Differential Vaccine
Mostrando 1-12 de 72 artigos, teses e dissertações.
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1. A modified method by differential adhesion for enrichment of bladder cancer stem cells
ABSTRACT Purpose: In a previous study the vaccine was effective against bladder cancer in a mouse model. However, a small portion of tumors regrew because the vaccine could not eliminate bladder cancer stem cells (CSCs). In this study, we showed a modified method for the isolation of bladder CSCs using a combination of differential adhesion method and serum
Int. braz j urol.. Publicado em: 2016-08
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2. Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles
Flaviviruses cause severe acute febrile and haemorrhagic infections, including dengue and yellow fever and the pathogenesis of these infections is caused by an exacerbated immune response. Dendritic cells (DCs) are targets for dengue virus (DENV) and yellow fever virus (YF) replication and are the first cell population to interact with these viruses during a
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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3. BCGiosis as a presenting feature of a child with chronic granulomatous disease
Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which de
Brazilian Journal of Infectious Diseases. Publicado em: 2011-02
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4. Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica
Background: The common liver fluke Fasciola hepatica is the agent of a zoonosis with significant economic consequences in livestock production worldwide, and increasing relevance to human health in developing countries. Although flukicidal drugs are available, re-infection and emerging resistance are demanding new efficient and inexpensive control strategies
Publicado em: 2011
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5. Construction and characterization of a bovine herpesvirus 5 mutant with a deletion of the GI, GE and US9 genes
Bovine herpesvirus 5 (BoHV-5) is a important cause of viral encephalitis in cattle in South America. Within the framework of developing a differential vaccine against BoHV-5, a deletion mutant was constructed based on a Brazilian BoHV-5 isolate. The target of the deletions were genes that code proteins implicated in the neurovirulence of BoHV-5, the glycopro
Publicado em: 2010
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6. Construction and characterization of a glycoprotein e deletion mutant of bovine herpesvirus type 1.2 strain isolated in Brazil / Construção e caracterização de uma amostra de BoHV-1.2 isolada no Brasil com uma deleção no gene da glicoproteína E
Este artigo descreve a construção e caracterização de uma amostra de um herpesvírus bovino tipo 1.2a (BoHV-1.2a) que apresenta uma deleção na região genômica que codifica a glicoproteína E (gE). A deleção gênica foi induzida através da co-transfecção de um fragmento de deleção, contendo as regiões 5´e 3´flanqueadoras da gE, com o DNA vir
Publicado em: 2010
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7. ATTENUATION AND IMMUNOGENICITY OF A RECOMBINANT BOVINE HERPESVIRUS 5 DEFECTIVE IN GLYCOPROTEIN E AND THYMIDINE KINASE / ATENUAÇÃO E IMUNOGENICIDADE DE UMA CEPA RECOMBINANTE DO HERPESVÍRUS BOVINO TIPO 5 DEFECTIVA NA GLICOPROTEÍNA E E ENZIMA TIMIDINA QUINASE
O presente trabalho descreve a atenuação/virulência e imunogenicidade de uma cepa recombinante do herpesvírus bovino tipo 5 (BoHV-5) candidata a cepa vacinal. O recombinante BoHV-5gE/TKΔ foi construído a partir da cepa brasileira SV507/99 e contém deleções nos genes da glicoproteína E (gE) como marcador antigênico - e da enzima timidina quinas
Publicado em: 2010
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8. Avaliação das propriedades imunomoduladoras de toxinas termo-lábeis do tipo II produzidas por Escherichia coli enterotoxigênica (ETEC) administradas por via transcutânea. / Evaluation of the immunomodulatory properties of type II heat-labile toxins produced by enterotoxigenic Escherichia coli (ETEC) administered by transcutaneous route.
Heat-labile toxins expressed by enterotoxigenic Escherichia coli (LT-I, LT-IIa and LT-IIb) are potent systemic and mucosal adjuvants. These proteins have low identity (<14%) in their B subunits and bind to different receptors, which may result in differential biological properties. The objective of this work was to evaluate the immune response induced by LT-
Publicado em: 2009
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9. MAPEAMENTO E DELEÇÃO DE EPÍTOPOS LINEARES DE LINFÓCITOS B EM PROTEÍNAS DO VÍRUS DA SÍNDROME RESPIRATÓRIA E REPRODUTIVA DOS SUÍNOS PARA A PRODUÇÃO DE UMA VACINA DIFERENCIAL / MAPPING AND DELETION OF B-CELL LINEAR EPITOPES IN PROTEINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS FOR THE PRODUCTION OF A DIFFERENTIAL VACCINE
Porcine reproductive and respiratory syndrome virus (PRRSV) was isolated for the first time in 1991 and since then it has been associated with significant economic losses to the pig industry worldwide. Although vaccination against PRRSV is widely used, an important advance would be the development of marker vaccines allowing serologic discrimination between
Publicado em: 2008
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10. Construction of auxotrophic marker in Mycobacterium bovis BCG, knockout strain for the DPPD and proteomic study of tuberculin / Construção de marcador auxotrófico em Mycobacterium bovis BCG, de uma cepa knockout para DPPD e estudo proteômico da tuberculina
Mycobacterium bovis BCG has the potential to be an effective live vector for multivalent vaccines. However, there are two problems regarding the utilization of recombinant BCG as vaccine. The first one is that most mycobacterial cloning vectors rely on antibiotic resistance gene as selectable marker, which is used for genetic transformation. The second one i
Publicado em: 2008
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11. Experimental syphilis vaccines in rabbits. I. Differential protection with an adjuvant spectrum.
This study shows that 1 per cent. glutaraldehyde fixation of unwashed Treponema pallidum, Nichols pathogen, preserves the integrity of the outer envelope as well as the ruthenium-red (RR) staining extracellular slime layer. Since other researchers wash their treponemal suspensions before preparing their vaccines, it is likely that the vaccine preparations us
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12. Differential Interleukin-8 Response of Intestinal Epithelial Cell Line to Reactogenic and Nonreactogenic Candidate Vaccine Strains of Vibrio cholerae
In this study, we analyzed whether attachment of Vibrio cholerae vaccine strains to human intestinal epithelial cells can induce an interleukin-8 (IL-8) response. The IL-8 transcripts were detected by PCR amplification of reverse-transcribed mRNA, and the gene product secretion was measured by an enzyme-linked immunosorbent assay. Infection of monolayers of
American Society for Microbiology.