Diethylnitrosamine
Mostrando 25-26 de 26 artigos, teses e dissertações.
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25. O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.
We previously generated transgenic C3H/HeN mice by introducing the Escherichia coli O6-methylguanine-DNA methyltransferase (MGMT, DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase, EC2.1.1.63) gene, ada, attached to the Chinese hamster metallothionein I gene promoter. One transgenic mouse line expressing both ada-specific mRNA and Ada protein could
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26. Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones.
Hormonal and genetic factors strongly influence the susceptibility of inbred mice to hepatocarcinogenesis. Female C57BR/cdJ (BR) mice are extremely susceptible to liver tumor induction relative to other strains because they are genetically insensitive to the inhibition of hepatocarcinogenesis by ovarian hormones. To determine the genetic basis for the sensit