Co Expression Analysis
Mostrando 1-12 de 533 artigos, teses e dissertações.
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1. Campsiandra laurifolia Reduces Oxidative Stress and Inflammation in Rats with Ulcerative Colitis
Abstract Ulcerative colitis (UC) affects the mucosa and submucosa of the large intestine. One of the mechanisms involved in its etiology is oxidative stress (OS), directly involved in the inflammatory process characteristic of UC. The Campsiandra laurifolia, known as acapurana, was described as possessing antioxidant properties. We used 24 male Wistar rats,
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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2. From Third World Theory to Belt and Road Initiative: International Aid as a Chinese Foreign Policy Tool
Resumo Em 1946, Mao Zedong começou a elaborar sua teoria do Terceiro Mundo a partir da percepção de que haveria uma ‘zona intermediária’ de países entre as duas superpotências. De lá, ele concluiu que a África, a América Latina e a Ásia, com exceção do Japão, comporiam as forças revolucionárias capazes de derrotar o imperialismo, o colonia
Contexto int.. Publicado em: 02/12/2019
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3. Screening potential prognostic biomarkers of long non-coding RNAs for predicting the risk of chronic kidney disease
Not much is known about the roles of long non-coding RNAs (lncRNAs) for chronic kidney disease (CKD). In this study, we included CKD patient cohorts and normal controls as a discovery cohort to identify putative lncRNA biomarkers associated with CKD. We first compared the lncRNA expression profiles of CKD patients with normal controls, and identified differe
Braz J Med Biol Res. Publicado em: 07/11/2019
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4. Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway
Abstract Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH) assay, cell counting kit-8 (CCK-8), Hoechst 33342/PI double staining and flow cytometry assay
Acta Cir. Bras.. Publicado em: 14/10/2019
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5. Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study
Abstract SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis. This study aims to determine association of SOX2 and podoplanin expression in the progression of oral squamous cell carcinomas and
J. Appl. Oral Sci.. Publicado em: 09/09/2019
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6. [PROVISIONAL] Overexpression of rice F-box protein OsFBX322 confers increased sensitivity to gamma irradiation in Arabidopsis
Abstract Ionizing radiation has a substantial effect on physiological and biochemical processes in plants via induction of transcriptional changes and diverse genetic alterations. Previous microarray analysis showed that rice OsFBX322, which encoded a rice F-box protein, was downregulated in response to three types of ionizing radiation: gamma irradiation, i
Genet. Mol. Biol.. Publicado em: 02/09/2019
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7. Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology
Abstract The aim of this study was to evaluate the impact and mechanism of co-blocking of costimulatory signals CD28-B7-CD40-CD40L during immune allograft rejection. Forty-eight recipient rabbits were prepared as a high-risk corneal allograft model. After surgery, the animals were randomly divided into: control group, MR1 group, anti-B7 group, and co-blockin
Genet. Mol. Biol.. Publicado em: 18/07/2019
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8. Expression analysis of long non-coding RNAs in a renal ischemia-reperfusion injury model
Abstract Purpose: To investigate the long non-coding RNAs (lncRNAs) profile on renal ischemia reperfusion in a mouse model. Methods: Microarray analysis was used to study the expression of misregulated lncRNA in a mouse model of renal ischemia reperfusion(I/R) with long ischemia time. Quantitative real-time PCR (qPCR) was used to verify the expression of
Acta Cir. Bras.. Publicado em: 29/04/2019
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9. Protein-protein interactions of the nicotinamide/nicotinate mononucleotide adenylyltransferase of Leishmania braziliensis
BACKGROUND Nicotinamide adenine dinucleotide (NAD) plays a central role in energy metabolism and integrates cellular metabolism with signalling and gene expression. NAD biosynthesis depends on the enzyme nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT; EC: 2.7.7.1/18), in which converge the de novo and salvage pathways. OBJECTIVE The pu
Mem. Inst. Oswaldo Cruz. Publicado em: 21/03/2019
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10. Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were recruited and their genotypes for ADAMTS5 gene rs226794 a
Braz J Med Biol Res. Publicado em: 10/01/2019
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11. Low-intensity pulsed ultrasound promotes proliferation and migration of HaCaT keratinocytes through the PI3K/AKT and JNK pathways
Although the effects of low-intensity pulsed ultrasound (LIPUS) on diverse cell types have been fully studied, the functional role of LIPUS in keratinocytes remains poorly understood. This study aimed to investigate the effects of LIPUS on proliferation and migration of HaCaT cells as well as the regulatory mechanisms associated with signaling pathways. Huma
Braz J Med Biol Res. Publicado em: 18/10/2018
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12. Glutathione depletion triggers actin cytoskeleton changes via actin-binding proteins
Abstract The importance of glutathione (GSH) in alternative cellular roles to the canonically proposed, were analyzed in a model unable to synthesize GSH. Gene expression analysis shows that the regulation of the actin cytoskeleton pathway is strongly impacted by the absence of GSH. To test this hypothesis, we evaluate the effect of GSH depletion via buthion
Genet. Mol. Biol.. Publicado em: 04/06/2018