Cyclo Oxygenase 2
Mostrando 1-12 de 77 artigos, teses e dissertações.
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1. AVALIAÇÃO DOS FATORES DE CRESCIMENTO E COX-2 NA CICATRIZAÇÃO DE CAMUNDONGOS COM NEOPLASIA DE EHRLICH
RESUMO Racional: A cicatrização é fenômeno biológico inato, e a carcinogênese adquirido, mas com elementos humorais e celulares comuns. A carcinogênese interfere de forma negativa na cicatrização. Objetivo: Avaliar as modificações histológicas nas cicatrizes laparotômicas de camundongos Balb/c sadios como controles, e com a neoplasia de Ehrli
ABCD, arq. bras. cir. dig.. Publicado em: 2016-12
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2. Expression immunohistochemistry of the cyclo-oxygenase 2 (Cox2) and quantification of the nucleolus organizing region (NOR) in different histological patterns of a canine osteosarcoma / Expressão imunoistoquímica da cicloxigenase-2 (Cox2) e quantificação das regiões organizadoras de nucléolos (NORs) nos diferentes padrões histológicos do osteossarcoma canino
O propósito deste trabalho foi avaliar a intensidade da cicloxigenase 2 (Cox2), as Regiões Organizadoras de Nucléolos Impregnadas pela Prata (AgNORs) e as figuras de mitose por campo nos diferentes tipos de osteossarcomas canino, a partir de um estudo retrospectivo de pouco mais de 10 anos dos casos de osteossarcoma canino que surgiram na rotina da clíni
Publicado em: 2006
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3. Study of the Antinociceptive activity of Thalidomide, Pentoxifillyne and Chlorpromazine in Experimental Models / Avaliação da atividade antinociceptiva da talidomida, pentoxifilina e clorpromazina em modelos experimentais.
The release of cyclo-oxygenase products and sympathomimetic amines, the final mediators of inflammatory pain, is preceded by the generation of pro-inflammatory and nociceptive cytokines by resident cells. Recently drugs such as thalidomide (TALD), pentoxifylline (PTX) and chlorpromazine (CLP), despite of other effects, have been associated with immunomodulat
Publicado em: 2003
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4. Caracterização farmacologica do relaxamento da musculatura lisa do corpo cavernoso humano isolado induzido por cininas
Objective: To caracterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK). Lysbradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin (des-Arg9-BK), and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, nonch
Publicado em: 2002
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5. Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells
Calcium oxalate (CaOx) crystals adhere to and are internalized by tubular renal cells and it seems that this interaction is related (positively or negatively) to the appearance of urinary calculi. The present study analyzes a series of mechanisms possibly involved in CaOx uptake by Madin-Darby canine kidney (MDCK) cells. CaOx crystals were added to MDCK cell
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-01
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6. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials
Objective To estimate the analgesic efficacy of non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclo-oxygenase-2 inhibitors (coxibs), in patients with osteoarthritis of the knee.
BMJ Publishing Group Ltd..
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7. Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
Aims To determine the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 and other non-steroidal anti-inflammatory drugs (NSAIDs) in primary care between 2000 and 2004; to determine these risks in patients with and without pre-existing coronary heart disease and in those taking and not taking aspirin.
BMJ Publishing Group Ltd..
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8. Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture
Specimens of human rheumatoid and nonrheumatoid synovial lining were maintained in nonproliferative organ culture for 20 hours. The culture fluids were then assayed for prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and 6-keto-prostaglandin F1α (6-keto-PGF1α) by specific radioimmunoassay. The presence of each of these substances was confirmed by gas chrom
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9. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition of COX-1. Here we report data from two related assay systems, the human whole blood assay and a modified human whole blood assay (using human A549 cells as a source
The National Academy of Sciences.
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10. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches
Cold Spring Harbor Laboratory Press.
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11. Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.
When thrombin is added to washed human platelets, one of its actions results in activation of a phospholipase that hydrolyzes arachidonic acid from phospholipids. The arachidonate is converted to the cyclic endoperoxides (prostaglandin G2 and prostaglandin H2) by fatty acid cyclo-oxygenase. These compounds are then converted to thromboxane A2, also called ra
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12. Expression of a cyclo‐oxygenase‐2 transgene in murine liver causes hepatitis
BMJ Group.