Combinatorial Molecular Modeling
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Modelagem combinatÃria de compostos com valores elevados de seÃÃo de choque para absorÃÃo de dois fÃtons
A absorÃÃo de dois fÃtons por molÃculas orgÃnicas possui muitas aplicaÃÃes tecnolÃgicas importantes, fazendo a modelagem teÃrica e a sÃntese de novas molÃculas com valores elevados de seÃÃo de choque para absorÃÃo de dois fÃtons, δ (ω ) , atividades muito necessÃrias. A absorÃÃo de dois fÃtons à um processo Ãptico nÃo-linear
Publicado em: 2008
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2. Secondary Structure and Hybridization Accessibility of Hepatitis C Virus 3′-Terminal Sequences
The 3′-terminal sequences of hepatitis C virus (HCV) positive- and negative-strand RNAs contribute cis-acting functions essential for viral replication. The secondary structure and protein-binding properties of these highly conserved regions are of interest not only for the further elucidation of HCV molecular biology, but also for the design of antisense
American Society for Microbiology.
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3. Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-l-tyrosine
Although incorporation of amino acid analogs provides a powerful means of producing new protein structures with interesting functions, many amino acid analogs cannot be incorporated easily by using the wild-type aminoacyl-tRNA synthetase (aaRS). To be able to incorporate specific amino acid analogs site-specifically, it is useful to build a mutant aaRS that
The National Academy of Sciences.
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4. Importance of the reverse Hoogsteen base pair 54-58 for tRNA function
To elucidate the general constraints imposed on the structure of the D- and T-loops in functional tRNAs, active suppressor tRNAs were selected in vivo from a combinatorial tRNA gene library in which several nucleotide positions of these loops were randomized. Analysis of the nucleotide sequences of the selected clones demonstrates that among the randomized n
Oxford University Press.
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5. Generation of native bovine mAbs by phage display
Modeling of disease pathogenesis and immunity often is carried out in large animals that are natural targets for pathogens of human or economic relevance. Although murine mAbs are a valuable tool in identifying certain host/pathogen interactions, progress in comparative immunology would be enhanced by the use of mAbs isolated from the host species. Such anti
The National Academy of Sciences.
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6. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.
We examined the positive and negative effects of somatic mutation on antibody function using saturation mutagenesis in vitro to mimic the potential of the in vivo process to diversify antibodies. Identical mutations were introduced into the second complementarity determining region of two anti-phosphocholine antibodies, T15 and D16, which share the same germ