Cytochrome P 450 Enzyme System
Mostrando 1-12 de 75 artigos, teses e dissertações.
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1. Serotonin syndrome associated with methadone and milk thistle seeds: a case report
Abstract Background Serotonin syndrome is rarely, potentially life threatening condition, associated with use of serotonin acting medications and psychoactive drugs. In the majority of cases the symptoms occur soon after the initiation of a new drug or a change in the dose. Objective To present a case report and to describe the possible mechanism of deve
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2020-06
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2. Triagem, aplicação e engenharia de biocatalisadores para transformações enantio e regiosseletivas / Screening, applying and engineering biocatalysts for enantio and regioselective transformations
Biocatalysts have been widely applied in recent decades for industrial processes yielding high value products under environmentally friendly reaction conditions. The development of biocatalysts often begins with screening to identify enzymes with suitable activities followed by characterization of the enzymes chemo-, regio- and stereoselectivity or stability
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/06/2011
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3. Evaluation of polymorphism in the genes CYP1A1, CYP2D6 and CYP19 in patients with cancer of sporadic breast / Avaliação de polimorfismos nos genes CYP1A1, CYP2D6 e CYP19 em uma amostra de pacientes com cancer de mama esporadico
Breast cancer (BC) is a complex disease, with heterogeneous clinical and morphologic presentation, that has with different degrees of tumoral aggressiveness and metastatic potential. It is known that 90% to 95% of all the BC are sporadical and happens because of somatic mutations that occurs during life and that 5% to 10% are hereditary because of germinate
Publicado em: 2008
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4. Comparative study of the catalytic activity and proteinic expression of cytochrome P4501A (CYP1A) in suckermouth armored catfishes (Loricariidae) and tilapias (Cichlidae) / Estudo comparativo da atividade catalítica e expressão protéica do citocromo P4501A (CYP1A) em cascudos (Loricariidae) e tilápias (Cichlidae)
The cytochrome P450 (CYP) superfamily plays important roles in the biotransformation of xenobiotic and endogenous compounds. The CYP1A subfamily is well conserved in vertebrates and has been found in all jawed fish studied to date. In a previous study, we had found that suckermouth armored catfishes of the Loricariidae family (Hyposthomus luetkeni and H.affi
Publicado em: 2008
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5. Metalloporphyrins and salen complexes as a P450 biomimetic model for the metabolism of antiepileptic and antidepressant drugs / Metaloporfirinas e compostos salen como modelos biomiméticos do citocromo P450 no metabolismo de fármacos anticonvulsivante e antidepressivo
In this work, the catalytic activities of metalloporphyrins and the salen complex (Jacobsen catalyst) in solution and immobilized on different supports were studied in the oxidation of hydrocarbons, anticonvulsivant drugs (carbamazepine and primidone) and antidepressives (fluoxetine) by the following oxygen donors: hydrogen peroxide, terc-butyl hydroperoxide
Publicado em: 2008
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6. Modulação da atividade das enzimas de biotransformação de xenobióticos na malária murina letal e não-letal. / Modulation of the activity of enzymes of biotransformation of xenobiotics in the lethal and not-lethal murina malaria.
Durante as últimas três décadas, um expressivo número de estudos experimentais e clínicos mostrou que várias infecções e inflamações assépticas modulam a expressão e a atividade de enzimas citocromo P450 (CYP). Nesta linha de investigação, alguns estudos sugeriram que as atividades de CYP e a cinética de xenobióticos são alteradas também na
Publicado em: 2008
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7. Study and Development of Theorical Modelo f Inhibition of the Enzyme Trypanothione Reductase of Leishmania spp. by a Class of N,N-diphenilbenzamidines. / Estudo e Desenvolvimento do Modelo Teórico de Inibição da Enzima Tripanotiona Redutase de Leishmania spp. por uma Classe de N,N-difenilbenzamidinas.
The present work aims to study and develop a theoretical model for the inhibition of trypanothione reductase from Leishmania spp by seven NN-diphenilbenzamidines, monosubstituted with the following groups: H, NO2, CH3, OCH3, CN, Br e Cl. Compounds were synthesized through a specific route and lately evaluated for a biological activity for some species of mic
Publicado em: 2007
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8. Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis
The objective of this paper was to evaluate the hepatobiliary function of patients with pulmonary tuberculosis under triple treatment, using the technetium-99m-DISIDA (99mTc-DISIDA) hepatobiliary scintigraphy. Ten men and three women with pulmonary tuberculosis were subjected to hepatobiliary scintigraphy at the beginning of triple treatment (M1) and two mon
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2006-04
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9. Alterações morfologicas e atividades e expressão de citocromos P450 no figado de ratos tratados com L-NAME / Hepatic morphological alterations and cytochrome P450 activities and expression in rats treated with L-NAME
Nitric oxide (NO), a co-product of the metabolism of L-arginine to L-citrulline by NO synthases (NOS), has an important role in regulating vascular tone, inflammatory responses, and the gene expression and enzymatic activity of various proteins, including cytochrome P450 and NOS. The chronic inhibition of NOS by Nffi-nitro-L-arginine methyl ester (L-NAME) pr
Publicado em: 2006
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10. Polymorphic inheritance of glutathione-S-transferase (GST) and the cytochrome P450 (CYP) genes, susceptibility to prostate cancer and prognostic / Analise do perfil genotipico do sistema glutationa S-transferase e citocromo P450 na avaliação de susceptibilidade ao cancer de prostata e de prognostico
Prostate cancer is currently the most common malignancy worldwide, second only to skin tumors. The incidence of prostate cancer has risen dramatically over the last decade, more than can be explained just by the increase in longevity. It is also apparent that prostate cancer is now being detected at less advanced stages than in the past. Increased awareness
Publicado em: 2006
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11. Lychnophora ericoides Mart: pharmacological evaluation and considerations on the oxidative metabolism from its bioactive compounds / Lychnophora ericoidesMart: avaliação farmacológica e considerações sobre o metabolismo oxidativo das substâncias bioativas
The scientific study of medicinal plants is a multidisciplinary task and involves many fields of knowledge such as physics, chemistry and biology. In this context, pharmacological and toxicological studies play an important role since they allow evaluating parameters such as safety and efficacy. These parameters have to be well established, being essential f
Publicado em: 2006
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12. Uma abordagem proteomica na identificação do citocromo P450 em Prochilodus Scrofa : uma nova ferramenta em ensaios ecotoxicologicos
Cytochromes P450 constitute a superfamily of the phase I enzymes whose primary task is the detoxification of both endogenous and xenobiotic compounds. This activity is only possible through the association of CYP with cytochrome b5 and the enzyme NADPH cytochrome P450 reductase. This association is possible because of membrane environment. Any alteration in
Publicado em: 2004