Congenic Mice
Mostrando 1-12 de 292 artigos, teses e dissertações.
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1. Experimentos de microarrays e teoria da resposta ao item / Microarryas experiments and Iten Response Theory
Recentemente desenvolvida, a biotecnologia denominada por Microarrays permite o monitoramento simultâneo dos valores de expressão gênica de centenas de milhares de genes, fator este que traz uma nova interpretação aos resultados obtidos em pesquisas desenvolvidas nas mais diversas áreas do conhecimento incluindo, por exemplo, a Farmacologia e Medicina,
Publicado em: 2010
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2. Efeito da terapia com Beta-bloqueadores em camundongos com deleção dos receptores alpha 2A/alpha 2C adrenérgicos / Effects of b- adrenergic antagonist therapy in mice lacking a 2A/a 2C adrenergic receptors
We have recently reported that disruption for both a2A ?and a2C adrenergic receptor subtypes in mice (KO) leads to sympathetic hyperactivity with evidence of heart failure (HF) by the age of 7 months. These mice provide a model system for evaluating the efficiency among different ?- adrenergic antagonists (BB) for HF therapy. In the present study, we evaluat
Publicado em: 2006
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3. Efeito do treinamento físico na cardiomiopatia induzida por hiperatividade simpática em camundongos com ablação dos receptores alpha 2A/alpha 2C- adrenérgicos / Effect of exercise training on cardiomyopathy induced by sympathetic hiperactivity in mice lacking a2A/a2C- adrenoceptors
Presynaptic a2-adrenoceptors (a2 AR) regulate the cardiovascular function by inhibiting neurotransmitter release on the sympathetic nerve terminals. We have recently reported that disruption for both a2A and a2C AR subtypes in mice (KO) leads to sympathetic hyperactivity with evidence of cardiac dysfunction by 4 mo of age. These mice provide a model system f
Publicado em: 2006
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4. Odor types determined by the major histocompatibility complex in germfree mice.
The major histocompatibility complex (MHC) is the prime but not exclusive determinant of genetically specific constitutive body odors, termed odor types, represented strongly in urine of the mouse. Perception of MHC-determined odor types influences reproductive behavior in the contexts of mate choice and maintenance of early pregnancy, tending to favor the p
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5. Leukemogenesis, immune responsiveness, and murine leukemia virus expression in congenic AKR/J mice differing at H-2.
In this study we examined the leukemia incidence, ectropic and xenotropic murine leukemia virus expression, and immune responsiveness of congenic AKR/J mice differing at the H locus. Congenic AKR.L-H-2b/1 mice, bearing the H-2b haplotype derived from C57L/J, were found to have a significant delay in time of death due to leukemia relative to that of AKR/J (H-
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6. Tissue-specific expression of the newly acquired ecotropic Emv-18 provirus in Fv-2 congenic mice.
Expression of endogenous retroviral sequences in Fv-2 congenic mouse strains was examined by Northern blot analysis. Endogenous ecotropic virus transcripts were observed in total spleen RNA of B6.S (Fv-2ss) mice. Endogenous ecotropic transcripts were not detected in spleen RNA of C57BL/6, the Fv-2rr congenic partner of B6.S, nor in spleens of the C57BL/10 (F
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7. Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals?
BioMed Central.
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8. A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites.
BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimu
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9. Inheritance of Susceptibility to Friend Mouse Leukemia Virus: VI. Reciprocal Alteration of Innate Resistance or Susceptibility by Bone Marrow Transplantation Between Congenic Strains
Two newly established mouse strains which are congenic with standard inbred strains were used for the study of the locus Fv which controls the susceptibility to Friend leukemia virus in mice. A strain in each congenic pair shares the major histocompatibility gene with the corresponding partner strain but differs from the latter in the Fv locus. Mice with Fvr
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10. Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To investigate prion diversity, we inoculated three "strains" of prions into congenic and transgenic mice harboring variable numbers of two different alleles, designated a and b, of the prion protein (PrP) s
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11. Mice That Are Congenic for the char2 Locus Are Susceptible to Malaria
A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.
American Society for Microbiology.
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12. Suppression of IgE secretion from hybridoma cells in allotype congenic mice: suppression of allotype 7a by T cells in allotype b mice.
Anti-2,4-dinitrophenyl (DNP) IgE producing hybridoma B 53 when injected subcutaneously is established equally well in syngeneic BALB/c (heavy-chain allotype a) and congenic CB20 (heavy-chain allotype b) mice. However, secretion of anti-DNP IgE monoclonal antibody is greatly suppressed in CB20 mice. B 53 cells taken from the subcutaneous tumors of CB20 mice p