Combination Of Antigens
Mostrando 1-12 de 325 artigos, teses e dissertações.
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1. Enhancing immune effects of a DNA vaccine against kidney cancer using CD40L as an adjuvant
The use of specific combinations of antigens and adjuvant represents a promising approach for increasing the immunogenicity of DNA vaccines. In the present study, we evaluated the immunity and antitumor effects of DNA vaccines with G250 as the target antigen in a mouse model of renal cell carcinoma. We constructed two recombinant plasmids, pVAX1-G250 and pVA
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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2. Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy
BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities. Antibodies against several Mycobacterium leprae antigens have, however, shown value as diagnostic and/or prognostic markers. OBJECTIVES The objective of this study was to evaluate serum immunoglobulin
Mem. Inst. Oswaldo Cruz. Publicado em: 26/02/2018
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3. Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some metho
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-08
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4. Análise da resposta imune induzida pela imunização experimental com antígenos recombinantes de Plasmodium vivax / Analysis of the immune response induced by experimental immunization with recombinant antigens of Plasmodium vivax
A malária é uma das prioridades da pesquisa mundial na área de desenvolvimento de vacinas. Apesar da contínua e crescente atividade de pesquisa nessa área, ainda não existe uma vacina capaz de impedir a infecção pelo Plasmodium spp. Devido ao complexo ciclo de vida deste agente, uma formulação vacinal eficaz para a indução de uma resposta imune p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2012
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5. Tetramethylpyrazine potentiates arsenic trioxide activity against HL-60 cell lines
The objective of this study was to evaluate the effects of tetramethylpyrazine (TMP) in combination with arsenic trioxide (As2O3) on the proliferation and differentiation of HL-60 cells. The HL-60 cells were treated with 300 µg/mL TMP, 0.5 µM As2O3, and 300 µg/mL TMP combined with 0.5 µM As2O3, respectively. The proliferative inhibition rates were determ
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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6. Synergism/complementarity of recombinant adenoviral vectors and other vaccination platforms during induction of protective immunity against malaria
The lack of immunogenicity of most malaria antigens and the complex immune responses required for achieving protective immunity against this infectious disease have traditionally hampered the development of an efficient human malaria vaccine. The current boom in development of recombinant viral vectors and their use in prime-boost protocols that result in en
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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7. Identification of candidate antigens from adult stages of Toxocara canis for the serodiagnosis of human toxocariasis
In the present work, we identified adult Toxocara canis antigens through sodium dodecyl sulfate-polyacrylamide gel electrophoresis for potential use in human toxocariasis immunodiagnosis. The sensitivity and specificity of several semi-purified antigens, as well as their cross-reactivity with other parasitic infections, were assessed by IgM and IgG-enzime li
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-03
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8. Seleção e caracterização de peptídeos miméticos a proteínas tumorais no estadiamento clínico-patológico do câncer de próstata
Prostate cancer is the second cause of deaths by tumor in men, surpassed only to lung cancer. Currently, PSA (prostate-specific antigen) is clinical test of choice for PCa detection and treatment. However, the limitations of the PSA test such as large number of false positive results and unnecessary biopsies indicate the need for other means of screening for
Publicado em: 2010
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9. AnÃlise da antigenicidade e expressÃo de quatro novas proteÃnas hipotÃticas de Leishmania.(Leishmania) Chagasi
Leishmaniasis are parasitary infectious-diseases endemic in many countries caused by protozoan parasites of the genus Leishmania. Current strategies to combat visceral leishmaniasis, the most lethal and often fatal form of the disease unless treated, have not so far been successful. For this reason identification of recombinant antigens that can be used in d
Publicado em: 2009
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10. Avaliação de dois clones de Escherichia coli recombinante quanto ao crescimento e expressão de antígenos de Leishmania chagasi (kmp11 e P36)
Visceral leishmaniosis caused by Leishmania chagasi, also known as calazar, presented, in the period from 1990 to 2005, tax of incidence in Brazil varying between 1 and 3 cases for 100 000 inhabitants. The Northeast region that up to the year of 2000 contributed with almost 90% of the registered cases is reducing his participation in the current decade, reac
Publicado em: 2009
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11. Comparison of serological responses in two different populations with pulmonary tuberculosis
Observational studies on the humoural immune responses of the Warao indigenous people from Delta Amacuro, an isolated area, were compared with urban residents of the Venezuelan capital. Mycobacterium tuberculosis-specific reactivities (IgM, IgE, sIgA, IgG and IgG subclasses) were measured by ELISA using PPD and 38-kDa M. tuberculosis antigens. A total of 294
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-11
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12. Serodiagnosis of tuberculosis: specific detection of free and complex-dissociated antibodies anti-mycobacterium tuberculosis recombinant antigens
The diagnostic test characteristics of detecting free and complex-dissociated IgG to three recombinant antigens of Mycobacterium tuberculosis (38-kDa, Ag16 and Ag85B), singly and in combination, were evaluated in sera from 161 tuberculous patients [smear-positive pulmonary TB (50), smear-negative pulmonary TB (pTBsm-) (60) and extrapulmonary TB (51)) and 214
Brazilian Journal of Infectious Diseases. Publicado em: 2008-06