Deferoxamine
Mostrando 1-12 de 70 artigos, teses e dissertações.
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1. DEVELOPMENT OF AN ANALYTICAL METHOD FOR THE DETERMINATION OF LEAD BASED ON LOCAL SURFACE PLASMON RESONANCE OF SILVER NANOPARTICLES
Lead is environmental pollutant that even in low trace is harmful for human health and wildlife. In this study we presented a colorimetric method for determination of Pb2+ in water by aggregation of silver nanoparticles capped citrate in the presence of deferoxamine as chelating agent. Silver nanoparticles were prepared by reduction of AgNO3 with NaBH4. In t
Quím. Nova. Publicado em: 2020-06
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2. Deferoxamine synergizes with transforming growth factor-β signaling in chondrogenesis
Abstract Osteoarthritis, also known as degenerative arthritis or degenerative joint disease, is an epidemic disease that affects millions of people worldwide. Despite extensive recent work on the cellular biology of osteoarthritis, the precise mechanisms involved are still poorly understood and there is no effective treatment for this disease. The role of tr
Genet. Mol. Biol.. Publicado em: 14/08/2017
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3. Parâmetros oxidativos plasmáticos na determinação do desfecho e resposta ao tratamento com antioxidantes na sepse
OBJETIVOS: determinar a relação entre parâmetros de estresse oxidativo, gravidade de sepse e resposta ao tratamento com antioxidantes. MATERIAL E MÉTODOS: foram incluídos pacientes consecutivos admitidos na UTI de um hospital terciário com o diagnóstico de sepse, sepse grave ou choque séptico. Os pacientes foram avaliados diariamente e foi coletado s
Publicado em: 2007
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4. Baroreflex function in conscious rats submitted to iron overload
Our hypothesis is that iron accumulated in tissue, rather than in serum, may compromise cardiovascular control. Male Fischer 344 rats weighing 180 to 220 g were divided into 2 groups. In the serum iron overload group (SIO, N = 12), 20 mg elemental iron was injected ip daily for 7 days. In the tissue iron overload group (TIO, N = 19), a smaller amount of elem
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-02
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5. Urinary iron excretion induced by intravenous infusion of deferoxamine in ß-thalassemia homozygous patients
The purpose of the present study was to identify noninvasive methods to evaluate the severity of iron overload in transfusion-dependent ß-thalassemia and the efficiency of intensive intravenous therapy as an additional tool for the treatment of iron-overloaded patients. Iron overload was evaluated for 26 ß-thalassemia homozygous patients, and 14 of them we
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-11
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6. Acute iron poisoning. Rescue with macromolecular chelators.
Acute iron intoxication is a frequent, sometimes life-threatening, form of poisoning. Present therapy, in severe cases, includes oral and intravenous administration of the potent iron chelator, deferoxamine. Unfortunately, high dose intravenous deferoxamine causes acute hypotension additive with that engendered by the iron poisoning itself. To obviate this p
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7. Comparison of the Effects of Deferiprone versus Deferoxamine on Growth and Virulence of Yersinia enterocolitica
Deferoxamine, a drug used to treat patients with iron overload, has the capacity to promote systemic Y. enterocolitica infections in humans. The aim of this study was to determine whether deferiprone, the only orally active alternative treatment, has the same potential. When Y. enterocolitica IP864 was grown in an iron-poor chemically defined medium, additio
American Society for Microbiology.
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8. Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.
In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carin
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9. Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia.
The iron chelator deferoxamine and the polyamine biosynthesis inhibitor eflornithine (DL-alpha-difluoromethylornithine) were examined for anti-Pneumocystis carinii activity in the rat model of P. carinii pneumonia. The activity of deferoxamine at 250, 500, and 1,000 mg/kg given intraperitoneally provides evidence that iron chelation is a promising novel appr
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10. Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin.
Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could
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11. Tobramycin and FDA-Approved Iron Chelators Eliminate Pseudomonas aeruginosa Biofilms on Cystic Fibrosis Cells
The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to account for the inability of current therapies to resolve bacterial infections in the lungs of patients with cystic fibrosis (CF). We recently described a system in which highly antibiotic-resistant P. aeruginosa biofilms grow on human CF airway epithelial cells, and us
American Thoracic Society.
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12. Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages.
The zoopathogenic fungus Histoplasma capsulatum requires iron for growth. Intracellular growth of the fungus within mouse peritoneal macrophages is inhibited by recombinant murine gamma interferon (IFN-gamma). Such treatment of mouse peritoneal macrophages induces a marked downshift in transferrin receptors. We tested whether the antihistoplasma effect of IF