Desmogleins
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Autoantibodies against desmoglein 2 are not pathogenic in pemphigus
Abstract Background Anti-desmoglein 1 and 3 autoantibodies justify acantholysis in pemphigus; however, the pathogenesis of anti-desmoglein 2 is hypothetical. Objective To compare the participation of desmogleins 1, 2 and 3 through the production of serum autoantibodies, and protein and gene expression in the skin/mucosa of patients with pemphigus foliaceus
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Paraneoplastic pemphigus: a clinical, laboratorial, and therapeutic overview
Abstract: Paraneoplastic pemphigus is a rare and severe autoimmune blistering disease characterized by mucocutaneous lesions associated with benign and malignant neoplasms. Diagnostic criteria include the presence of chronic mucositis and polymorphic cutaneous lesions with occult or confirmed neoplasia; histopathological analysis exhibiting intraepidermal ac
An. Bras. Dermatol.. Publicado em: 17/10/2019
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3. Pemphigus vulgaris
Abstract: Pemphigus vulgaris is a chronic autoimmune bullous dermatosis that results from the production of autoantibodies against desmogleins 1 and 3. It is the most frequent and most severe form of pemphigus, occurring universally, usually between 40 and 60 years of age. It usually begins with blisters and erosions on the oral mucosa, followed by lesions o
An. Bras. Dermatol.. Publicado em: 29/07/2019
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4. Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient
Abstract: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. A 25-year-old male patient was admitted to our hosp
An. Bras. Dermatol.. Publicado em: 2017
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5. Avaliação da imunorreatividade contra desmogleína 1 e Trypanosoma cruzi em população de área endêmica para pênfigo foliáceo / Evaluation of immunoreactivity against desmoglein 1 and Trypanosoma cruzi in population from endemic area for pemphigus foliaceus
Introdução: O pênfigo foliáceo endêmico (PFE) ou Fogo Selvagem (FS) é uma dermatose bolhosa autoimune com auto-anticorpos IgG patogênicos, principalmente da subclasse IgG4, direcionados contra epítopos da desmogleína 1 (Dsg1), uma glicoproteína desmossômica que desempenha papel na adesão celular da epiderme. Os auto-anticorpos ligam-se a domínio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/09/2012
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6. Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis.
The adhesive core of the desmosome is composed of cadherin-like glycoproteins of two families, desmocollins and desmogleins. Three isoforms of each are expressed in a tissue-specific and developmentally regulated pattern. In bovine nasal epidermis, the three desmocollin (Dsc) isoforms are expressed in overlapping domains; Dsc3 expression is strongest in the
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7. Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome
Desmogleins (Dsgs), cadherin-type cell adhesion molecules, are targeted in skin-blistering diseases such as pemphigus and staphylococcal scalded skin syndrome (SSSS). The role of Dsg4, a new isoform, was investigated in these diseases. Dsg4 was recognized by 30 (77%) of 39 pemphigus sera containing anti-Dsg1 IgG but not by 16 pemphigus sera containing no ant
American Society for Clinical Investigation.
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8. Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris–like lesions
Pemphigus is an autoimmune disease of skin adhesion associated with autoantibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (Dsg) 1 and 3 and acetylcholine receptors. The notion that anti-Dsg antibodies alone are responsible for blisters in patients with pemphigus vulgaris (PV) stems from the ability of rDsg1 and r
American Society for Clinical Investigation.