatography. Fractions from the DEAE column were tested by fused rocket immunoelectrophoresis for their reactivity with antibodies in the sera of 20 patients with disseminated candidiasis. Three g