Component Loader
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Component loading with utilization of a components ontology / Ativação de componentes de software com a utilização de uma ontologia de componentes
Atualmente, existem muitos estudos para agregar mais valor às informações disponíveis na Web visando melhorar os resultados da interação dos usuários com a Web; uma das linhas de estudo é a Web Semântica, que propõe a adição de informação semântica à Web atual por meio de ontologias. A organização internacional que define os padrões para a
Publicado em: 2007
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2. Genomic instability and endoreduplication triggered by RAD17 deletion
Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage and replication stress. To explore the role of Rad17 in the maintenance of genomic integrity, we established somatic conditional alleles of RAD17 in human cells. We find that RAD17 is
Cold Spring Harbor Laboratory Press.
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3. Impairment of lagging strand synthesis triggers the formation of a RuvABC substrate at replication forks
The holD gene codes for the ψ subunit of the Escherichia coli DNA polymerase III holoenzyme, a component of the γ complex clamp loader. A holD mutant was isolated for the first time in a screen for mutations that increase the frequency of tandem repeat deletions. In contrast to tandem repeat deletions in wild-type strains, deletion events stimulated by the
Oxford University Press.
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4. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination
Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC genes in higher eukaryotes remains elusive. Here, we report
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5. Functional Interactions of a Homolog of Proliferating Cell Nuclear Antigen with DNA Polymerases in Archaea
Proliferating cell nuclear antigen (PCNA) is an essential component of the DNA replication and repair machinery in the domain Eucarya. We cloned the gene encoding a PCNA homolog (PfuPCNA) from an euryarchaeote, Pyrococcus furiosus, expressed it in Escherichia coli, and characterized the biochemical properties of the gene product. The protein PfuPCNA stimulat
American Society for Microbiology.