Cyclamate
Mostrando 13-23 de 23 artigos, teses e dissertações.
-
13. Efeito do ciclamato de sódio sobre o pâncreas exócrino fetal de ratos: estudo cariométrico e esterelógico.
Cyclamate, a sweetening substance derived from N-cyclo-hexyl-sulfamic acid, is largely used as a non-caloric artificial edulcorant in foods and beverages as well as in the pharmaceutical industry. This study aims at evaluating different karyometric and stereological quantitative parameters in the exocrine pancreas of rat fetuses . In five pregnant rats, a do
Publicado em: 2006
-
14. Efeitos do ciclamato de sódio na placenta de ratas: estudo morfométrico.
Objetivo: Avaliar os efeitos do ciclamato de sódio na placenta de ratas com sua administração no período da embriogênese. Método: Foi administrado por via intraperitoneal nas ratas do grupo tratado a dose de 60 mg / Kg de ciclamato de sódio, do décimo ao décimo quarto dia de gestação, e volume equivalente de solução salina no grupo controle, pel
Publicado em: 2006
-
15. Efeitos do ciclamato de sódio sobre o testículo fetal de ratos: estudo morfométrico.
Objetivo: Avaliar os efeitos do ciclamato de sódio sobre o crescimento fetal e nas células testiculares de fetos de ratas tratadas durante a embriogênese. Método: Do décimo ao décimo terceiro dia de prenhez, foi administrado por via intraperitoneal, 50 mg/Kg de ciclamato de sódio nas ratas participantes do grupo tratado e, pela mesma via, igual volume
Publicado em: 2006
-
16. Carcinogen-Induced Chromosomal Breakage Decreased by Antioxidants
Blood leukocyte cultures were incubated with antioxidants and the carcinogens sodium cyclamate and 7,12-dimethylbenz(α)anthracene in different combinations. There were 17.4% more chromosomal breaks in the group of cells treated with dimethylbenzanthracene only than in the untreated controls. The reductions in chromosomal breaks by the antioxidants were as f
-
17. Saccharin and cyclamate inhibit binding of epidermal growth factor.
The binding of 125I-labeled mouse epidermal growth factor (EGF) to 18 cell lines, including HeLa (human carcinoma), MDCK (dog kidney cells), HTC (rat hepatoma), K22 (rat liver), HF (human foreskin), GM17 (human skin fibroblasts), XP (human xeroderma pigmentosum fibroblasts), and 3T3-L1 (mouse fibroblasts), was inhibited by saccharin and cyclamate. The human
-
18. Different functional roles of T1R subunits in the heteromeric taste receptors
The T1R receptors, a family of taste-specific class C G proteincoupled receptors, mediate mammalian sweet and umami tastes. The structure–function relationships of T1R receptors remain largely unknown. In this study, we demonstrate the different functional roles of T1R extracellular and transmembrane domains in ligand recognition and G protein coupling. Si
National Academy of Sciences.
-
19. Chemical induction of sperm abnormalities in mice.
The sperm of (C57BL X C3H)F1 mice were examined 1, 4, and 10 weeks after a subacute treatment with one of 25 chemicals at two or more dose levels. The fraction of sperm that were abnormal in shape was elevated above control values of 1.2-3.4% for methyl methanesulfonate, ethyl methanesulfonate, griseofulvin, benzo[a]pyrene, METEPA [tris(2-methyl-l-aziridinyl
-
20. The chloride current induced by expression of the protein pICln in Xenopus oocytes differs from the endogenous volume-sensitive chloride current.
1. Phenotypical similarities between ICl,swell, the cell-swelling-induced chloride current and ICln, the nucleotide-sensitive chloride current induced by expression of mammalian pICln in Xenopus oocytes, have led to models which identify pICln either as the volume-sensitive chloride channel or as a cytosolic regulator thereof. 2. To investigate critically th
-
21. Mechanism of NaCl and water reabsorption in the proximal convoluted tubule of rat kidney.
The role of chloride concentration gradients in proximal NaCl and water reabsorption was examined in superficial proximal tubules of the rat by using perfusion and collection techniques. Reabsorptive rates (Jv), chloride concentrations, and transtubular potential difference were measured during perfusion with solutions (A) simulating an ultrafiltrate of plas
-
22. Characteristics of Volume Reabsorption in Rabbit Superficial and Juxtamedullary Proximal Convoluted Tubules
Segments of superficial and juxtamedullary proximal convoluted tubules of the rabbit were perfused in vitro to examine the mechanisms responsible for net volume reabsorption. The very early postglomerular segments were not studied. Fluid reabsorptive rates and transepithelial potential differences were compared under various conditions: (a) with perfusate th
-
23. Characteristics of salt and water transport in superficial and juxtamedullary straight segments of proximal tubules.
The purpose of the present studies was to characterize the nature of salt and water transport out of the superficial (SF) and juxtamedullary (JM) straight segments of rabbit proximal tubules as examined by in vitro microperfusion techniques. When the perfusate consisted of a solution simulating ultrafiltrate of plasma, there were no differences between SF an