Conserved Charges
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. The novel p.E89K mutation in the SRY gene inhibits DNA binding and causes the 46,XY disorder of sex development
Male sex determination in humans is controlled by the SRY gene, which encodes a transcriptional regulator containing a conserved high mobility group box domain (HMG-box) required for DNA binding. Mutations in the SRY HMG-box affect protein function, causing sex reversal phenotypes. In the present study, we describe a 19-year-old female presenting 46,XY karyo
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04
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2. Sólitons e teorias não lineares integráveis / Solitons and Nonlinear Integrable Systems
Uma generalização dos modelos de Toda bidimensionais pela inclusão de campos de Dirac é estudada através de métodos algébricos que possibilitam a construção de cargas e soluções para o modelo. Após desenvolver o formalismo matemático necessário, as cargas conservadas do modelo em questão são determinadas para soluções sóliton, a partir da
Publicado em: 2009
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3. Integrable field theories and solitons / Teorias de campos integráveis e sólitons
Os modelos de Toda admitem uma representação de suas equações de movimento em termos da curvatura nula, isto é, existem potenciais que são funcionais dos campos da teoria e pertencem a uma álgebra de Kac-Moody tal que a condição de curvatura nula seja equivalente às equações de movimento. Para a construção das soluções solitônicas e cargas c
Publicado em: 2009
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4. "Planejamento de quinonas com atividade tripanossomicida" / Planning of quinone compounds with trypanocidal activity
A set of 25 quinone compounds with anti-trypanocidal activity was studied by using the Density Functional Theory (DFT) method in order to calculate electronic atomic and molecular properties to be correlated with the biological activity. The chemometric methods Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), Stepwise Discriminant Ana
Publicado em: 2007
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5. Conserved gravitational charges, locality and the holographic weyl anomaly: a fresh viewpoint
Since the proposal of the AdS/CFT correspondence, made by Maldacena and Witten, there has been some controversy about the definition of conserved Noether charges associated with asymptotic isometries in asymptotically AdS spacetimes, namely, whether they form an anomalous (i.e., a nontrivial central extension) representation of the Lie algebra of the conform
Brazilian Journal of Physics. Publicado em: 2005-12
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6. The effects of conserved charges in a nuclear equation of state
We report the present status on the construction of an equation of state (EoS) for the strongly interacting matter which is to be used in the hydrodynamical calculations for the ultra-relativistic heavy ion collisions. In the present version, the conservation of isospin, baryon number and strangeness are taken into account. A preliminary hydrodynamical resul
Brazilian Journal of Physics. Publicado em: 2004-03
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7. Assessment of the transcriptional activation potential of the HMG chromosomal proteins.
Chromosomal proteins HMG-14, HMG-17, and HMG-1 are among the most abundant, ubiquitous, and evolutionarily conserved nonhistone proteins. Analysis of their structure reveals features which are similar to those of certain transcription factors. The distribution of charged amino acid residues along the polypeptide chains is asymmetric: positive charges are clu
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8. High-Chloride Concentrations Abolish the Binding of Adenine Nucleotides in the Mitochondrial ADP/ATP Carrier Family
The ADP/ATP carrier (AAC) is a very effective membrane protein that mediates the exchange of ADP and ATP across the mitochondrial membrane. In vivo transport measurements on the AAC overexpressed in Escherichia coli demonstrate that this process can be severely inhibited by high-chloride concentrations. Molecular-dynamics simulations reveal a strong modific
The Biophysical Society.
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9. Amino acid–amino acid contacts at the cooperativity interface of the bacteriophage λ and P22 repressors
The bacteriophage λ repressor and its relatives bind cooperatively to adjacent as well as artificially separated operator sites. This cooperativity is mediated by a protein–protein interaction between the DNA-bound dimers. Here we use a genetic approach to identify two pairs of amino acids that interact at the dimer–dimer interface. One of these pairs i
Cold Spring Harbor Laboratory Press.
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10. Mutational analysis of the leucine zipper motif in the Newcastle disease virus fusion protein.
The paramyxovirus fusion proteins have a highly conserved leucine zipper motif immediately upstream from the transmembrane domain of the F1 subunit (R. Buckland and F. Wild, Nature [London] 338:547, 1989). To determine the role of the conserved leucines in the oligomeric structure and biological activity of the Newcastle disease virus (NDV) fusion protein, t
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11. Characterization of a chloroplast inner envelope K+ channel.
A K(+)-conducting protein of the chloroplast inner envelope was characterized as a K+ channel. Studies of this transport protein in the native membrane documented its sensitivity to K+ channel blockers. Further studies of native membranes demonstrated a sensitivity of K+ conductance to divalent cations such as Mg2+, which modulate ion conduction through inte
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12. Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab
OspA (outer surface protein A) is an abundant immunogenic lipoprotein of the Lyme disease spirochete Borrelia burgdorferi. The crystal structure of a soluble recombinant form of OspA was solved in a complex with the Fab fragment of mouse monoclonal antibody 184.1 and refined to a resolution of 1.9 Å. OspA has a repetitive antiparallel β topology with an u
The National Academy of Sciences of the USA.