Differential Attenuation
Mostrando 13-24 de 49 artigos, teses e dissertações.
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13. Signature-Tagged Mutagenesis of Pasteurella multocida Identifies Mutants Displaying Differential Virulence Characteristics in Mice and Chickens
Pasteurella multocida is the causative agent of fowl cholera in birds. Signature-tagged mutagenesis (STM) was used to identify potential virulence factors in a mouse septicemia disease model and a chicken fowl cholera model. A library of P. multocida mutants was constructed with a modified Tn916 and screened for attenuation in both animal models. Mutants ide
American Society for Microbiology.
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14. Differential Regulation of Enteric and Systemic Salmonellosis by slyA
Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to regulate virulence genes involved in systemic, but not ente
American Society for Microbiology.
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15. Loss of Marek's disease virus tumorigenicity is associated with truncation of RNAs transcribed within BamHI-H.
The attenuation of Marek's disease virus (MDV) is associated with loss of pathogenicity and tumorigenicity. Previous studies have demonstrated a strong correlation between attenuation and amplification of a specific sequence located within the MDV terminal and internal repeats. We recently reported that the regions containing the amplified sequences, the Bam
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16. Role of attenuation in growth rate-dependent regulation of the S10 r-protein operon of E. coli.
We have investigated the transcription of the 11 gene S10 ribosomal protein operon of Escherichia coli under various growth conditions. The differential synthesis rate of structural gene message increases 2- to 2.5-fold immediately after a shift-up from glycerol minimal medium to glucose plus amino acids. After the initial increase, the transcription rate go
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17. Transcription of ribosomal genes during a nutritional shift-up of Escherichia coli.
We measured the differential transcription rates of individual ribosomal operons after a nutritional shift-up. All operons showed a transient increase in transcription. However, the response of the S10 ribosomal protein operon was much stronger than that of any other operon. We propose that only the S10 operon is autogenously regulated by a transcription att
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18. Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.
myc family genes (c-, N-, and L-myc) have been shown to be differentially expressed with respect to tissue type and developmental stage. To define and compare the regulatory mechanisms governing their differential developmental expression, we examined the transcriptional regulation of each myc family member during murine postnatal brain and liver development
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19. Initiation of transcription from the minute virus of mice P4 promoter is stimulated in rat cells expressing a c-Ha-ras oncogene.
Transformation of FR3T3 rat fibroblasts by a c-Ha-ras oncogene but not by bovine papillomavirus type 1 is associated with an increase in the abundance of mRNAs from prototype strain MVMp of infecting minute virus of mice, an oncosuppressive parvovirus. This differential parvovirus gene expression correlates with the reported sensitization of ras- but not bov
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20. Dynamic regulation of the tryptophan operon: A modeling study and comparison with experimental data
A mathematical model for regulation of the tryptophan operon is presented. This model takes into account repression, feedback enzyme inhibition, and transcriptional attenuation. Special attention is given to model parameter estimation based on experimental data. The model's system of delay differential equations is numerically solved, and the results ar
The National Academy of Sciences.
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21. Yields of Soviet underground nuclear explosions from seismic surface waves: Compliance with the Threshold Test Ban Treaty
Magnitudes of the larger Soviet underground nuclear weapons tests from the start of the Threshold Test Ban Treaty in 1976 through 1982 are determined for short- and long-period seismic waves. Yields are calculated from the surface wave magnitude for those explosions at the eastern Kazakh test site that triggered a small-to-negligible component of tectonic st
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22. Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits.
To investigate the mechanism by which angiotensin-converting enzyme (ACE) inhibition attenuates atherogenesis, we have studied the effects of a non-sulfhydryl ACE inhibitor, enalapril, and an angiotensin receptor antagonist, SC-51316, in cholesterol-fed rabbits. After 3 mo of enalapril treatment (10 mg/kg per d, p.o.) the percent plaque areas in the thoracic
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23. Segmental message stabilization as a mechanism for differential expression from the Zymomonas mobilis gap operon.
In Zymomonas mobilis, three- to fourfold more glyceraldehyde-3-phosphate dehydrogenase protein than phosphoglycerate kinase is needed for glycolysis because of differences in catalytic efficiency. Consistent with this requirement, higher levels of glyceraldehyde-3-phosphate dehydrogenase were observed with two-dimensional polyacrylamide gel electrophoresis.
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24. Differential sensitivity of radionuclide ventriculography for the detection of anterior and inferior infarction.
Attenuation of counts from the more distant inferior portion of the left ventricular blood pool in equilibrium radionuclide ventriculography may mean that inferior infarction is less likely to be detected than anterior infarction. Fourier amplitude and phase images can be used to map the extent and timing of regional ventricular wall motion and this study as