Diabetic Cardiomyopathy
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Diabetic cardiomyopathy: factual or factoid?
RESUMO Apesar de há muito tempo descrita, não existe consenso estabelecido quanto à real existência da cardiomiopatia diabética (CMPDM). Devido à sua complexa fisiopatologia, tem sido árduo à pesquisa clínica e experimental estabelecer conexões claras entre diabetes mellitus (DM) e insuficiência cardíaca (IC), assim como solucionar os mecanismos
Rev. Assoc. Med. Bras.. Publicado em: 2019-01
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2. Astragalus polysaccharides improve cardiomyopathy in STZ-induced diabetic mice and heterozygous (SOD2+/-) knockout mice
Oxidative stress plays an important role in the development of diabetic cardiomyopathy. In the present study, we determined whether the effect of astragalus polysaccharides (APS) on diabetic cardiomyopathy was associated with its impact on oxidative stress. Streptozotocin (STZ)-induced diabetic mice and heterozygous superoxide dismutase (SOD2+/-) knockout mi
Braz J Med Biol Res. Publicado em: 10/07/2017
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3. Endothelial function in pre-pubertal children at risk of developing cardiomyopathy: a new frontier
Although it is known that obesity, diabetes, and Kawasaki's disease play important roles in systemic inflammation and in the development of both endothelial dysfunction and cardiomyopathy, there is a lack of data regarding the endothelial function of pre-pubertal children suffering from cardiomyopathy. In this study, we performed a systematic review of the l
Clinics. Publicado em: 2012
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4. Cell therapy in dilated cardiomyopathy: from animal models to clinical trials
Dilated cardiomyopathy can be the end-stage form and common denominator of several cardiac disorders of known cause, such as hypertensive, ischemic, diabetic and Chagasic diseases. However, some individuals have clinical findings, such as an increase in ventricular chamber size and impaired contractility (classical manifestations of dilated cardiomyopathy) e
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-05
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5. Efeitos do exercício físico sobre as propriedades morfológicas e mecânicas de miócitos cardíacos de ratos diabéticos / Effects of exercise on the morphological and mechanical properties of cardiac myocytes from diabetic rats
The aim of this study was to verify the effects of a swimming training (ST) on the morphological and mechanical properties of cardiac myocytes from different regions of the left ventricle (LV) of rats with experimental diabetes. One month old male Wistar rats (body mass ~ 250g) received an intraperitoneal injection of Streptozootocin (STZ, 60mg/kg body mass)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/04/2010
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6. The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity
Recent work has demonstrated that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron-transport chain triggers several pathways of injury [(protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product formation (AGE)] involved in the pathogenesis of diabetic complications by inhibiting glyceraldehy
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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7. A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
To explore the role of peroxisome proliferator-activated receptor α (PPARα)-mediated derangements in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, insulinopenic mice with PPARα deficiency (PPARα−/−) or cardiac-restricted overexpression [myosin heavy chain (MHC)-PPAR] were characterized. Whereas PPARα−/− mice were protecte
The National Academy of Sciences.
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8. The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Recent evidence has defined an important role for PPARα in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARα in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice with cardiac-restricted overexpression of PPARα (MHC-PPAR) were produced and characterized. The expression of PPAR
American Society for Clinical Investigation.
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9. Cardiomyopathy in diabetic patients.
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10. Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy
Increased cardiovascular mortality occurs in diabetic patients with or without coronary artery disease and is attributed to the presence of diabetic cardiomyopathy. One potential mechanism is hyperglycemia that has been reported to activate protein kinase C (PKC), preferentially the β isoform, which has been associated with the development of micro- and mac
The National Academy of Sciences of the USA.
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11. Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy
American Diabetes Association.
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12. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein
Cardiomyocyte apoptosis is a critical process in the pathogenesis of ischemic and diabetic cardiomyopathy, but the mechanisms are not fully understood. Thioredoxin-interacting protein (TXNIP) has recently been shown to have deleterious effects in the cardiovascular system and we therefore investigated whether it may also play a role in diabetes-associated ca
American Physiological Society.