Crospovidone
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion
ABSTRACT Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then oral
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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2. Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate
A exigência por comprimidos de dissolução rápida aumentou durante a última década, especialmente para idosos e crianças, com dificuldades de deglutição . No presente trabalho prepararam-se, pelo método de compressão direta, comprimidos de tartarato de metoprolol de rápida dissolução, utilizando glicolato sódico de amido, croscarmellose sódica
Braz. J. Pharm. Sci.. Publicado em: 2013-12
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3. Study of pre-formulation, pharmaceutical development and characterization of solid dosage forms of olanzapine / Estudo de pré-formulação, desenvolvimento farmacotécnico e caracterização de formas farmacêuticas sólidas da olanzapina
Among manufacturing processes available, direct compression is indicated for OLZ because this drug is moisture sensitive. Before drug developement, preformulation investigations involving physical and chemical properties of drug and excipient combined and separated must be performed. Thus, drug solubility profile, thermal analysis techniques, mainly DSC and
Publicado em: 2010
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4. Avaliação das propriedades de fluxo dos granulados e dissolução de comprimidos de hidroclorotiazida 50 mg obtidos por granulação úmida
O processo de granulação úmida ainda encontra larga aplicabilidade junto à moderna indústria farmacêutica para a produção de comprimidos, pois elimina alguns dos principais problemas atribuídos à compressão direta: a tendência de segregação e as baixas propriedades de fluxo dos pós durante o processo. O presente trabalho avalia e compara atrav
Revista Brasileira de Ciências Farmacêuticas. Publicado em: 2007-09
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5. Preparation and assessment of novel coprocessed superdisintegrant consisting of crospovidone and sodium starch glycolate: A technical note
Coprocessed superdisintegrant consisting of crospovidone and SSG exhibited good flow and compression characteristics. Cefixime trihydrate and ibuprofen tablets containing coprocessed superdisintegrant exhibited quick disintegration and improved drug dissolution.
Springer-Verlag.
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6. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique
The purpose of this research was to develop mouth dissolve tablets of nimesulide. Granules containing nimesulide, camphor, crospovidone, and lactose were prepared by wet granulation technique. Camphor was sublimed from the dried granules by exposure to vacuum. The porous granules were then compressed. Alternatively, tablets were first prepared percentage fri
Springer-Verlag.
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7. Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets
Drugs that have narrow absorption window in the gastrointestinal tract (GIT) will have poor absorption. For these drugs, gastroretentive drug delivery systems offer the advantage in prolonging the gastric emptying time. Swellable, floating, and sustained release tablets are developed by using a combination of hydrophilic polymer (hydroxypropyl methylcellulos
Springer US.
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8. The influence of swelling capacity of superdisintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablets
The purpose of this study was to investigate the efficiency of superdisintegrants in promoting tablet disintegration and drug dissolution under varied media pH. Significant reductions in the rate and extent of water uptake and swelling were observed for both sodium starch glycolate (Primojel) and croscarmellose sodium (Ac-Di-Sol) in an acidic medium (0.1 N H
Springer-Verlag.
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9. Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion
The purpose of the present investigation was to increase the solubility and dissolution rate of rofecoxib by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 (PVP K30) using solvent evaporation method. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC), x-ray diffraction (XRD), and Fourier transfor
Springer-Verlag.
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10. Formulation Design and Optimization of Novel Taste Masked Mouth-Dissolving Tablets of Tramadol Having Adequate Mechanical Strength
The purpose of this work was to develop novel taste masked mouth-dissolving tablets of tramadol that overcomes principle drawback of such formulation which is inadequate mechanical strength. Tramadol is an opioid analgesic used for the treatment of moderate to severe pain. Mouth-dissolving tablets offer substantial advantages like rapid onset of action, bene
Springer US.