Controlled Drug Delivery
Mostrando 1-12 de 97 artigos, teses e dissertações.
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1. Mass Variation Rate, in Acidic Environment, of Polyhydroxybutyrate and Chitosan matrices with Potential Application as Controlled Drug Delivery System
Polymers such as the biocompatible polyhydroxybutyrate (PHB) and the polysaccharide chitosan (Chi), a pH-sensitive polymer, have been studied for drug delivery applications and scaffolds production. In this work, matrices of PHB and Chi were produced by compression molding (SPHB-Chi) and loaded with a broad-spectrum biocide chlorhexidine (CHX) (SPHB-Chi-CHX)
Mat. Res.. Publicado em: 30/09/2019
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2. Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times fol
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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3. Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio
RESUMO As biocerâmicas bifásicas hidroxiapatita/fosfato tricálcico-beta (HA/TCP-β) microporosas são pesquisadas e se destacam em aplicações biomédicas como substitutos dos tecidos ósseos. Estes biomateriais são biocompatíveis e apresentam microestruturas microporosas interconectadas, que permitem sua utilização no reparo do tecido ósseo. Devido
Matéria (Rio J.). Publicado em: 16/09/2019
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4. Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
Resumo O MCM-41 é uma das cerâmicas mesoporosas mais estudadas para sistemas de liberação controlada de fármacos. Sua elevada área superficial específica e mesoporosidade permitem alta capacidade de adsorção. Apesar dos inúmeros trabalhos publicados na área biomédica, até o presente momento não há relatos de aplicações comerciais do MCM-41.
Cerâmica. Publicado em: 06/06/2019
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5. Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio
RESUMO As biocerâmicas bifásicas hidroxiapatita/fosfato tricálcico-beta (HA/TCP-β) microporosas são pesquisadas e se destacam em aplicações biomédicas como substitutos dos tecidos ósseos. Estes biomateriais são biocompatíveis e apresentam microestruturas microporosas interconectadas, que permitem sua utilização no reparo do tecido ósseo. Devido
Matéria (Rio J.). Publicado em: 20/05/2019
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6. Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases
Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of c
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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7. Adenanthera pavonina GALACTOMANNAN FOR CONTROLLED DELIVERY OF RUTIN - A PRELIMINARY STUDY
Improving the development of modified release matrix systems strictly depends on selecting an appropriate agent capable of controlling the drug's release. In this study, Adenanthera pavonina galactomannan was investigated as a potential basis for developing a controlled release of rutin. This galactomannan was extracted, purified and characterized by GPC, NM
Quím. Nova. Publicado em: 2018-06
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8. Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles
The aim of this study was to develop and characterize poly-ε-caprolactone (PCL) and poly(D,L-lactic-co-glycolic)-acid (PLGA) microparticles containing coencapsulated trans-dehydrocrotonin (t-DCTN) and t-DCTN:hydroxypropyl-β-cyclodextrin inclusion complex (t-DCTN:HP-β-CD), with t-DCTN loaded at concentrations ranging from 11.25 to 45.00 mg. A preformulatio
J. Braz. Chem. Soc.. Publicado em: 2017-08
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9. Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications
This work describes the development and characterization of triglyceride-based magnetic nanocomposites for application in magnetic hyperthermia and controlled drug delivery. The magnetic solid lipid nanocomposites (MSLN) constituted by mixtures of trilaurin-tricaprylin and trilaurin-tricaprin have been successfully obtained by emulsification-solvent evaporat
J. Braz. Chem. Soc.. Publicado em: 2017-08
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10. Liposomes as potential carriers for ketorolac ophthalmic delivery: formulation and stability issues
ABSTRACT Drug delivery to treat ocular disorders locally is a challenging endeavor. Traditional ocular dosage form - eye drops - exhibits poor availability, consequently inefficient therapeutic response. The objective of the study was to formulate and characterize a ketorolac tromethamine ocular system with a prolonged release pattern based on liposomes as a
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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11. Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying
Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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12. A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability
ABSTRACT Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to th
Braz. J. Pharm. Sci.. Publicado em: 2016-12