Development Toxicology
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology
Abstract Toona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discusse
Rev. bras. farmacogn.. Publicado em: 2019-02
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2. Justicia pectoralis, a coumarin medicinal plant have potential for the development of antiasthmatic drugs?
ABSTRACT Justicia pectoralis Jacq., Acanthaceae, is a medicinal plant found Central America. In the Northeast of Brazil, it is popularly known as “chambá” being extensively used in homemade preparations for the treatment of cough, bronchitis and asthma. The species is part of a public phytotherapy program in Brazil entitled “Farmácias Vivas”, Natio
Rev. bras. farmacogn.. Publicado em: 2017-12
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3. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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4. Cardio-respiratory development in bird embryos: new insights from a venerable animal model
ABSTRACT The avian embryo is a time-honored animal model for understanding vertebrate development. A key area of extensive study using bird embryos centers on developmental phenotypic plasticity of the cardio-respiratory system and how its normal development can be affected by abiotic factors such as temperature and oxygen availability. Through the investiga
R. Bras. Zootec.. Publicado em: 2016-11
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5. Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats
Copaiba oil, extracted from Copaifera multijuga Hayne, Fabaceae, is widely used for medicinal purposes, especially to treat inflammatory processes. However, there is no report regarding its effect on reproductive performance after used in repeated doses orally. The present study evaluated the effects of the oral administration of Copaiba oil (at doses of 200
Rev. bras. farmacogn.. Publicado em: 2014-06
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6. Ishikawa, A. A. Development of analytical methodology for the investigation of methylenedioxy derivatives in samples of vitreous humor in fatal traffic accident. 2011. 67 f. Dissertation (Master) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2011. / Desenvolvimento de metodologia analítica para a investigação de metilenodioxi derivados em amostras de humor vítreo em vítimas fatais de acidentes de trânsito
The methylenedioxy derivatives are among synthetic drugs of illicit use most consumed in the occident, these are substances cause mental and motor disorders and has caused major threat to traffic safety, these effects affect the performance of drivers and may lead to traffic accidents. The vitreous humor is a biological matrix available in postmortem analysi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/10/2011
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7. AvaliaÃÃo da Piscicultura em Esgoto DomÃstico Tratado: Aspectos ZootÃcnicos, Ambientais e de Qualidade do Pescado Produzido / Evaluation of treated domestic sewage in fish: aspects of husbandry, environmental and quality of fish produced.
The use of wastewater is an alternative widespread nowadays. One way to reuse it in fish activity, considering that the effluent from Sewage Treatment Stations, are rich sources of nutrients that could be used by fish. However, some restrictions arise regarding the quality of animals for use in human diet. Thus, this research was conducted using treated sewa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2011
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8. Avaliação dos efeitos imunotóxicos da Ipomoea carnea e de seu princípio ativo tóxico, a suainsonina, em ratos jovens e adultos / Evaluation of the immunotoxic effects of Ipomoea carnea and its toxic principle, the swainsonine in young and adult rats
O presente estudo visou avaliar os efeitos da administração do resíduo aquoso final (RAF) da Ipomoea carnea e da suainsonina, sobre o sistema imune de ratos jovens em idade pré-pubere (21 dias) e adultos (70 dias). Para isso, o RAF foi administrado nas doses de 1,0; 3,0 e 7,0 g/kg e a suainsonina na dose de 5,0 mg/kg, por gavage, durante 14 dias para ava
Publicado em: 2010
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9. Development and application of an analytical method for the determination of fatty acid ethyl esters (biomarkers of ethanol) in meconium samples / Desenvolvimento e aplicação de método analítico para determinação de ésteres etílicos de ácidos graxos (bioindicadores do etanol) em amostras de mecônio
O álcool é uma das substâncias psicoativas mais consumidas mundialmente e seu uso por mulheres em idade reprodutiva, em particular, tem representado grande preocupação por parte de especialistas e da sociedade em geral. Apesar dos efeitos adversos associados ao ato de ingerir bebidas alcoólicas durante a gestação ser bastante documentados e conhecido
Publicado em: 2009
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10. Avaliação da toxicidade da Ipomoea carnea em caprinos durante o período perinatal: estudos de neuroteratologia / Evaluation of the toxicity of Ipomoea carnea in goats during postnatal period
Ipomoea carnea, a shrub plant, is a toxic plant largely distributed throughout Brazil and others topical countries. This plant possess swainsonine, an indolizidinic alkaloid as the most important active toxic principle, which promotes cellular accumulation of not metabolized oligossacarides, due to inhibition of acid or lisossomal αmanosidasis enzyme,
Publicado em: 2009
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11. Desenvolvimento e validação de metodologia analítica para a determinação de canabidiol e tetraidrocanabinol em amostras de plasma por cromatografia em fase gasosa/espectrometria de massas / Development and validation of an analytical methodology for determination of cannabidiol and tetrahydrocanabinol in plasma samples using gas phase chromatografy /mass espectrometry
Dissertation (Master). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, 2008. The Cannabidiol (CBD), that represents about 40% of the cannabinoids found in Cannabis sativa plant, is devoided of the typical psychological and cognitive effects of 9-Tetrahydrocannabinol (9THC). Researches suggest that CBD sho
Publicado em: 2008
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12. Development and application of toxicological analysis in the diagnosis and prognosis of acute intoxication by paraquat and diquat / Desenvolvimento e aplicação das análises toxicológicas no diagnóstico e prognóstico da intoxicação aguda por paraquat e diquat
Uma das classes químicas de herbicidas que merece particular atenção é a dos bipiridílicos, representada pelo paraquat e diquat. Atualmente, muitos países têm banido ou restringido o uso destes herbicidas devido à grande quantidade de casos de intoxicação acidental, suicídio e envenenamento (tentativa de homicídio) ocorridos no passado. Em contra
Publicado em: 2007