Developmental Programming
Mostrando 13-20 de 20 artigos, teses e dissertações.
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13. Environmental Programming of Heritable Epigenetic Changes in Paramutant R-Gene Expression Using Temperature and Light at a Specific Stage of Early Development in Maize Seedlings
Different heritable expression-states were programmed into R alleles from R/R-lst heterozygotes under different temperature conditions applied during a developmental period in which flowering is induced. At maturity, R-allele expressions in test crosses of male gametes derived from R/R-lst seedlings raised 15 days in 32° and continuous light conditions diff
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14. An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells
It has been believed that XIST RNA requires a discrete window in early development to initiate the series of chromatin-remodeling events that form the heterochromatic inactive X chromosome. Here we investigate four adult male HT-1080 fibrosarcoma cell lines expressing ectopic human XIST and demonstrate that these postdifferentiation cells can undergo chromos
National Academy of Sciences.
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15. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells
The developmental plasticity of transplanted adult stem cells challenges the notion that tissue-restricted stem cells have stringently limited lineage potential and prompts a re-evaluation of the stability of lineage commitment. Transformed cell systems are inappropriate for such studies, since transformation potentially dysregulates the processes governing
Oxford University Press.
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16. Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior
The long-term developmental and behavioral consequences of mammalian embryo culture are unknown. By altering the culture medium with the addition of FCS, we wanted to determine whether mouse embryos cultured under suboptimal conditions develop aberrant mRNA expression of imprinting genes at the blastocyst stage and whether fetal development, growth, and beha
National Academy of Sciences.
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17. Gibberellins and Seed Development in Maize. I. Evidence That Gibberellin/Abscisic Acid Balance Governs Germination versus Maturation Pathways1
Abscisic acid (ABA) is required for the regulation of seed maturation in maize (Zea mays L.). Mutants blocked in ABA synthesis (such as viviparous-5) do not mature to quiescent, desiccation-tolerant seeds, but germinate on the ear midway through kernel development. Because gibberellins (GA) and ABA act antagonistically in many aspects of plant development, w
American Society of Plant Physiologists.
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18. Alternative Splicing of Pre-mRNA in Cancer : Focus on G Protein-Coupled Peptide Hormone Receptors
Through alternative splicing, multiple different transcripts can be generated from a single gene. Alternative splicing represents an important molecular mechanism of gene regulation in physiological processes such as developmental programming as well as in disease. In cancer, splicing is significantly altered. Tumors express a different collection of alterna
American Society for Investigative Pathology.
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19. Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice
We recently reported insulin resistance in adult offspring of obese C57BL/6J mice. We have now evaluated whether parameters of skeletal muscle structure and function may play a role in insulin resistance in this model of developmental programming. Obesity was induced in female mice by feeding a highly palatable sugar and fat-rich diet for 6 wk prior to pregn
American Physiological Society.
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20. Fetal and Neonatal Exposure to the Endocrine Disruptor Methoxychlor Causes Epigenetic Alterations in Adult Ovarian Genes
Exposure to endocrine-disrupting chemicals during development could alter the epigenetic programming of the genome and result in adult-onset disease. Methoxychlor (MXC) and its metabolites possess estrogenic, antiestrogenic, and antiandrogenic activities. Previous studies showed that fetal/neonatal exposure to MXC caused adult ovarian dysfunction due to alte
The Endocrine Society.