Combinatorial Library
Mostrando 1-12 de 163 artigos, teses e dissertações.
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1. QUANTUM INSPIRED PARTICLE SWARM COMBINED WITH LIN-KERNIGHAN-HELSGAUN METHOD TO THE TRAVELING SALESMAN PROBLEM
ABSTRACT The Traveling Salesman Problem (TSP) is one of the most well-known and studied problems of Operations Research field, more specifically, in the Combinatorial Optimization field. As the TSP is a NP (Non-Deterministic Polynomial time)-hard problem, there are several heuristic methods which have been proposed for the past decades in the attempt to solv
Pesqui. Oper.. Publicado em: 2015-12
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2. Produção e caracterização da porção Fab do anticorpo anti-digoxina utilizando a tecnologia de phage display. / Production and characterization of the Fab portion of anti-digoxin antibody by phage display technology.
Digoxin is a pharmaceutical used in the control of cardiac dysfunction. Its therapeutic window is very narrow. To counteract the toxic effect, polyclonal anti-digoxin Fab fragments are commercially available. Our goal was to obtain variants of monoclonal anti-digoxin Fab fragments by phage display technology, which allows the generation of high affinity and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/03/2012
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3. Triagem, aplicação e engenharia de biocatalisadores para transformações enantio e regiosseletivas / Screening, applying and engineering biocatalysts for enantio and regioselective transformations
Biocatalysts have been widely applied in recent decades for industrial processes yielding high value products under environmentally friendly reaction conditions. The development of biocatalysts often begins with screening to identify enzymes with suitable activities followed by characterization of the enzymes chemo-, regio- and stereoselectivity or stability
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/06/2011
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4. Caracterização de proteinases envolvidas na geração de peptídeos antimicrobianos no intestino de Rhipicephalus (Boophilus) microplus. / CE. Characterization of proteinases involved in the generation of antimicrobial peptides in the gut of Rhipicephalus (Boophilus) microplus.
It is known that hemoglobin is a rich source of antimicrobial peptides (hemocidins). The first hemoglobin-derived hemocidin characterized in ticks was the peptide Hb33-61, which is active against Gram-positive bacteria and fungi. It is believed that hemocidins are endogenously generated in the tick gut. In this work we biochemically characterized a cathepsin
Publicado em: 2010
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5. Escalonamento de projetos com restrições de recursos e múltiplos modos de processamento : soluções heurísticas e uma aplicação à programação de manutenção industrial
Esse trabalho apresenta uma implementação da meta-heurística GRASP para a resolução do Problema de Escalonamento de Projetos com Restrições de Recursos e Múltiplos Modos de Processamento (MRCPSP). O MRCPSP é um problema da classe NP Difícil e por isso vem recebendo atenção dos pesquisadores. Nessa dissertação, também é apresentado um estudo d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/06/2009
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6. Construção de uma biblioteca de anticorpos recombinantes (FAB) anti-carcinoma mamário e obtenção de fragmentos ligantes de antígenos tumorais por phage display
Breast carcinoma (BC) is currently regarded as a complex and heterogeneous disease presenting abnormalities in several molecular pathways. Although BC is the leading female cancer in incidence and the second one in mortality worldwide, the prognostic and predictive factors known are incapable to predict the outcome of all patients as well as to avoid unneces
Publicado em: 2009
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7. Variantes de inibidores de [alfa]-amilases selecionados por Phage Display com atividade para [alfa]-amilases do bicudo do algodoeiro (Anthonomus grandis, coleptera: curculionidae)
The cotton boll weevil Anthonomus grandis is an important insect-pest, that causes severe damage in cotton floral fruits and buds. The A. gradis larvae development control is a difficult job because it occurs inside the cotton floral structures. Starch granules from cotton structure are digested by a-amylases secreted to the intestinal lumen. However, a-amyl
Publicado em: 2007
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8. ConstruÃÃo de uma biblioteca de anticorpos (scFv) apresentada em fagos para seleÃÃo, anÃlise e caracterizaÃÃo de antÃgenos do carrapato bovino (Boophilus microplus)
CAPÃTULO I: The amplification of fragmentos scFv (single chain fragments variable) of immunized animals is an important method to generation of monoclonal antibodies. In this work chickens had been immunized with proteins of the larval and adult phases of the Boophilus microplus for the generation of an antibodies combinatorial library. Total RNA of spleen
Publicado em: 2007
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9. Construção de uma biblioteca de anticorpos (scFv) apresentada em fagos para seleção, análise e caracterização de antígenos do carrapato bovino (Boophilus microplus)
CAPÍTULO I: A amplificação de fragmentos scFv (fragmentos variáveis de cadeia única) de animais imunizados é um importante método na geração de anticorpos monoclonais. Neste trabalho galinhas foram imunizadas com proteínas totais das fases larval e adulta (teleóginas) do carrapato bovino Boophilus microplus para a geração de uma biblioteca combi
Publicado em: 2007
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10. Síntese e avaliação biológica de uma coleção de amidas / Síntese e avaliação biológica de uma coleção de amidas
The present study describes the preparation of amides containing the methylenedioxyphenyl group and also their activity against the leaf-cutting ant, Atta sexdens rubropilosa, its symbiotic fungus Leucoagaricus gongylophorus and the fall armyworm, Spodoptera frugiperda, larvae. From the bioassays it was observed that N-piperidine-3-(3,4- methylenedioxyphenyl
Publicado em: 2006
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11. Metaheuristicas aplicadas ao planejamento da expansão da transmissão de energia eletrica em ambientes de processamento distribuido
In this work, several combinatorial metaheuristics are developed for solving the transmission expansion planning problem of electric power systems that is analysed considering the static and long-term approach, e.g. a parallel version of the simulated annealing methodology and several parallel versions of a genetic algorithms, besides an asynchronous team wh
Publicado em: 2004
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12. Design and applications of modified oligonucleotides
Oligonucleotides have a wide range of applications in fields such as biotechnology, molecular biology, diagnosis and therapy. However, the spectrum of uses can be broadened by introducing chemical modifications into their structures. The most prolific field in the search for new oligonucleotide analogs is the antisense strategy, where chemical modifications
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-02