Degenerative Bone Changes
Mostrando 13-18 de 18 artigos, teses e dissertações.
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13. Bone and joint symptoms in Paget's disease.
Fifty patients with Paget's disease of bone were reviewed with regard to the basis of their symptoms and the long-term results of treatment. Twenty-four patients (48%) presented with pain localised within bone, while 17 (34%) presented with symptoms of degenerative joint disease. Three patients presented with bone pain and arthritis and the remaining six wit
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14. Bone mineral density and bone turnover in spinal osteoarthrosis.
OBJECTIVES--To determine whether there was a generalised increase in bone mineral density (BMD) in spinal osteoarthrosis (OA), and to determine the mechanism of this possible protection against osteoporosis as assessed by biochemical markers of bone turnover. METHODS--We studied 375 women (ages 50 to 85) from a population based group. Spinal OA was defined f
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15. An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.
Studies were carried out on a line of transgenic mice that expressed an internally deleted COL2A1 gene and developed a phenotype resembling human chondrodysplasias (Vandenberg et al. 1991. Proc. Natl. Acad. Sci. USA. 88:7640-7644. Marked differences in phenotype were observed with propagation of the mutated gene in an inbred strain of mice in that approximat
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16. MRI of enthesitis of the appendicular skeleton in spondyloarthritis
Entheses are sites where tendons, ligaments, joint capsules or fascia attach to bone. Inflammation of the entheses (enthesitis) is a well‐known hallmark of spondyloarthritis (SpA). As entheses are associated with adjacent, functionally related structures, the concepts of an enthesis organ and functional entheses have been proposed. This is important in int
BMJ Group.
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17. Enzyme replacement therapy from birth in a feline model of mucopolysaccharidosis type VI.
We report evidence of a dose responsive effect of enzyme replacement therapy in mucopolysaccharidosis type VI cats from birth, at the clinical, biochemical, and histopathological level. Cats treated with weekly, intravenous recombinant human N-acetylgalactosamine-4-sulfatase at 1 and 5 mg/kg, were heavier, more flexible, had greatly reduced or no spinal cord
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18. Topographical variation in the calcified zone of upper femoral articular cartilage.
A series of 27 adult human femoral heads has been examined for topographical variation in 'remodelling' and other histological features of the calcified zone at the base of the articular cartilage. The specimens were obtained from necropsies; hip joints with osteoarthritic bone exposure were excluded. A tissue sample from the inferomedial aspect was compared