Developmental Toxicity
Mostrando 1-12 de 37 artigos, teses e dissertações.
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1. Erratum: Developmental Toxicity of (4S)-2- (4-hydroxy-3-methoxyphenyl) thiazolidine- 4-carboxylic acid in Zebrafish (Danio rerio)
Braz. arch. biol. technol.. Publicado em: 06/12/2018
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2. Expression analysis of cell wall assembly and remodelling-related genes in Arabidopsis roots subjected to boron stress and brassinosteroid at different developmental stages
ABSTRACT Plant cell walls are affected by many biotic and abiotic stress conditions. The aim of this study is to determine the effects of 24-Epibrassinolide (EBL) on some cell wall-related genes in root tissue of five- and ten-week-old Arabidopsis thaliana plants exposed to boron (B) deficiency (0 µM) or toxicity (3000 µM) at the transcriptional level. Exp
Acta Bot. Bras.. Publicado em: 09/04/2018
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3. Initial root length in wheat is highly correlated with acid soil tolerance in the field
ABSTRACT: In acid soils, toxic aluminum ions inhibit plant root growth. In order to discriminate aluminum (Al) tolerance, trustful screening techniques are required. In this study, 20 wheat cultivars, showing different levels of Al tolerance, were evaluated in a short-term soil experiment to access their relative root length (RRL). Moreover, the alleles of t
Sci. agric. (Piracicaba, Braz.). Publicado em: 2018-01
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4. Developmental Toxicity of (4S)-2- (4-hydroxy-3-methoxyphenyl) thiazolidine-4-carboxylic acid in Zebrafish ( Danio rerio )
ABSTRACT (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid is new synthesized substance obtained from cysteine and valine. Thiazolidine derivates have important biological responses so scientists work intensively on these compounds in recent years. It is obvious that thiazolidine contained compounds will be used in future in the pharmaceutical
Braz. arch. biol. technol.. Publicado em: 21/08/2017
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5. O estado atual do conhecimento sobre a exposição ambiental no organismo infantil durante os períodos sensíveis de desenvolvimento
Resumo: Objetivo: O presente estudo busca identificar as evidências científicas sobre os riscos e efeitos da exposição de contaminantes ambientais no organismo infantil durante os períodos sensíveis de seu desenvolvimento. Fonte de dados: As pesquisas foram feitas pelo banco de dados da Bireme, com os termos children's health, environmental exposure,
J. Pediatr. (Rio J.). Publicado em: 2017-02
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6. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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7. Traditional use and safety of herbal medicines
In the European Union, traditional herbal medicines that are regarded as "acceptably safe, albeit not having a recognized level of efficacy" fit into a special category of drugs ("traditional herbal medicine products") for which requirements of non-clinical and clinical studies are less rigorous. A regulation proposal published by the Brazilian National Heal
Rev. bras. farmacogn.. Publicado em: 2014-04
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8. Study on the developmental toxicity of a standardized extract of Orthosiphon stamineus in rats
Infusions of Orthosiphon stamineus Benth., Lamiaceae, leaves are widely used in Southeastern Asia to treat different illnesses. Nonetheless, no data is available on the safety of O. stamineus for pregnant women and their babies. This study was undertaken to evaluate the developmental toxicity of O. stamineus standardized aqueous extract in female Sprague Daw
Rev. bras. farmacogn.. Publicado em: 28/05/2013
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9. Herbs of interest to the Brazilian Federal Government: female reproductive and developmental toxicity studies
In 2009 the Brazilian Ministry of Health published a document named RENISUS that lists 71 herbs traditionally used in Brazil that could result in phytomedicines to be dispensed by the governmental health care program. This manuscript reviews female reproductive and/or developmental toxicity information of these herbs. More than half (35) of the herbs lack in
Revista Brasileira de Farmacognosia. Publicado em: 12/08/2011
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10. The developmental toxicity of cottonseed extraction on chicken embryo
Cottonseed meal is widely used as one of the protein supplement in poultry diets. Its mechanism of toxic action on chicken embryo is poorly understood. In this study, direct effects and abnormalities of cottonseed on chicken embryo were studied. Oxidative stress, cholinergic stress, mineral analysis and microscopic lesions were analyzed in chicken embryo whi
Revista Brasileira de Farmacognosia. Publicado em: 22/04/2011
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11. EFEITOS BIOQUÍMICOS E FISIOLÓGICOS DO CHUMBO EM PLANTAS DE QUITOCO (Pluchea sagittalis): POSSÍVEL PAPEL FITORREMEDIADOR / EFFECTS OF LEAD ON BIOCHEMICAL AND PHYSIOLOGICAL PARAMETERS IN QUITOC PLANTS (Pluchea sagittalis): POSSIBLE PHYTOREMEDIATOR ROLE
Lead (Pb) is one of the most abundant, globally distributed toxic elements. Soil, water and air contamination by Pb leads to its accumulation in fish, mammals, and plants, and thus to human intoxication through food. Due to the hazardous effects to the ecosystem, it is necessary that contaminated soils be rehabilitated. Phytoremediation is a cheap technique
Publicado em: 2010
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12. Avaliação da toxicidade reprodutiva de ratas Wistar submetidas à ingestão do extrato etanólico das folhas de nim(Azadirachta indica A. Juss)
Neem (Azadirachta indica A. Juss) is a plant of the Meliaceae family. It is commonly used in India as a contraceptive and worldwide as a means of controlling insect proliferation.In veterinary medicine it has been gaining attention due to its anti-helmintic and ectoparasitic properties. This study aims at evaluating the effects of oral administration of the
Publicado em: 2010