D Aminolevulinate Dehydratase
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive
ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a to
An. Acad. Bras. Ciênc.. Publicado em: 22/05/2017
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2. EFEITO ANTIOXIDANTE DE UMA NOVA CLASSE DE COMPOSTOS TELUROACETILENOS: ESTUDOS IN VITRO E IN VIVO / ANTIOXIDANT EFFECT OF A NOVEL CLASS OF TELLUROACETYLENE COMPOUNDS: STUDIES IN VITRO AND IN VIVO
Organotellurium compounds have been reported as antioxidants in several models of oxidative stress, especially in the brain. This study investigated the effect of telluroacetylenes a-d on pharmacological assays in vitro. A second objective of this study was to investigate the antioxidant action of compound b against the oxidative damage induced by sodium nit
Publicado em: 2010
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3. EFFECT OF THE ACUTE EXERCISE OF SHORT DURATION IN THE ENZYME δ-AMINOLEVULINATO DEHYDRATASE ACTIVITY IN HUMAN / EFEITO DO EXERCÍCIO AGUDO DE CURTA DURAÇÃO NA ATIVIDADE DA ENZIMA δ-AMINOLEVULINATO DESIDRATASE EM HUMANOS
Aerobic exercise of sufficient intensity and duration can result in increased generation of reactive oxygen species and exercise of extreme endurance may cause oxidative stress with a concomitant decreased activity of antioxidant defense systems. The aim of this study was to investigate the possible effect of a peak of oxidative stress exposition on the acti
Publicado em: 2009
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4. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Brazilian Journal of Medical and Biological Research. Publicado em: 21/08/2007
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5. Efeitos do chumbo sobre a atividade da tioredoxina redutase citosólica (TrxR1) e parâmetros de estresse oxidativo em rins de ratos. / Effects of lead acetate exposure on renal cytosolic thioredoxin reductase (TrxR1) activity and on indicators of lead exposure.
Lead is a heavy metal that accumulates primarily in kidney, where exerts its nephrotoxic effects. Several studies suggest that the oxidative stress is an important molecular mechanism for the toxic effects of lead in kidney and in other organs. Cytosolic thioredoxin reductase (TrxR1) is a selenoflavoprotein involved in many processes modulating intracellular
Publicado em: 2007
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6. Atividade da Delta Aminolevulinato desidratase sangüínea e o estresse oxidativo em pacientes hemodialisados / Human erythrocyte delta-aminolevulinate dehydratase activity and oxidative stress in hemodialysis patients
A ácido delta aminolevulinato desidratase (δ-ALA-D) é uma enzima tiólica, envolvida na biossíntese de compostos tetrapirrólicos, como o heme. Essa enzima é inibida por vários metais, sendo inclusive sua inibição um indicador de intoxicação por chumbo (Pb). Adicionalmente, muitos estudos sugerem sua inibição como um marcador do estresse oxid
Publicado em: 2007
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7. Efeito dos carotenóides licopeno e astaxantina sobre danos renais induzidos por cloreto de mercúrio. / Effect of lycopene and astaxanthin carotenoids on renal damage induced by mercuric chloride.
O mercúrio é um metal pesado com toxicidade comprovada, capaz de causar danos em qualquer tecido com o qual tenha contato, sendo o rim o principal alvo para sua forma inorgânica. O estresse oxidativo tem sido apontado como um importante mecanismo molecular para a injúria renal induzida por mercúrio inorgânico e a interação desse metal com moléculas
Publicado em: 2007
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8. EFFECTS OF CADMIUM ON d-AMINOLEVULINATE DEHYDRATASE FROM RAT LUNG IN VITRO: INTERACTION WITH CHELATING AND ANTIOXIDANT AGENTS / EFEITO DO CÁDMIO SOBRE A ENZIMA d-AMINOLEVULINATO DESIDRATASE DE PULMÃO DE RATOS IN VITRO: INTERAÇÃO COM AGENTES QUELANTES E ANTIOXIDANTES
A exposição das populações humanas a uma variedade de metais pesados é um problema de saúde pública. O cádmio é um elemento não essencial e devido ao seu imenso uso em diversas aplicações industriais, é um contaminante ambiental através da comida e da fumaça do cigarro. Este metal tóxico é mais eficientemente absorvido através dos pulmões
Publicado em: 2007
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9. Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism / Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALAD) no diabetes mellitus e no hipotireoidismo
The activity of Delta-Aminolevulinate Dehydratase (d-ALA-D) was analyzed in patients suffering from diabetes mellitus and primary hypothyroidism. Five groups of patients were studied: compensated diabetes mellitus, non-compensated diabetes mellitus, compensated hypothyroidism, non-compensated hypothyroidism and control group. The analysis of d-ALA-D in these
Publicado em: 2004
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10. A INIBIÇÃO DA ENZIMA δ-AMINOLEVULINATO DESIDRATASE POR MONOSSACARÍDEOS NÃO É MEDIADA PELA OXIDAÇÃO DE GRUPOS -SH
Heme pathway enzyme δ-aminolevulinate dehydratase (δ-ALA-D) is a good marker for oxidative stress and metal intoxication. This sulfhydrylic enzyme is inhibited in several oxidative pathologies like lead, mercury and aluminum intoxication, selenium organic species exposition and diabetes. Oxidative stress is one of cause of diabetes complications. T
Publicado em: 2004
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11. EFEITOS DO DISSELENETO DE DIFENILA NA ATIVIDADE DA ENZIMA δ-AMINOLEVULINATO DESIDRATASE E EM PARÂMETROS BIOQUÍMICOS DE RATOS COM DIABETES MELLITUS TIPO 1 / EFFECTS OF DIPHENYL DISELENIDE ON -δ-AMINOLEVULINATE DEHYDRATASE ACTIVITY AND BIOCHEMICAL PARAMETERS OF DIABETES MELLITUS TYPE 1 RATS
The hyperglycemia and oxidative stress are factors strongly involved on development of many disorders that characterize the Diabetes Mellitus. It is known that some organic and inorganic selenium compounds are potent antioxidant agents and present similar activity to the insulin in the control of hyperglycemia. Base on these data, the present study evaluated
Publicado em: 2004
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12. Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves
The interaction of the product of H2O2 and (PhSe)2 with delta-aminolevulinate dehydratase (delta-ALA-D) from mammals and plants was investigated. (PhSe)2 inhibited rat hepatic delta-ALA-D with an IC50 of 10 µM but not the enzyme from cucumber leaves. The reaction of (PhSe)2 with H2O2 for 1 h increased the inhibitory potency of the original compound and the
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-06