Corpus Cavernous
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Proerectile effect of an alkaloidical rich fraction isolated from aspidosperma ulei markgr.: in vivo and in vitro study. / Efeito pró-erétil de uma fração rica em alcalóides isolada de aspidosperma ulei markgr.: estudo in vivo e in vitro
The genus Aspidosperma (Apocyanaceae) is known to be rich in yohimbine type of indol alkaloids. This study was aimed to evaluate the alkaloid rich fraction (SF3-5) obtained from Aspidiosperma ulei Markgr. root bark for its general toxicity, behavioral effects in mice and a possible proerectile activity. Acute toxicity tests were performed to determine the LD
Publicado em: 2005
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14. Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
The molecular mechanism for priapism is not well characterized. Although the nitric oxide (NO) pathway is known to mediate penile erection under normal conditions, we hypothesized that the mechanism of priapism rests in aberrant downstream signaling of this pathway based on our previous findings that mice lacking the gene for endothelial nitric oxide synthas
National Academy of Sciences.
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15. A role for the melanocortin 4 receptor in sexual function
By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: (i) a highly selective non-peptide MC4R agonist aug
National Academy of Sciences.