Disease Activity
Mostrando 1-12 de 5414 artigos, teses e dissertações.
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1. Quais as etapas para tratamento da artrite reumatoide?
Para o tratamento da artrite reumatoide são utilizados classe de medicamentos denominados “
medicamentos modificadores do curso da doença (MMCD): sintéticos
(MMCDs), biológicos (MMCDbio) e
. alvo específico sintéticos
(MMCDsae). A meta terapêutica é a remissão ou baixa atividade da doença. O tratamento inicial, pri
Núcleo de Telessaúde Santa Catarina. Publicado em: 12/06/2023
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2. Evaluation of nasal mucociliary clearance by saccharine test in rheumatoid arthritis
Abstract Objective: We aimed to reveal whether there is nasal involvement by examining the Nasal Mucociliary Clearance (NMC) and the relationship between this activity and disease severity in Rheumatoid Arthritis (RA) patients. Methods: In this prospective study, NMC time, disease activity (Disease Activity Score 28) and blood parameters of RA patients (n
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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3. Enthesitis-related arthritis: monitoring and specific tools
Abstract Objective: In this article, the authors aimed to review the different tools used in the monitoring of enthesitis-related arthritis. Sources: The authors performed a literature review on PubMed, Google Scholar, and Scopus databases. The dataset included the original research and the reviews including patients with enthesitis-related arthritis or ju
Jornal de Pediatria. Publicado em: 2022
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4. First-line biologic therapy with tumor necrosis factor inhibitors for psoriatic arthritis: a prospective observational study
ABSTRACT BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects multiple joints. It is associated with psoriasis and treated with synthetic and biologic drugs. OBJECTIVE: The objective of this study was to assess the outcomes of patients who received biologic therapy with tumor necrosis factor (TNF) inhibitors in terms of effe
Sao Paulo Medical Journal. Publicado em: 2022
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5. Clinical Significance of HSCARG for Atherosclerotic Coronary Heart Disease and Reduced ROS-Oxidative Stress in in Vivo and in Vitro Models via p47phox by NF-κB Activity
ABSTRACT Introduction: Coronary heart disease (CHD) is a dynamic process in which there are interactions between endothelial dysfunction, oxidative stress, and inflammatory responses. The aim of the present study was to investigate the function and mechanism of HSCARG in the treatment of CHD. Methods: Male apolipoprotein E/low-density lipoprotein receptor-
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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6. Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in d
Journal of the Brazilian Chemical Society. Publicado em: 2022
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7. RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients
Abstract Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investigate the RhoA/Rho-associated kinase (ROCK)-1 signaling pathw
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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8. Barriers to physical activity among adults in primary healthcare units in the National Health System: a cross-sectional study in Brazil
ABSTRACT BACKGROUND: Many factors may negatively impact physical activity (PA), but studies lack evidence of individual predictors of perceived barriers to PA among adults in primary healthcare units. OBJECTIVE: To analyze associations between sociodemographic characteristics, health conditions, leisure-time physical activity (LTPA), PA counseling and perc
Sao Paulo Medical Journal. Publicado em: 2022
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9. Physical and mental health impacts during COVID-19 quarantine in adolescents with preexisting chronic immunocompromised conditions
Abstract Objective: To evaluate physical and mental health indicators in adolescents with preexisting chronic immunocompromised conditions during coronavirus disease 2019 (COVID-19) quarantine. Methods: A cross-sectional study included 355 adolescents with chronic conditions and 111 healthy adolescents. An online self-rated survey was used to investigate s
Jornal de Pediatria. Publicado em: 2022
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10. Lysosomal acid lipase deficiency in pediatric patients: a scoping review
Abstract Objective: Lysosomal acid lipase deficiency (LAL-D) is an underdiagnosed autosomal recessive disease with onset between the first years of life and adulthood. Early diagnosis is crucial for effective therapy and long-term survival. The objective of this article is to recognize warning signs among the clinical and laboratory characteristics of LAL-D
Jornal de Pediatria. Publicado em: 2022
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11. Predictors of pain catastrophizing in women with systemic lupus erythematosus
SUMMARY OBJECTIVE: The aim of this study was to identify predictive factors associated with pain catastrophizing in women with systemic lupus erythematosus (SLE). METHODS: A total of 104 volunteered women with a diagnosis of systemic lupus erythematosus participated in the study. Pain Catastrophizing Scale, Body Awareness Questionnaire, Tampa Scale of Kine
Revista da Associação Médica Brasileira. Publicado em: 2022
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12. In vitro Antioxidant and Anticholinesterase Activities of Ouratea fieldingiana (Gardner) Eng. Leaf Extract and Correlation with Its Phenolics Profile with an in silico Study in Relation to Alzheimer’s Disease
Ouratea fieldingiana is a native medicinal plant from Northeastern Brazil and many biological properties are due to the phenolic constituents. The objective of this work was performing the characterization of O. fieldingiana leaf constituents to correlate with antioxidant and anticholinesterase activities by in vitro and in silico studies and thus contribute
Journal of the Brazilian Chemical Society. Publicado em: 2022