Damaging Agent
Mostrando 1-12 de 107 artigos, teses e dissertações.
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1. Comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. and Phaseolus vulgaris L. from gene banks
Abstract This study aimed to assess the feasibility of comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. (rice) and Phaseolus vulgaris (beans) L. from gene banks. Rice and beans were exposed to methyl methanesulfonate (MMS) as a reference DNA damaging agent. Seeds of two accessions of rice and beans were obta
Genet. Mol. Biol.. Publicado em: 2018-03
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2. Avoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Study
Abstract Objective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the
Braz. J. Cardiovasc. Surg.. Publicado em: 2017-06
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3. Characterization of anti-silencing factor 1 in Leishmania major
Anti-silencing factor 1 (ASF1) is a histone chaperone that contributes to the histone deposition during nucleosome assembly in newly replicated DNA. It is involved in chromatin disassembly, transcription activation and in the cellular response to DNA damage. In Leishmania major the ASF1 gene (LmASF1) is located in chromosome 20 and codes for a protein showin
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-05
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4. Toxic effects of cadmium on the microalgae Lingulodinium polyedrum using high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) / Análise dos efeitos tóxicos de cádmio sobre a microalga Lingulodinium polyedrum utilizando cromatografia líquida de alta eficiência acoplada à espectrometria de massas (LC-MS/MS)
Given the increase of environmentally harmful human activities, in particular the ones injurious to the aquatic environment, it is important to elucidate the defense mechanisms utilized by organisms exposed to damaging agents. Those species can later be suggested to be used as pollution bioindicators or bioremediatiors. Algae are of particular importance bec
Publicado em: 2010
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5. Biochemistry analyses of hormonal mutant Never ripe (Nr) to cadmium and salt stresses / Análise bioquímica do mutante hormonal de tomateiro Never ripe (Nr) submetido aos estresses por cádmio e salinidade
Plant exposure to abiotic and biotic stresses can lead to enhanced production of Reactive Oxygen Species (ROS) in cells, causing oxidative stress. Cadmium (Cd) and salt (NaCl) are among the most studied abiotic stresses. Salinity can cause ion disturb in the cell, resulting in osmotic stress. In the case of Cd, it can induce nutritional, structural and bioch
Publicado em: 2010
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6. PolidorÃdeos (Polychaeta: spionidae) em Crassostrea rhizophorae (Mollusca: bivalvia) de cinco rios da costa pernambucana
The Crassostrea rhizophorae occurs along the coast of Brazil serving as food to coastal communities and its production helps the local socio-economic development. Polydiariosis is one of several diseases in the world oyster culture. This disease is caused by a polychaete which drills the shell and inhabits a mud blister inside the oyster; thus, the oysterâs
Publicado em: 2009
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7. Randon Boolean networks in the presence of a damaging agent / DinÃmica de redes Booleanas aleatÃrias na presenÃa de agente danificador.
NÃs realizamos simulaÃÃes de computador em autÃmatos de Kauffman em diversos grafos tais como redes quadradas regulares e agregados de percolaÃÃo invasiva afim de investigar transiÃÃes de fase, entropia total, distribuiÃÃo radial do dano total mÃdio (expoente dinÃmico $z$) e velocidade de propagaÃÃo do dano quando se introduz um agente danifica
Publicado em: 2007
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8. Comet assay comparison of different Corbicula fluminea (Mollusca) tissues for the detection of genotoxicity
The comet assay was used to study the sensitivity of the widely distributed freshwater bivalve mollusk Corbicula fluminea to the DNA-damaging alkylating-agent methylmethane sulfonate (MMS). This study was undertaken to ascertain if C. fluminea is a good bioindicator of pollutants in aquatic environments and identify which C. fluminea tissue is most effective
Genetics and Molecular Biology. Publicado em: 2005-09
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9. DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli.
Operon fusions in Escherichia coli were obtained that showed increased beta-galactosidase expression in response to treatment with the DNA-damaging agent mitomycin C. These fusions were generated by using the Mud(ApR, lac) vector [Casadaban, M.J. & Cohen, S.N. (1979) Proc. Natl. Acad. Sci. USA 76, 4530-4533] to insert the lactose structural genes randomly in
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10. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
Cell-cycle checkpoint mechanisms, including the p53- and p21-dependent G2 arrest that follows DNA damage, are often lost during tumorigenesis. We have exploited the ability of DNA-damaging drugs to elicit this checkpoint, and we show here that such treatment allows microtubule drugs, which cause cell death secondary to mitotic arrest, to kill checkpoint-defi
American Society for Clinical Investigation.
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11. Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.
The product of the human immunodeficiency virus type 1 (HIV-1) vpr gene induces cell cycle arrest in the G2 phase of the cell cycle and is characterized by an accumulation of the hyperphosphorylated form of cdc2 kinase. This phenotype is similar to the effect of DNA-damaging agents, which can also cause cells to arrest at G2. We previously reported that Vpr
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12. Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
The MDM2 oncogene encodes an inhibitor of the p53 tumor suppressor protein that regulates p53 in a negative feedback loop. MDM2 gene amplification and overexpression occur in several types of tumors and are often associated with poor prognosis. An MDM2 antisense phosphorothioate oligodeoxynucleotide has been identified that effectively inhibits MDM2 expressi
National Academy of Sciences.