Developmental Toxicology
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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2. Cardio-respiratory development in bird embryos: new insights from a venerable animal model
ABSTRACT The avian embryo is a time-honored animal model for understanding vertebrate development. A key area of extensive study using bird embryos centers on developmental phenotypic plasticity of the cardio-respiratory system and how its normal development can be affected by abiotic factors such as temperature and oxygen availability. Through the investiga
R. Bras. Zootec.. Publicado em: 2016-11
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3. Estudo da toxicidade da Ipomoea carnea em ratas durante o período perinatal. Avaliação dos possíveis efeitos lesivos no tecido placentário / Ipomoea carnea toxicity study in rats during perinatal period. Evaluation of possible harmful effects on the placental tissue
A Ipomoea carnea é uma planta tóxica amplamente distribuída no Brasil e em outros países tropicais. Durante os períodos de seca esta planta se mantém verde, podendo servir como fonte de alimento para os animais de produção. A intoxicação natural é de caráter crônico e ocorre quando ruminantes particularmente, caprinos ingerem a planta, estes ani
Publicado em: 2009
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4. A model for prenatal toxicological studies in ruminants: evaluation of toxic effects caused by Senna occidentalis in goats / Proposta de modelo para o estudo de toxicologia perinatal em ruminantes: avaliação dos efeitos tóxicos da Senna occidentalis em caprinos
Senna occidentalis (So - formerly Cassia occidentalis), Fabaceae-Caesalpinoideae (Leguminosae) is a weed growing in pastures and in cultivated fields such as corn and soybeans in many tropical and subtropical areas worldwide. Many reports have shown that So is toxic to different animal species. Histologic lesions plant-related are degeneration skeltal and ca
Publicado em: 2008
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5. Toxicity of cyanide in swine: evaluation of perinatal effects / Toxicidade do cianeto em suínos. Avaliação dos efeitos perinatais
Cyanide and cyanogenic compounds are ubiquitous in nature and widely studied in toxicology. Long-term cyanide exposure has been associated to development of goiter, pancreatic diabetes, and several neurological diseases in humans and animals. However, the exact mechanism involved in induction of these diseases are not fully elucidated. It is believed that th
Publicado em: 2006
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6. Long-term effects of embryo freezing in mice.
Embryo cryopreservation does not induce clear-cut anomalies at detectable rates, but several mechanisms exist for nonlethal damage during the freeze-thaw process, and the risk of moderate or delayed consequences has not been extensively investigated. In a long-term study including senescence, we compared cryopreserved and control mice for several quantitativ