Cp 101 606
Mostrando 1-2 de 2 artigos, teses e dissertações.
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1. TRAXOPRODIL ATENUA AS CONVULSÕES INDUZIDAS POR PENTILENOTETRAZOL / TRAXOPRODIL ATTENUATES PENTYLENETETRAZOL-INDUCED SEIZURES
Há evidências de que as poliaminas facilitam convulsões por modular positivamente os receptores N-metil-D-aspartato (NMDAr), e que os antagonistas seletivos a subunidade NR2B do NMDAr têm atividade anticonvulsivante. Entretanto, permanece indeterminado se o traxoprodil (CP-101,606), um análogo do ifenprodil que age como antagonista seletivo na subunidad
Publicado em: 2010
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2. Functional consequences of NR2 subunit composition in single recombinant N-methyl-d-aspartate receptors
Single-channel recordings were obtained from Chinese hamster ovary cells transfected with the N-methyl-d-aspartate (NMDA) receptor subunit NR1 in combination with NR2A, NR2B, NR2C, or NR2A/NR2B. NMDA-activated currents were recorded under control conditions and in the presence of a thiol reductant (DTT), an oxidant (5,5′-dithio-bis[2-nitrobenzoic acid], DT
The National Academy of Sciences of the USA.